Cat. No.: HY-B0273B

4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide

Name: 4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide
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SKU: HY-B0273B
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9 Cited Publications

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Based on 9 publication(s) in Google Scholar

Sulfadiazine 100 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadiazine 100 µg/mL in methanol competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine 100 µg/mL in methanol persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine 100 µg/mL in methanol targets Toxoplasma gondii DHPS enzyme. Sulfadiazine 100 µg/mL in methanol can be used for the research of congenital toxoplasmosis and bacterial infection.

For research use only. We do not sell to patients.

CAS No.: 68-35-9
Formula: C₁₀H₁₀N₄O₂S
Molecular Weight:250.28

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide Chemical Structure

CAS No.: 68-35-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (9)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	IC₅₀	>50 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii B1 harboring DHPS Ex2, E474D/Ex4, R560K/Ex5, 580 sil Gly/ A597E/627 sil Glu mutant gene and DHFR Ex3, 156 sil Leu mutant gene infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii B1 harboring DHPS Ex2, E474D/Ex4, R560K/Ex5, 580 sil Gly/ A597E/627 sil Glu mutant gene and DHFR Ex3, 156 sil Leu mutant gene infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	14.95 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii isolate GRE-1995-MAE infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii isolate GRE-1995-MAE infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	16.85 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii isolate GRE-1998-TRA infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii isolate GRE-1998-TRA infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	18.8 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii isolate PSP-2005-MUP infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii isolate PSP-2005-MUP infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	2.95 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii isolate TOU-1998-TRI infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii isolate TOU-1998-TRI infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	4.28 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii ENT harboring DHPS Ex2, E474D/Ex3, 156 sil Leu/Ex4, R560K/Ex5, 580 sil Gly/A597E/627 sil Glu mutant gene and DHFR Ex3, 156 sil Leu mutant gene infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii ENT harboring DHPS Ex2, E474D/Ex3, 156 sil Leu/Ex4, R560K/Ex5, 580 sil Gly/A597E/627 sil Glu mutant gene and DHFR Ex3, 156 sil Leu mutant gene infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	4.9 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii isolate RMS-2003-DJO infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii isolate RMS-2003-DJO infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	5.35 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii isolate GUY-2003-MEL harboring DHPS Ex2, E474D/Ex4, R560K/Ex5, 580 sil Gly/ A597E/627 sil Glu mutant gene and DHFR Ex2, 145 sil Val mutant gene infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii isolate GUY-2003-MEL harboring DHPS Ex2, E474D/Ex4, R560K/Ex5, 580 sil Gly/ A597E/627 sil Glu mutant gene and DHFR Ex2, 145 sil Val mutant gene infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	6.26 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii isolate TRS-2004-REV infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii isolate TRS-2004-REV infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	6.52 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii RH harboring DHPS Ex2, E474D/Ex4, R560K/Ex5, 580 sil Gly; A597E/627 sil Glu mutant gene and DHFR Ex3, 156 sil Leu mutant gene infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii RH harboring DHPS Ex2, E474D/Ex4, R560K/Ex5, 580 sil Gly; A597E/627 sil Glu mutant gene and DHFR Ex3, 156 sil Leu mutant gene infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	6.55 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii ME49 infected in human MRC-5 cells infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii ME49 infected in human MRC-5 cells infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	6.7 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii isolate RMS-2005-HAG infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii isolate RMS-2005-HAG infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	9.25 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii NED infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii NED infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
MRC5	IC₅₀	9.65 mg/L Compound: sulfadiazine, SDZ	Antimicrobial activity against Toxoplasma gondii isolate RMS-1994-LEF harboring DHPS Ex2, E474D/Ex4, R560K/Ex5, 580 sil Gly; A597E/627 sil Glu mutant gene and DHFR Ex3, 204 sil Ala mutant gene infected in human MRC-5 cells after 72 hrs by ELISA Antimicrobial activity against Toxoplasma gondii isolate RMS-1994-LEF harboring DHPS Ex2, E474D/Ex4, R560K/Ex5, 580 sil Gly; A597E/627 sil Glu mutant gene and DHFR Ex3, 204 sil Ala mutant gene infected in human MRC-5 cells after 72 hrs by ELISA	[PMID: 18212105]
Vero	IC₅₀	0.09 mM Compound: Sulfadiazine (SULF)	Compound tested on vero cells infected with Toxoplasma gondii after 24 h Compound tested on vero cells infected with Toxoplasma gondii after 24 h	[PMID: 15863319]
Vero	IC₅₀	0.1 mM Compound: Sulfadiazine (SULF)	Compound tested on intracellular parasites Toxoplasma gondii in vero cells after 24 h Compound tested on intracellular parasites Toxoplasma gondii in vero cells after 24 h	[PMID: 15863319]
Vero	IC₅₀	3 mM Compound: sulphadiazine	Inhibition of Toxoplasma gondii infected in african green monkey Vero cells Inhibition of Toxoplasma gondii infected in african green monkey Vero cells	[PMID: 17905587]
Vero	IC₅₀	8 mM Compound: sulphadiazine	Inhibition of uninfected african green monkey Vero cells Inhibition of uninfected african green monkey Vero cells	[PMID: 17905587]

In Vitro

Sulfadiazine 100 µg/mL in methanol is associated with low sensitivity linked to the novel R265H and I347M mutations in the dhps gene of Toxoplasma gondii strains TgCTBr4 and TgCTBr17^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sulfadiazine (10-640 mg/kg/d; p.o.; daily for 10 days) 100 µg/mL in methanol reduced the number of brain cysts in mice infected with T. gondii (TgCTBr) except for TgCTBr4^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss Webster (female; weighing ~25 g; 6-8 months old; infected i.p. with 10⁴ tachyzoites of different T. gondii strain)^[3]
Dosage:

10 mg/kg/d; 40 mg/kg/d; 160 mg/kg/d; 640 mg/kg/d
Administration:

p.o.; daily for 10 days
Result:

Showed the lowest treatment efficiency for TgCTBr4, the TgCTBr17 strain, whose mortality
reached 100% between 19 and 27 days at the dose of 10 mg/kg/d, 40 mg/kg/d, and160 mg/kg/d.
Significantly reduced the number of brain cysts in mice infected with other T. gondii (TgCTBr) strains, such as TgCTBr1, TgCTBr9, TgCTBr13, TgCTBr17 and TgCTBr25.

Chemical Information

CAS No. 68-35-9
Appearance Solid
Molecular Weight 250.28
Formula C₁₀H₁₀N₄O₂S
Color White to off-white
SMILES

O=S(NC1=NC=CC=N1)(C2=CC=C(C=C2)N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (9)

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Journal Impact Factor

Cell

Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice. [Abstract]

2024 Feb 15;187(4):882-896.e17 PMID: 38295787
Theranostics

Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents. [Abstract]

2022 Jan 1;12(3):1187-1203. PMID: 35154482
Water Res

Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. [Abstract]

2023 Jul 15:240:120110. PMID: 37247434
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Emerg Contam

2026 Feb 23.
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Water

2025 Jun 6.
J Essent Oil Res

2026 Jul 14;38(4):431-445.
Chemosphere

Toxicity evolution and control for the UV/H2O2 degradation of nitrogen-containing heterocyclic compounds: SDZ and PMM. [Abstract]

2023 Oct:338:139541. PMID: 37467855

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (761 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schauss K, et al. Analysis, fate and effects of the antibiotic sulfadiazine in soil ecosystems. TrAC, Trends Anal. Chem. 2009 Mar 1;28(5):612-618.

[2]. Yang JF, et al. Degradation behavior of sulfadiazine in soils under different conditions. J Environ Sci Health B. 2009 Mar;44(3):241-8. [Content Brief]

[3]. Silva LA, et al. Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil. Exp Parasitol. 2019;202:7-14. [Content Brief]

[4]. Kopmann C, et al. Abundance and transferability of antibiotic resistance as related to the fate of sulfadiazine in maize rhizosphere and bulk soil. FEMS Microbiol Ecol. 2013;83(1):125-134. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide

9 Cited Publications

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4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide

Publications Citing Use of MedChemExpress (MCE) 4-Amino-N-(pyrimidin-2-yl)benzenesulfonamide

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