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Cat. No.: HY-182692

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KMO-IN-1

KMO-IN-1 is a KMO inhibitor with a mean pIC₅₀ of 8.5 against KMO. KMO-IN-1 can be used in the research of acute pancreatitis.

For research use only. We do not sell to patients.

CAS No.: 1953156-92-7
Formula: C₁₈H₁₇ClN₂O₄
Molecular Weight:360.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KMO-IN-1 Chemical Structure

CAS No.: 1953156-92-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

KMO-IN-1 is a KMO inhibitor with a mean pIC₅₀ of 8.5 against KMO. KMO-IN-1 can be used in the research of acute pancreatitis^[1].

In Vitro

KMO-IN-1 (Compound 30) potently inhibits human KMO with a mean pIC₅₀ of 8.5^[1].
KMO-IN-1 potently inhibits KMO activity in HEK cells with a mean pIC₅₀ of 8.8^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	CL_blood	V_dss
Rat^[1]	1 mg/kg	i.v.	3.6 h	1.1 mL/min/kg	0.31 L/kg

Chemical Information

CAS No. 1953156-92-7
Molecular Weight 360.79
Formula C₁₈H₁₇ClN₂O₄
SMILES

OC(CCC(C1=C2)=NOC1=CC(O[C@@H](C3=CC=C(C=N3)C)C)=C2Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Walker AL, et al. Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. J Med Chem. 2017;60(8):3383-3404. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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