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  4. Sulfadiazine 100 µg/mL in methanol

Sulfadiazine 100 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadiazine 100 µg/mL in methanol competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine 100 µg/mL in methanol persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine 100 µg/mL in methanol targets Toxoplasma gondii DHPS enzyme. Sulfadiazine 100 µg/mL in methanol can be used for the research of congenital toxoplasmosis and bacterial infection.

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Sulfadiazine 100 µg/mL in methanol

Sulfadiazine 100 µg/mL in methanol Chemical Structure

CAS No. : 68-35-9

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Based on 8 publication(s) in Google Scholar

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Sulfadiazine 100 µg/mL in methanol Related Antibodies

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Description

Sulfadiazine 100 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadiazine 100 µg/mL in methanol competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine 100 µg/mL in methanol persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine 100 µg/mL in methanol targets Toxoplasma gondii DHPS enzyme. Sulfadiazine 100 µg/mL in methanol can be used for the research of congenital toxoplasmosis and bacterial infection[1][2][3][4].

In Vitro

Sulfadiazine 100 µg/mL in methanol is associated with low sensitivity linked to the novel R265H and I347M mutations in the dhps gene of Toxoplasma gondii strains TgCTBr4 and TgCTBr17[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfadiazine 100 µg/mL in methanol Related Antibodies
In Vivo

Sulfadiazine (10-640 mg/kg/d; p.o.; daily for 10 days) 100 µg/mL in methanol reduced the number of brain cysts in mice infected with T. gondii (TgCTBr) except for TgCTBr4[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss Webster (female; weighing ~25 g; 6-8 months old; infected i.p. with 104 tachyzoites of different T. gondii strain)[3]
Dosage: 10 mg/kg/d; 40 mg/kg/d; 160 mg/kg/d; 640 mg/kg/d
Administration: p.o.; daily for 10 days
Result: Showed the lowest treatment efficiency for TgCTBr4, the TgCTBr17 strain, whose mortality
reached 100% between 19 and 27 days at the dose of 10 mg/kg/d, 40 mg/kg/d, and160 mg/kg/d.
Significantly reduced the number of brain cysts in mice infected with other T. gondii (TgCTBr) strains, such as TgCTBr1, TgCTBr9, TgCTBr13, TgCTBr17 and TgCTBr25.
Molecular Weight

250.28

Formula

C10H10N4O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(NC1=NC=CC=N1)(C2=CC=C(C=C2)N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Sulfadiazine 100 µg/mL in methanol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfadiazine 100 µg/mL in methanol68-35-9ParasiteBacterialEnvironmental PollutantsEnvironmental ContaminantsGram-positive bacteriaplasmid-carrying bacteriap-aminobenzoic acidGram-negative bacteriasulfonamide-resistance genedihydropteroate synthasedenitrifying bacteriaToxoplasma gondiifolic-acid-metabolism cycleammonia-oxidizing bacteriaInhibitorinhibitorinhibit

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