Streptomycin sulfate
Based on 49 publication(s) in Google Scholar
Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.
For research use only. We do not sell to patients.
- Purity: 99.27%
- CAS No.: 3810-74-0
- Formula: C21H42N7O18S1.5
- Molecular Weight:728.69
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Publications Citing Use of MedChemExpress (MCE) Streptomycin sulfate
More- Signal Transduct Target Ther. 2025 Mar 5;10(1):79. [Abstract]
- Cell Host Microbe. 2025 Jun 11;33(6):915-931.e9. [Abstract]
- Autophagy. 2022 Apr;18(4):726-744. [Abstract]
- Adv Sci (Weinh). 2025 Oct 13:e09383. [Abstract]
- Adv Sci (Weinh). 2024 Nov;11(44):e2401931. [Abstract]
- J Adv Res. 2026 Apr 13:S2090-1232(26)00337-1. [Abstract]
- J Nanobiotechnology. 2024 Nov 30;22(1):744. [Abstract]
- Redox Biol. 2024 Jul 23:75:103284. [Abstract]
- J Control Release. 2024 Oct 26:S0168-3659(24)00725-9. [Abstract]
- Gut Microbes. 2024 Jan-Dec;16(1):2390164. [Abstract]
- Research (Wash D C). 2024 Jul 16:7:0415. [Abstract]
- Cell Rep Med. 2023 Dec 19;4(12):101340. [Abstract]
- Int J Biol Sci. 2024 Sep 3;20(12):4635-4653. [Abstract]
- Food Chem. 2023 Mar 1:403:134399. [Abstract]
- Genome Biol. 2023 Apr 30;24(1):98. [Abstract]
- NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111. [Abstract]
- Cancer Biol Med. 2026 Feb 16;23(1):133-153. [Abstract]
- ACS Appl Mater Interfaces. 2024 Sep 4;16(35):46123-46132. [Abstract]
- Free Radic Biol Med. 2023 Jul:203:86-101. [Abstract]
- Curr Res Food Sci. 2025 May 16:10:101084. [Abstract]
- J Med Chem. 2025 Mar 27;68(6):6339-6360. [Abstract]
- J Med Chem. 2024 Sep 12;67(17):15387-15410. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Food Funct. 2025 Feb 3;16(3):1041-1059. [Abstract]
- Mar Life Sci Technol. 2025 May 12;7(2):256-270. [Abstract]
- Life Sci. 2020 Nov 15;261:118473. [Abstract]
- Eur J Pharmacol. 2026 Jul 10:1029:179012. [Abstract]
- Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]
- Neuropharmacology. 2026 Jul 1:292:110950. [Abstract]
- mLife. 2025 Apr 15;4(2):155-168. [Abstract]
- Cancers (Basel). 2022 Sep 28;14(19):4740. [Abstract]
- ACS Omega. 2020 Nov 15;5(46):29935-29942. [Abstract]
- Drug Dev Res. 2022 Apr;83(2):389-396. [Abstract]
- Transl Oncol. 2025 May:55:102355. [Abstract]
- APL Bioeng. 2022 Nov 21;6(4):046106. [Abstract]
- Microbiol Spectr. 2025 Aug 29:e0059025. [Abstract]
- Anal Bioanal Chem. 2025 Jan;417(3):615-625. [Abstract]
- ACS Chem Biol. 2022 Jan 21;17(1):39-53. [Abstract]
- Aquac Rep. 2026 Apr 28;48:103625.
- Int Dent J. 2025 Jun 9;75(4):100850. [Abstract]
- Mol Med Rep. 2021 Dec;24(6):843. [Abstract]
- Mol Med Rep. 2021 Dec;24(6):832. [Abstract]
- BMC Cancer. 2023 Mar 14;23(1):241. [Abstract]
- Dis Model Mech. 2021 Dec 1;14(12):dmm049145. [Abstract]
- Water. 2025 Jun 6.
- J Orthop Surg Res. 2022 Oct 28;17(1):468. [Abstract]
- Int J Immunopathol Pharmacol. 2025 Jan-Dec:39:3946320251348715. [Abstract]
- PLoS One. 2020 Sep 3;15(9):e0235824. [Abstract]
- In Vitro Cell Dev Biol Anim. 2024 Oct;60(9):1046-1057. [Abstract]
Customer Validation & Images
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Microbiological Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
All Antibiotic Isoforms
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Biological Activity
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Aminoglycoside |
Strain RB1 shows enhanced susceptibility to streptomycin as the concentration of CV in the growth medium increases. As the CV concentration in the growth medium increases, both cytochrome aa3 levels and streptomycin susceptibility increase. Cytochrome aa3 is necessary for accumulation of streptomycin by B. subtilis[1]. Streptomycin influences tRNA selection. Streptomycin resistance mutations generally map to protein S12 and most of these variants exhibit increased levels of discrimination in the tRNA selection process[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 3810-74-0
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Appearance Solid
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Molecular Weight 728.69
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Formula C21H42N7O18S1.5
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Color White to off-white
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SMILES
O[C@@]1(C=O)[C@H]([C@@H](O[C@H]1C)O[C@]([C@@H]([C@@H](O)[C@@H]2NC(N)=N)O)([H])[C@H]([C@@H]2O)NC(N)=N)O[C@@](O[C@@H](CO)[C@H](O)[C@H]3O)([H])[C@H]3NC.[1.5H2SO4]
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Initial Source
Streptomyces
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (49)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness. [Abstract]2025 Mar 5;10(1):79. PMID: 40038255 -
Cell Host Microbe
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy. [Abstract]2025 Jun 11;33(6):915-931.e9. PMID: 40441145 -
Autophagy
2022 Apr;18(4):726-744. PMID: 34282994 -
Adv Sci (Weinh)
Faecalibaculum rodentium Alleviates Ionizing Radiation-Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate. [Abstract]2025 Oct 13:e09383. PMID: 41082369 -
Adv Sci (Weinh)
The Thyroid Hormone Analog GC-1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization. [Abstract]2024 Nov;11(44):e2401931. PMID: 39373388 -
J Adv Res
Portulaca oleracea L. polysaccharide alleviates colitis-associated bone loss through Muribaculaceae-enriched gut microbiota and elevated colonic melatonin. [Abstract]2026 Apr 13:S2090-1232(26)00337-1. PMID: 41980626 -
J Nanobiotechnology
Enhancing radiotherapy in triple-negative breast cancer with hesperetin-induced ferroptosis via AURKA targeting nanocomposites. [Abstract]2024 Nov 30;22(1):744. PMID: 39614277 -
Redox Biol
Plasma-generated RONS in liquid transferred into cryo-microneedles patch for skin treatment of melanoma. [Abstract]2024 Jul 23:75:103284. PMID: 39059203 -
J Control Release
2024 Oct 26:S0168-3659(24)00725-9. PMID: 39490420 -
Gut Microbes
Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling. [Abstract]2024 Jan-Dec;16(1):2390164. PMID: 39154362 -
Research (Wash D C)
Bacillus siamensis Targeted Screening from Highly Colitis-Resistant Pigs Can Alleviate Ulcerative Colitis in Mice. [Abstract]2024 Jul 16:7:0415. PMID: 39015206
Streptomycin sulfate purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2024 Jul 16:7:0415. [Abstract]
Streptomycin (32 mg/L; 37 ℃; 20 h). Antibiotic sensitivity of the MZ16 strain. In susceptibility tests with 10 antibiotics, MZ16 was found to be susceptible to all the antibiotics tested.
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Cell Rep Med
Attenuation of allergen-specific immunotherapy for atopic dermatitis by ectopic colonization of Brevundimonas vesicularis in the intestine. [Abstract]2023 Dec 19;4(12):101340. PMID: 38118418 -
Int J Biol Sci
Darolutamide-mediated phospholipid remodeling induces ferroptosis through the SREBP1-FASN axis in prostate cancer. [Abstract]2024 Sep 3;20(12):4635-4653. PMID: 39309439 -
Food Chem
Electrochemical sensor for detecting streptomycin in milk based on label-free aptamer chain and magnetic adsorption. [Abstract]2023 Mar 1:403:134399. PMID: 36182859
Streptomycin sulfate purchased from MedChemExpress. Usage Cited in: Food Chem. 2023 Mar 1:403:134399. [Abstract]
DPV of STP-MMCM/MGCE at different concentrations of Streptomycin (STR) (0.172–17.2 × 105 nM) and the linear relationship between operating current and different Streptomycin (STR) concentrations were investigated. The response peak current of STP/MMCM/MGCE showed a good linear relationship with STR concentration, and there were two linear ranges on the STP/MMCM/MGCE surface.
Streptomycin sulfate purchased from MedChemExpress. Usage Cited in: Food Chem. 2023 Mar 1:403:134399. [Abstract]
Selectivity assessment of the aptasensor was conducted. The DPV peak current changed in the presence of the same concentration of structural analogues of Streptomycin (S) (0.01 mg/mL), such as kanamycin (K), gentamicin (G), and tobramycin (T). The change of peak current was not particularly obvious when the concentration of the interfering substance (1 mg/mL) was 100 times higher than that of streptomycin (S).
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Genome Biol
Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota. [Abstract]2023 Apr 30;24(1):98. PMID: 37122023 -
NPJ Biofilms Microbiomes
Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function. [Abstract]2024 Oct 28;10(1):111. PMID: 39468065 -
Cancer Biol Med
Antitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression. [Abstract]2026 Feb 16;23(1):133-153. PMID: 41700809 -
ACS Appl Mater Interfaces
Multiple RONS-Loaded Plasma-Activated Ice Microneedle Patches for Transdermal Treatment of Psoriasis. [Abstract]2024 Sep 4;16(35):46123-46132. PMID: 39180585 -
Free Radic Biol Med
Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma. [Abstract]2023 Jul:203:86-101. PMID: 37044150 -
Curr Res Food Sci
Gallic acid prevents obesity in mice on a high-fat diet via the gut microbiota-adipose tissue axis. [Abstract]2025 May 16:10:101084. PMID: 40491530 -
J Med Chem
Modular Synthesis of Bioactive Selenoheterocycles for Efficient Cancer Therapy via Electrochemical Selenylation/Cyclization. [Abstract]2025 Mar 27;68(6):6339-6360. PMID: 40063343 -
J Med Chem
2024 Sep 12;67(17):15387-15410. PMID: 39159497 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Food Funct
Dietary limonin alleviates Salmonella Typhimurium-induced colitis via dual targeting virulence SopB and SopE2 and inhibiting RAC1/CDC42/Arp2/3 pathway and regulating gut microbiota. [Abstract]2025 Feb 3;16(3):1041-1059. PMID: 39820212 -
Mar Life Sci Technol
2025 May 12;7(2):256-270. PMID: 40417248 -
Life Sci
Electroacupuncture preserves intestinal barrier integrity through modulating the gut microbiota in DSS-induced chronic colitis. [Abstract]2020 Nov 15;261:118473. PMID: 32971101 -
Eur J Pharmacol
Trifluoperazine induces ferroptosis in acute myeloid leukemia by suppressing the Nrf2/SLC7A11/GPX4 axis. [Abstract]2026 Jul 10:1029:179012. PMID: 42178012 -
Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2025 Dec 21:170:116080. PMID: 41429063 -
Neuropharmacology
Novel mechanism of hypidone hydrochloride (YL-0919) in Parkinson's disease: inhibiting neuronal ferroptosis by targeting the Sigma1R-PI3K-AKT-ACSL4 axis. [Abstract]2026 Jul 1:292:110950. PMID: 41887568 -
mLife
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria. [Abstract]2025 Apr 15;4(2):155-168. PMID: 40313980 -
Cancers (Basel)
LncRNA SNHG1 Facilitates Tumor Proliferation and Represses Apoptosis by Regulating PPARγ Ubiquitination in Bladder Cancer. [Abstract]2022 Sep 28;14(19):4740. PMID: 36230661 -
ACS Omega
Computational Approaches to Identify Molecules Binding to Mycobacterium tuberculosis KasA. [Abstract]2020 Nov 15;5(46):29935-29942. PMID: 33251429 -
Drug Dev Res
Naringenin inhibits autophagy and epithelial-mesenchymal transition of human lens epithelial cells by regulating the Smad2/3 pathway. [Abstract]2022 Apr;83(2):389-396. PMID: 34402084 -
Transl Oncol
Tubeimoside I induces mitophagy by activating the PINK1/Parkin/Mfn2 signaling pathway in acute myeloid leukemia cells. [Abstract]2025 May:55:102355. PMID: 40112502 -
APL Bioeng
Glutathione-sensitive nanoparticles enhance the combined therapeutic effect of checkpoint kinase 1 inhibitor and cisplatin in prostate cancer. [Abstract]2022 Nov 21;6(4):046106. PMID: 36440378 -
Microbiol Spectr
2025 Aug 29:e0059025. PMID: 40879403 -
Anal Bioanal Chem
2025 Jan;417(3):615-625. PMID: 39613988 -
ACS Chem Biol
Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. [Abstract]2022 Jan 21;17(1):39-53. PMID: 34908399 -
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Int Dent J
VPA Enhances Pulp Regeneration by Regulating LPS-Induced Human Dental Pulp Stem Cells Odontogenic Differentiation. [Abstract]2025 Jun 9;75(4):100850. PMID: 40494210 -
Mol Med Rep
Long non-‑coding RNA SNHG16 functions as a tumor activator by sponging miR‑373‑3p to regulate the TGF‑β‑R2/SMAD pathway in prostate cancer. [Abstract]2021 Dec;24(6):843. PMID: 34643247 -
Mol Med Rep
Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway. [Abstract]2021 Dec;24(6):832. PMID: 34590155 -
BMC Cancer
Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma. [Abstract]2023 Mar 14;23(1):241. PMID: 36918801 -
Dis Model Mech
An anti-tuberculosis compound screen using a zebrafish infection model identifies an aspartyl-tRNA synthetase inhibitor. [Abstract]2021 Dec 1;14(12):dmm049145. PMID: 34643222 -
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J Orthop Surg Res
Deer antler extract promotes tibia fracture healing in mice by activating BMP-2/SMAD4 signaling pathway. [Abstract]2022 Oct 28;17(1):468. PMID: 36307889 -
Int J Immunopathol Pharmacol
Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice. [Abstract]2025 Jan-Dec:39:3946320251348715. PMID: 40518910 -
PLoS One
Mechanical stretching of pulmonary vein stimulates matrix metalloproteinase-9 and transforming growth factor-β1 through stretch-activated channel/MAPK pathways in pulmonary hypertension due to left heart disease model rats. [Abstract]2020 Sep 3;15(9):e0235824. PMID: 32881898 -
In Vitro Cell Dev Biol Anim
Liraglutide ameliorates high glucose-induced vascular endothelial injury through TRIB3/NF-κB signaling pathway. [Abstract]2024 Oct;60(9):1046-1057. PMID: 39039329
Solvent & Solubility
H2O : ≥ 100 mg/mL (137.23 mM)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (137.23 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (281 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. McEnroe AS, et al. Correlation between cytochrome aa3 concentrations and streptomycin accumulation in Bacillus subtilis. Antimicrob Agents Chemother. 1984 Oct;26(4):507-12. [Content Brief]
[2]. Sharma, D., et al., Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol, 2007. 374(4): p. 1065-76. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3723 mL | 6.8616 mL | 13.7233 mL | 34.3081 mL |
| 5 mM | 0.2745 mL | 1.3723 mL | 2.7447 mL | 6.8616 mL | |
| 10 mM | 0.1372 mL | 0.6862 mL | 1.3723 mL | 3.4308 mL | |
| 15 mM | 0.0915 mL | 0.4574 mL | 0.9149 mL | 2.2872 mL | |
| 20 mM | 0.0686 mL | 0.3431 mL | 0.6862 mL | 1.7154 mL | |
| 25 mM | 0.0549 mL | 0.2745 mL | 0.5489 mL | 1.3723 mL | |
| 30 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1436 mL | |
| 40 mM | 0.0343 mL | 0.1715 mL | 0.3431 mL | 0.8577 mL | |
| 50 mM | 0.0274 mL | 0.1372 mL | 0.2745 mL | 0.6862 mL | |
| 60 mM | 0.0229 mL | 0.1144 mL | 0.2287 mL | 0.5718 mL | |
| 80 mM | 0.0172 mL | 0.0858 mL | 0.1715 mL | 0.4289 mL | |
| 100 mM | 0.0137 mL | 0.0686 mL | 0.1372 mL | 0.3431 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Streptomycin sulfate Related Classifications
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