Streptomycin (Synonyms: Agrept; Agrimycin; Streptomycin A)

Name: Streptomycin
Brand: MedChemExpress
SKU: HY-B1906
Rating: 5.0 (46 reviews)

Cat. No.: HY-B1906 Purity: 99.91%: Data Sheet
COA

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Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .

For research use only. We do not sell to patients.

CAS No. : 57-92-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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Customer Review

Based on 46 publication(s) in Google Scholar

Other Forms of Streptomycin:

46 Publications Citing Use of MCE Streptomycin

Microbiological Assay

Bio/Physico-chemical Assay

: Streptomycin purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2024 Jul 16:7:0415. [Abstract]; Streptomycin (32 mg/L; 37 ℃; 20 h). Antibiotic sensitivity of the MZ16 strain. In susceptibility tests with 10 antibiotics, MZ16 was found to be susceptible to all the antibiotics tested.

: Streptomycin purchased from MedChemExpress. Usage Cited in: Food Chem. 2023 Mar 1:403:134399. [Abstract]; DPV of STP-MMCM/MGCE at different concentrations of Streptomycin (STR) (0.172–17.2 × 10⁵ nM) and the linear relationship between operating current and different Streptomycin (STR) concentrations were investigated. The response peak current of STP/MMCM/MGCE showed a good linear relationship with STR concentration, and there were two linear ranges on the STP/MMCM/MGCE surface.

: Streptomycin purchased from MedChemExpress. Usage Cited in: Food Chem. 2023 Mar 1:403:134399. [Abstract]; Selectivity assessment of the aptasensor was conducted. The DPV peak current changed in the presence of the same concentration of structural analogues of Streptomycin (S) (0.01 mg/mL), such as kanamycin (K), gentamicin (G), and tobramycin (T). The change of peak current was not particularly obvious when the concentration of the interfering substance (1 mg/mL) was 100 times higher than that of streptomycin (S).

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Aminoglycoside

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	CC₅₀	> 1000 μg/mL Compound: Streptomycin	Cytotoxicity against mouse J774A1 cells after 24 to 72 hrs by MTT assay Cytotoxicity against mouse J774A1 cells after 24 to 72 hrs by MTT assay	[PMID: 20934344]
Sf21	IC₅₀	> 1000 μM Compound: Streptomycin	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Sf21	IC₅₀	> 1000 μM Compound: Streptomycin	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
THP-1	IC₅₀	> 258 μM Compound: Streptomycin	Cytotoxicity against human THP1 cells assessed as growth inhibition after 24 to 48 hrs by MTT assay Cytotoxicity against human THP1 cells assessed as growth inhibition after 24 to 48 hrs by MTT assay	[PMID: 29529504]
Vero	IC₅₀	> 100 μM Compound: streptomycin	Cytotoxicity against Vero cells Cytotoxicity against Vero cells	[PMID: 17562368]
Vero	IC₅₀	> 100 μg/mL Compound: SM	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay	[PMID: 24087924]
Vero	IC₅₀	> 120 μg/mL Compound: streptomycin	Cytotoxicity against Vero cells after 48 hrs by XTT method Cytotoxicity against Vero cells after 48 hrs by XTT method	[PMID: 17888665]
Vero	IC₅₀	> 50 μg/mL Compound: Streptomycin	Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 24044875]

In Vitro

Streptomycin is a potent inhibitor of the hypotonicity-induced Ca²⁺entry and Cl channel activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

581.57

Formula

C₂₁H₃₉N₇O₁₂

CAS No.

57-92-1

Appearance

Solid

Color

White to off-white

SMILES

N=C(N)N[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)O)NC(N)=N)O)[C@H]1O[C@H](O[C@H]([C@]2(O)C=O)C)[C@@H]2O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (214.94 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7195 mL	8.5974 mL	17.1948 mL
5 mM	0.3439 mL	1.7195 mL	3.4390 mL
10 mM	0.1719 mL	0.8597 mL	1.7195 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (280 KB) SDS (393 KB)

COA (258 KB) HNMR (308 KB) RP-HPLC (248 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. J DAVIES, et al. STREPTOMYCIN, SUPPRESSION, AND THE CODE. Proc Natl Acad Sci U S A. 1964 May;51(5):883-90. [Content Brief]

[2]. Deisy M G C Rocha, et al. The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem. Genes (Basel). 2021 Dec 17;12(12):2003. [Content Brief]

[3]. Mandeep Singh, et al. Streptomycin sulphate loaded solid lipid nanoparticles show enhanced uptake in macrophage, lower MIC in Mycobacterium and improved oral bioavailability. Eur J Pharm Biopharm. 2021 Mar;160:100-124. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.7195 mL	8.5974 mL	17.1948 mL	42.9871 mL
	5 mM	0.3439 mL	1.7195 mL	3.4390 mL	8.5974 mL
	10 mM	0.1719 mL	0.8597 mL	1.7195 mL	4.2987 mL
	15 mM	0.1146 mL	0.5732 mL	1.1463 mL	2.8658 mL
	20 mM	0.0860 mL	0.4299 mL	0.8597 mL	2.1494 mL
	25 mM	0.0688 mL	0.3439 mL	0.6878 mL	1.7195 mL
	30 mM	0.0573 mL	0.2866 mL	0.5732 mL	1.4329 mL
	40 mM	0.0430 mL	0.2149 mL	0.4299 mL	1.0747 mL
	50 mM	0.0344 mL	0.1719 mL	0.3439 mL	0.8597 mL
	60 mM	0.0287 mL	0.1433 mL	0.2866 mL	0.7165 mL
	80 mM	0.0215 mL	0.1075 mL	0.2149 mL	0.5373 mL
	100 mM	0.0172 mL	0.0860 mL	0.1719 mL	0.4299 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Streptomycin Related Classifications

Neurological Disease Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Streptomycin (Synonyms: Agrept; Agrimycin; Streptomycin A)

Customer Review

Other Forms of Streptomycin:

Streptomycin Related Antibodies

46 Publications Citing Use of MCE Streptomycin

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Streptomycin Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Streptomycin Related Classifications

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