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Cat. No.: HY-182692

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KMO-IN-1

KMO-IN-1 is a KMO inhibitor with a mean pIC₅₀ of 8.5 against KMO. KMO-IN-1 can be used in the research of acute pancreatitis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1953156-92-7
Formule: C₁₈H₁₇ClN₂O₄
Masse moléculaire:360.79

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KMO-IN-1 Chemical Structure

CAS No.: 1953156-92-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

KMO-IN-1 is a KMO inhibitor with a mean pIC₅₀ of 8.5 against KMO. KMO-IN-1 can be used in the research of acute pancreatitis^[1].

In Vitro

KMO-IN-1 (Compound 30) potently inhibits human KMO with a mean pIC₅₀ of 8.5^[1].
KMO-IN-1 potently inhibits KMO activity in HEK cells with a mean pIC₅₀ of 8.8^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	CL_blood	V_dss
Rat^[1]	1 mg/kg	i.v.	3.6 h	1.1 mL/min/kg	0.31 L/kg

Chemical Information

CAS No. 1953156-92-7
Masse moléculaire 360.79
Formule C₁₈H₁₇ClN₂O₄
SMILES

OC(CCC(C1=C2)=NOC1=CC(O[C@@H](C3=CC=C(C=N3)C)C)=C2Cl)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Walker AL, et al. Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. J Med Chem. 2017;60(8):3383-3404. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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