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Cat. No.: HY-117086

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GSK065

GSK065 is a KMO inhibitor with an IC₅₀ of 2.5 nM and a K_i of 0.05 nM. GSK065 prevents the effective binding of NADPH to its substrate. GSK065 can be used in studies related to multiple organ dysfunction syndrome associated with acute pancreatitis.

For research use only. We do not sell to patients.

CAS No.: 1953156-61-0
Formula: C₁₇H₁₅ClN₂O₄
Molecular Weight:346.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSK065 Chemical Structure

CAS No.: 1953156-61-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

GSK065 does not stimulate human KMO to produce hydrogen peroxide; instead, it reduces peroxide levels below basal levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 1953156-61-0
Molecular Weight 346.77
Formula C₁₇H₁₅ClN₂O₄
SMILES

C(CC(O)=O)C=1C=2C(=CC(O[C@H](C)C3=CC=CC=N3)=C(Cl)C2)ON1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hutchinson JP, et al. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nature communications. 2017 Jun 12;8:15827. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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