Streptomycin sulfate

Name: Streptomycin sulfate
Brand: MedChemExpress
SKU: HY-B0472
Rating: 5.0 (46 reviews)

Cat. No.: HY-B0472 Purity: 99.27%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.

For research use only. We do not sell to patients.

CAS No. : 3810-74-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

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Customer Review

Based on 46 publication(s) in Google Scholar

Other Forms of Streptomycin sulfate:

Streptomycin In-stock
Streptomycin sulfate (Standard) Get quote

46 Publications Citing Use of MCE Streptomycin sulfate

Microbiological Assay

Bio/Physico-chemical Assay

: Streptomycin sulfate purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2024 Jul 16:7:0415. [Abstract]; Streptomycin (32 mg/L; 37 ℃; 20 h). Antibiotic sensitivity of the MZ16 strain. In susceptibility tests with 10 antibiotics, MZ16 was found to be susceptible to all the antibiotics tested.

: Streptomycin sulfate purchased from MedChemExpress. Usage Cited in: Food Chem. 2023 Mar 1:403:134399. [Abstract]; DPV of STP-MMCM/MGCE at different concentrations of Streptomycin (STR) (0.172–17.2 × 10⁵ nM) and the linear relationship between operating current and different Streptomycin (STR) concentrations were investigated. The response peak current of STP/MMCM/MGCE showed a good linear relationship with STR concentration, and there were two linear ranges on the STP/MMCM/MGCE surface.

: Streptomycin sulfate purchased from MedChemExpress. Usage Cited in: Food Chem. 2023 Mar 1:403:134399. [Abstract]; Selectivity assessment of the aptasensor was conducted. The DPV peak current changed in the presence of the same concentration of structural analogues of Streptomycin (S) (0.01 mg/mL), such as kanamycin (K), gentamicin (G), and tobramycin (T). The change of peak current was not particularly obvious when the concentration of the interfering substance (1 mg/mL) was 100 times higher than that of streptomycin (S).

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis.

IC₅₀ & Target

Aminoglycoside

In Vitro

Strain RB1 shows enhanced susceptibility to streptomycin as the concentration of CV in the growth medium increases. As the CV concentration in the growth medium increases, both cytochrome aa3 levels and streptomycin susceptibility increase. Cytochrome aa3 is necessary for accumulation of streptomycin by B. subtilis^[1]. Streptomycin influences tRNA selection. Streptomycin resistance mutations generally map to protein S12 and most of these variants exhibit increased levels of discrimination in the tRNA selection process^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

728.69

Formula

C₂₁H₄₂N₇O₁₈S_1.5

CAS No.

3810-74-0

Appearance

Solid

Color

White to off-white

SMILES

O[C@@]1(C=O)[C@H]([C@@H](O[C@H]1C)O[C@]([C@@H]([C@@H](O)[C@@H]2NC(N)=N)O)([H])[C@H]([C@@H]2O)NC(N)=N)O[C@@](O[C@@H](CO)[C@H](O)[C@H]3O)([H])[C@H]3NC.[1.5H2SO4]

Structure Classification

Initial Source

Microorganisms

Streptomyces

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (137.23 mM)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3723 mL	6.8616 mL	13.7233 mL
5 mM	0.2745 mL	1.3723 mL	2.7447 mL
10 mM	0.1372 mL	0.6862 mL	1.3723 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (137.23 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.27%

Select Batch:

Data Sheet (281 KB) SDS (419 KB)

COA (262 KB) HNMR (321 KB) RP-HPLC (240 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. McEnroe AS, et al. Correlation between cytochrome aa3 concentrations and streptomycin accumulation in Bacillus subtilis. Antimicrob Agents Chemother. 1984 Oct;26(4):507-12. [Content Brief]

[2]. Sharma, D., et al., Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol, 2007. 374(4): p. 1065-76. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.3723 mL	6.8616 mL	13.7233 mL	34.3081 mL
	5 mM	0.2745 mL	1.3723 mL	2.7447 mL	6.8616 mL
	10 mM	0.1372 mL	0.6862 mL	1.3723 mL	3.4308 mL
	15 mM	0.0915 mL	0.4574 mL	0.9149 mL	2.2872 mL
	20 mM	0.0686 mL	0.3431 mL	0.6862 mL	1.7154 mL
	25 mM	0.0549 mL	0.2745 mL	0.5489 mL	1.3723 mL
	30 mM	0.0457 mL	0.2287 mL	0.4574 mL	1.1436 mL
	40 mM	0.0343 mL	0.1715 mL	0.3431 mL	0.8577 mL
	50 mM	0.0274 mL	0.1372 mL	0.2745 mL	0.6862 mL
	60 mM	0.0229 mL	0.1144 mL	0.2287 mL	0.5718 mL
	80 mM	0.0172 mL	0.0858 mL	0.1715 mL	0.4289 mL
	100 mM	0.0137 mL	0.0686 mL	0.1372 mL	0.3431 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.