Streptomycin
Based on 46 publication(s) in Google Scholar
Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 57-92-1
- Formula: C21H39N7O12
- Molecular Weight:581.57
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Publications Citing Use of MedChemExpress (MCE) Streptomycin
More- Signal Transduct Target Ther. 2025 Mar 5;10(1):79. [Abstract]
- Cell Host Microbe. 2025 Jun 11;33(6):915-931.e9. [Abstract]
- Autophagy. 2022 Apr;18(4):726-744. [Abstract]
- Adv Sci (Weinh). 2025 Oct 13:e09383. [Abstract]
- Adv Sci (Weinh). 2024 Nov;11(44):e2401931. [Abstract]
- J Nanobiotechnology. 2024 Nov 30;22(1):744. [Abstract]
- Redox Biol. 2024 Jul 23:75:103284. [Abstract]
- J Control Release. 2024 Oct 26:S0168-3659(24)00725-9. [Abstract]
- Gut Microbes. 2024 Jan-Dec;16(1):2390164. [Abstract]
- Research (Wash D C). 2024 Jul 16:7:0415. [Abstract]
- Cell Rep Med. 2023 Dec 19;4(12):101340. [Abstract]
- Int J Biol Sci. 2024 Sep 3;20(12):4635-4653. [Abstract]
- Food Chem. 2023 Mar 1:403:134399. [Abstract]
- Genome Biol. 2023 Apr 30;24(1):98. [Abstract]
- NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111. [Abstract]
- Cancer Biol Med. 2026 Feb 16;23(1):133-153. [Abstract]
- ACS Appl Mater Interfaces. 2024 Sep 4;16(35):46123-46132. [Abstract]
- Free Radic Biol Med. 2023 Jul:203:86-101. [Abstract]
- Curr Res Food Sci. 2025 May 16:10:101084. [Abstract]
- J Med Chem. 2025 Mar 27;68(6):6339-6360. [Abstract]
- J Med Chem. 2024 Sep 12;67(17):15387-15410. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Food Funct. 2025 Feb 3;16(3):1041-1059. [Abstract]
- Mar Life Sci Technol. 2025 May 12;7(2):256-270. [Abstract]
- Life Sci. 2020 Nov 15;261:118473. [Abstract]
- Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]
- Neuropharmacology. 2026 Jul 1:292:110950. [Abstract]
- mLife. 2025 Apr 15;4(2):155-168. [Abstract]
- Cancers (Basel). 2022 Sep 28;14(19):4740. [Abstract]
- ACS Omega. 2020 Nov 15;5(46):29935-29942. [Abstract]
- Drug Dev Res. 2022 Apr;83(2):389-396. [Abstract]
- Transl Oncol. 2025 May:55:102355. [Abstract]
- APL Bioeng. 2022 Nov 21;6(4):046106. [Abstract]
- Microbiol Spectr. 2025 Aug 29:e0059025. [Abstract]
- Anal Bioanal Chem. 2025 Jan;417(3):615-625. [Abstract]
- ACS Chem Biol. 2022 Jan 21;17(1):39-53. [Abstract]
- Int Dent J. 2025 Jun 9;75(4):100850. [Abstract]
- Mol Med Rep. 2021 Dec;24(6):832. [Abstract]
- Mol Med Rep. 2021 Dec;24(6):843. [Abstract]
- BMC Cancer. 2023 Mar 14;23(1):241. [Abstract]
- Dis Model Mech. 2021 Dec 1;14(12):dmm049145. [Abstract]
- Water. 2025 Jun 6.
- J Orthop Surg Res. 2022 Oct 28;17(1):468. [Abstract]
- Int J Immunopathol Pharmacol. 2025 Jan-Dec:39:3946320251348715. [Abstract]
- PLoS One. 2020 Sep 3;15(9):e0235824. [Abstract]
- In Vitro Cell Dev Biol Anim. 2024 Oct;60(9):1046-1057. [Abstract]
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Microbiological Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
All Antibiotic Isoforms
More
Biological Activity
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Aminoglycoside |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774.A1 | CC50 |
>1000 μg/mL
Compound: Streptomycin
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Cytotoxicity against mouse J774A1 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against mouse J774A1 cells after 24 to 72 hrs by MTT assay
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[PMID: 20934344] |
| Sf21 | IC50 |
>1000 μM
Compound: Streptomycin
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Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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[PMID: 21965623] |
| Sf21 | IC50 |
>1000 μM
Compound: Streptomycin
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Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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[PMID: 21965623] |
| THP-1 | IC50 |
>258 μM
Compound: Streptomycin
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Cytotoxicity against human THP1 cells assessed as growth inhibition after 24 to 48 hrs by MTT assay
Cytotoxicity against human THP1 cells assessed as growth inhibition after 24 to 48 hrs by MTT assay
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[PMID: 29529504] |
| Vero | IC50 |
>100 μM
Compound: streptomycin
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Cytotoxicity against Vero cells
Cytotoxicity against Vero cells
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[PMID: 17562368] |
| Vero | IC50 |
>120 μg/mL
Compound: streptomycin
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Cytotoxicity against Vero cells after 48 hrs by XTT method
Cytotoxicity against Vero cells after 48 hrs by XTT method
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[PMID: 17888665] |
| Vero | IC50 |
>50 μg/mL
Compound: Streptomycin
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Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay
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[PMID: 24044875] |
| Vero | IC50 |
>100 μg/mL
Compound: SM
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Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay
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[PMID: 24087924] |
Chemical Information
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CAS No. 57-92-1
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Appearance Solid
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Molecular Weight 581.57
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Formula C21H39N7O12
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Color White to off-white
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SMILES
N=C(N)N[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)O)NC(N)=N)O)[C@H]1O[C@H](O[C@H]([C@]2(O)C=O)C)[C@@H]2O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC
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Synonyms
Agrept; Agrimycin; Streptomycin A
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (46)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness. [Abstract]2025 Mar 5;10(1):79. PMID: 40038255 -
Cell Host Microbe
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy. [Abstract]2025 Jun 11;33(6):915-931.e9. PMID: 40441145 -
Autophagy
2022 Apr;18(4):726-744. PMID: 34282994 -
Adv Sci (Weinh)
Faecalibaculum rodentium Alleviates Ionizing Radiation-Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate. [Abstract]2025 Oct 13:e09383. PMID: 41082369 -
Adv Sci (Weinh)
The Thyroid Hormone Analog GC-1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization. [Abstract]2024 Nov;11(44):e2401931. PMID: 39373388 -
J Nanobiotechnology
Enhancing radiotherapy in triple-negative breast cancer with hesperetin-induced ferroptosis via AURKA targeting nanocomposites. [Abstract]2024 Nov 30;22(1):744. PMID: 39614277 -
Redox Biol
Plasma-generated RONS in liquid transferred into cryo-microneedles patch for skin treatment of melanoma. [Abstract]2024 Jul 23:75:103284. PMID: 39059203 -
J Control Release
2024 Oct 26:S0168-3659(24)00725-9. PMID: 39490420 -
Gut Microbes
Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling. [Abstract]2024 Jan-Dec;16(1):2390164. PMID: 39154362 -
Research (Wash D C)
Bacillus siamensis Targeted Screening from Highly Colitis-Resistant Pigs Can Alleviate Ulcerative Colitis in Mice. [Abstract]2024 Jul 16:7:0415. PMID: 39015206
Streptomycin purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2024 Jul 16:7:0415. [Abstract]
Streptomycin (32 mg/L; 37 ℃; 20 h). Antibiotic sensitivity of the MZ16 strain. In susceptibility tests with 10 antibiotics, MZ16 was found to be susceptible to all the antibiotics tested.
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Cell Rep Med
Attenuation of allergen-specific immunotherapy for atopic dermatitis by ectopic colonization of Brevundimonas vesicularis in the intestine. [Abstract]2023 Dec 19;4(12):101340. PMID: 38118418 -
Int J Biol Sci
Darolutamide-mediated phospholipid remodeling induces ferroptosis through the SREBP1-FASN axis in prostate cancer. [Abstract]2024 Sep 3;20(12):4635-4653. PMID: 39309439 -
Food Chem
Electrochemical sensor for detecting streptomycin in milk based on label-free aptamer chain and magnetic adsorption. [Abstract]2023 Mar 1:403:134399. PMID: 36182859
Streptomycin purchased from MedChemExpress. Usage Cited in: Food Chem. 2023 Mar 1:403:134399. [Abstract]
DPV of STP-MMCM/MGCE at different concentrations of Streptomycin (STR) (0.172–17.2 × 105 nM) and the linear relationship between operating current and different Streptomycin (STR) concentrations were investigated. The response peak current of STP/MMCM/MGCE showed a good linear relationship with STR concentration, and there were two linear ranges on the STP/MMCM/MGCE surface.
Streptomycin purchased from MedChemExpress. Usage Cited in: Food Chem. 2023 Mar 1:403:134399. [Abstract]
Selectivity assessment of the aptasensor was conducted. The DPV peak current changed in the presence of the same concentration of structural analogues of Streptomycin (S) (0.01 mg/mL), such as kanamycin (K), gentamicin (G), and tobramycin (T). The change of peak current was not particularly obvious when the concentration of the interfering substance (1 mg/mL) was 100 times higher than that of streptomycin (S).
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Genome Biol
Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota. [Abstract]2023 Apr 30;24(1):98. PMID: 37122023 -
NPJ Biofilms Microbiomes
Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function. [Abstract]2024 Oct 28;10(1):111. PMID: 39468065 -
Cancer Biol Med
Antitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression. [Abstract]2026 Feb 16;23(1):133-153. PMID: 41700809 -
ACS Appl Mater Interfaces
Multiple RONS-Loaded Plasma-Activated Ice Microneedle Patches for Transdermal Treatment of Psoriasis. [Abstract]2024 Sep 4;16(35):46123-46132. PMID: 39180585 -
Free Radic Biol Med
Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma. [Abstract]2023 Jul:203:86-101. PMID: 37044150 -
Curr Res Food Sci
Gallic acid prevents obesity in mice on a high-fat diet via the gut microbiota-adipose tissue axis. [Abstract]2025 May 16:10:101084. PMID: 40491530 -
J Med Chem
Modular Synthesis of Bioactive Selenoheterocycles for Efficient Cancer Therapy via Electrochemical Selenylation/Cyclization. [Abstract]2025 Mar 27;68(6):6339-6360. PMID: 40063343 -
J Med Chem
2024 Sep 12;67(17):15387-15410. PMID: 39159497 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Food Funct
Dietary limonin alleviates Salmonella Typhimurium-induced colitis via dual targeting virulence SopB and SopE2 and inhibiting RAC1/CDC42/Arp2/3 pathway and regulating gut microbiota. [Abstract]2025 Feb 3;16(3):1041-1059. PMID: 39820212 -
Mar Life Sci Technol
2025 May 12;7(2):256-270. PMID: 40417248 -
Life Sci
Electroacupuncture preserves intestinal barrier integrity through modulating the gut microbiota in DSS-induced chronic colitis. [Abstract]2020 Nov 15;261:118473. PMID: 32971101 -
Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2025 Dec 21:170:116080. PMID: 41429063 -
Neuropharmacology
Novel mechanism of hypidone hydrochloride (YL-0919) in Parkinson's disease: inhibiting neuronal ferroptosis by targeting the Sigma1R-PI3K-AKT-ACSL4 axis. [Abstract]2026 Jul 1:292:110950. PMID: 41887568 -
mLife
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria. [Abstract]2025 Apr 15;4(2):155-168. PMID: 40313980 -
Cancers (Basel)
LncRNA SNHG1 Facilitates Tumor Proliferation and Represses Apoptosis by Regulating PPARγ Ubiquitination in Bladder Cancer. [Abstract]2022 Sep 28;14(19):4740. PMID: 36230661 -
ACS Omega
Computational Approaches to Identify Molecules Binding to Mycobacterium tuberculosis KasA. [Abstract]2020 Nov 15;5(46):29935-29942. PMID: 33251429 -
Drug Dev Res
Naringenin inhibits autophagy and epithelial-mesenchymal transition of human lens epithelial cells by regulating the Smad2/3 pathway. [Abstract]2022 Apr;83(2):389-396. PMID: 34402084 -
Transl Oncol
Tubeimoside I induces mitophagy by activating the PINK1/Parkin/Mfn2 signaling pathway in acute myeloid leukemia cells. [Abstract]2025 May:55:102355. PMID: 40112502 -
APL Bioeng
Glutathione-sensitive nanoparticles enhance the combined therapeutic effect of checkpoint kinase 1 inhibitor and cisplatin in prostate cancer. [Abstract]2022 Nov 21;6(4):046106. PMID: 36440378 -
Microbiol Spectr
2025 Aug 29:e0059025. PMID: 40879403 -
Anal Bioanal Chem
2025 Jan;417(3):615-625. PMID: 39613988 -
ACS Chem Biol
Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. [Abstract]2022 Jan 21;17(1):39-53. PMID: 34908399 -
Int Dent J
VPA Enhances Pulp Regeneration by Regulating LPS-Induced Human Dental Pulp Stem Cells Odontogenic Differentiation. [Abstract]2025 Jun 9;75(4):100850. PMID: 40494210 -
Mol Med Rep
Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway. [Abstract]2021 Dec;24(6):832. PMID: 34590155 -
Mol Med Rep
Long non-‑coding RNA SNHG16 functions as a tumor activator by sponging miR‑373‑3p to regulate the TGF‑β‑R2/SMAD pathway in prostate cancer. [Abstract]2021 Dec;24(6):843. PMID: 34643247 -
BMC Cancer
Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma. [Abstract]2023 Mar 14;23(1):241. PMID: 36918801 -
Dis Model Mech
An anti-tuberculosis compound screen using a zebrafish infection model identifies an aspartyl-tRNA synthetase inhibitor. [Abstract]2021 Dec 1;14(12):dmm049145. PMID: 34643222 -
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J Orthop Surg Res
Deer antler extract promotes tibia fracture healing in mice by activating BMP-2/SMAD4 signaling pathway. [Abstract]2022 Oct 28;17(1):468. PMID: 36307889 -
Int J Immunopathol Pharmacol
Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice. [Abstract]2025 Jan-Dec:39:3946320251348715. PMID: 40518910 -
PLoS One
Mechanical stretching of pulmonary vein stimulates matrix metalloproteinase-9 and transforming growth factor-β1 through stretch-activated channel/MAPK pathways in pulmonary hypertension due to left heart disease model rats. [Abstract]2020 Sep 3;15(9):e0235824. PMID: 32881898 -
In Vitro Cell Dev Biol Anim
Liraglutide ameliorates high glucose-induced vascular endothelial injury through TRIB3/NF-κB signaling pathway. [Abstract]2024 Oct;60(9):1046-1057. PMID: 39039329
Solvent & Solubility
H2O : 125 mg/mL (214.94 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. J DAVIES, et al. STREPTOMYCIN, SUPPRESSION, AND THE CODE. Proc Natl Acad Sci U S A. 1964 May;51(5):883-90. [Content Brief]
[2]. Deisy M G C Rocha, et al. The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem. Genes (Basel). 2021 Dec 17;12(12):2003. [Content Brief]
[3]. Mandeep Singh, et al. Streptomycin sulphate loaded solid lipid nanoparticles show enhanced uptake in macrophage, lower MIC in Mycobacterium and improved oral bioavailability. Eur J Pharm Biopharm. 2021 Mar;160:100-124. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7195 mL | 8.5974 mL | 17.1948 mL | 42.9871 mL |
| 5 mM | 0.3439 mL | 1.7195 mL | 3.4390 mL | 8.5974 mL | |
| 10 mM | 0.1719 mL | 0.8597 mL | 1.7195 mL | 4.2987 mL | |
| 15 mM | 0.1146 mL | 0.5732 mL | 1.1463 mL | 2.8658 mL | |
| 20 mM | 0.0860 mL | 0.4299 mL | 0.8597 mL | 2.1494 mL | |
| 25 mM | 0.0688 mL | 0.3439 mL | 0.6878 mL | 1.7195 mL | |
| 30 mM | 0.0573 mL | 0.2866 mL | 0.5732 mL | 1.4329 mL | |
| 40 mM | 0.0430 mL | 0.2149 mL | 0.4299 mL | 1.0747 mL | |
| 50 mM | 0.0344 mL | 0.1719 mL | 0.3439 mL | 0.8597 mL | |
| 60 mM | 0.0287 mL | 0.1433 mL | 0.2866 mL | 0.7165 mL | |
| 80 mM | 0.0215 mL | 0.1075 mL | 0.2149 mL | 0.5373 mL | |
| 100 mM | 0.0172 mL | 0.0860 mL | 0.1719 mL | 0.4299 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.