Penicillin G
Based on 25 publication(s) in Google Scholar
Penicillin G is a potent penicillinantibiotic. Penicillin G can be used for bacterial infection. Penicillin G has potent activity against all Gram-positive bacteria and Gram-negative cocci.
For research use only. We do not sell to patients.
- CAS No.: 61-33-6
- Formula: C16H18N2O4S
- Molecular Weight:334.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Penicillin G
More- Cancer Res. 2023 Apr 4;83(7):1048-1061. [Abstract]
- Adv Sci (Weinh). 2025 Jul 17:e03098. [Abstract]
- Theranostics. 2022 Jan 1;12(3):1187-1203. [Abstract]
- J Control Release. 2024 Oct 26:S0168-3659(24)00725-9. [Abstract]
- EBioMedicine. 2022 Apr;78:103943. [Abstract]
- J Neuroinflammation. 2025 Aug 26;22(1):207. [Abstract]
- Genes Dis. 2025 Apr 9;13(2):101625. [Abstract]
- NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111. [Abstract]
- Phytomedicine. 2025 Dec:149:157553. [Abstract]
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
- Eur J Med Chem. 2024 Dec 5:279:116842. [Abstract]
- Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]
- Int Immunopharmacol. 2024 Feb 15:128:111524. [Abstract]
- Neuropharmacology. 2026 Jul 1:292:110950. [Abstract]
- Cancers (Basel). 2022 Sep 28;14(19):4740. [Abstract]
- Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702. [Abstract]
- Microbiol Spectr. 2025 Oct 15:e0122125. [Abstract]
- Anal Bioanal Chem. 2025 Jan;417(3):615-625. [Abstract]
- BMC Complement Med Ther. 2023 Jul 1;23(1):218. [Abstract]
- BMC Cancer. 2023 Mar 14;23(1):241. [Abstract]
- Front Physiol. 2020 Dec 23:11:605982. [Abstract]
- Water. 2025 Jun 6.
- Oncol Lett. 2025 Jun 10;30(2):387. [Abstract]
- In Vitro Cell Dev Biol Anim. 2024 Oct;60(9):1046-1057. [Abstract]
- Eur Rev Med Pharmacol Sci. 2019 Sep;23(17):7419-7429. [Abstract]
All Antibiotic Isoforms
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Biological Activity
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β-lactam |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
89.4 μM
Compound: Penicillin G
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Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
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[PMID: 23344796] |
| HepG2 | IC50 |
>10000 μM
Compound: PNC
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
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[PMID: 24953953] |
| HepG2 | IC50 |
>10000 μM
Compound: PNC
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Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
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[PMID: 25593095] |
| Macrophage | CC50 |
228.9 μM
Compound: Penicillin G
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Cytotoxicity against human macrophages after 24 hrs by MTT assay
Cytotoxicity against human macrophages after 24 hrs by MTT assay
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[PMID: 24561667] |
| Macrophage | IC50 |
185.72 μM
Compound: Penicillin G
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Cytotoxicity against human macrophages assessed as cell viability after 24 hrs by MTT assay
Cytotoxicity against human macrophages assessed as cell viability after 24 hrs by MTT assay
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[PMID: 25306465] |
Penicillin G (16-128 μg/mL, 0-20 h) is used in combination with promethazine (32 μg/mL) to inhibit the growth and viability of E. coli[2].
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 61-33-6
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Molecular Weight 334.39
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Formula C16H18N2O4S
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SMILES
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(CC3=CC=CC=C3)=O)N1C2=O)O
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Synonyms
Benzylpenicillin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (25)
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Journal Impact Factor
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Most Recent
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Cancer Res
HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to support liver cancer progression. [Abstract]2023 Apr 4;83(7):1048-1061. PMID: 36745032 -
Adv Sci (Weinh)
2025 Jul 17:e03098. PMID: 40673882 -
Theranostics
Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents. [Abstract]2022 Jan 1;12(3):1187-1203. PMID: 35154482 -
J Control Release
2024 Oct 26:S0168-3659(24)00725-9. PMID: 39490420 -
EBioMedicine
A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria. [Abstract]2022 Apr;78:103943. PMID: 35306337 -
J Neuroinflammation
Disrupted betaine metabolism drives Th17 cell differentiation, mediating methamphetamine-induced depressive behaviors in male mice. [Abstract]2025 Aug 26;22(1):207. PMID: 40859333 -
Genes Dis
Low expression of OXCT1 promote colorectal cancer liver metastasis by upregulating CDK8 and β-catenin via H3 acetylation. [Abstract]2025 Apr 9;13(2):101625. PMID: 41492470 -
NPJ Biofilms Microbiomes
Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function. [Abstract]2024 Oct 28;10(1):111. PMID: 39468065 -
Phytomedicine
Liquiritigenin attenuates thrombosis by inhibiting P2Y12R-mediated Src/PLCγ2 signaling and cytoplasmic Ca2+ mobilization in platelets. [Abstract]2025 Dec:149:157553. PMID: 41273866 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299 -
Eur J Med Chem
2024 Dec 5:279:116842. PMID: 39260319 -
Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2025 Dec 21:170:116080. PMID: 41429063 -
Int Immunopharmacol
Hypidone hydrochloride (YL-0919) protects mice from meningitis via Sigma1R-STAT1-NLRP3-GSDMD pathway. [Abstract]2024 Feb 15:128:111524. PMID: 38232537 -
Neuropharmacology
Novel mechanism of hypidone hydrochloride (YL-0919) in Parkinson's disease: inhibiting neuronal ferroptosis by targeting the Sigma1R-PI3K-AKT-ACSL4 axis. [Abstract]2026 Jul 1:292:110950. PMID: 41887568 -
Cancers (Basel)
LncRNA SNHG1 Facilitates Tumor Proliferation and Represses Apoptosis by Regulating PPARγ Ubiquitination in Bladder Cancer. [Abstract]2022 Sep 28;14(19):4740. PMID: 36230661 -
Appl Microbiol Biotechnol
2022 Apr;106(7):2689-2702. PMID: 35338386 -
Microbiol Spectr
Montelukast treats Streptococcus pneumoniae-induced sepsis via antibacterial and anti-inflammatory activities. [Abstract]2025 Oct 15:e0122125. PMID: 41090944 -
Anal Bioanal Chem
2025 Jan;417(3):615-625. PMID: 39613988 -
BMC Complement Med Ther
Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis. [Abstract]2023 Jul 1;23(1):218. PMID: 37393274 -
BMC Cancer
Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma. [Abstract]2023 Mar 14;23(1):241. PMID: 36918801 -
Front Physiol
Oral Administration of Penicillin or Streptomycin May Alter Serum Serotonin Level and Intestinal Motility via Different Mechanisms. [Abstract]2020 Dec 23:11:605982. PMID: 33424630 -
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Oncol Lett
Propionate metabolism-related genes demonstrate the potential to serve as prognostic and immunotherapeutic markers in osteosarcoma. [Abstract]2025 Jun 10;30(2):387. PMID: 40535100 -
In Vitro Cell Dev Biol Anim
Liraglutide ameliorates high glucose-induced vascular endothelial injury through TRIB3/NF-κB signaling pathway. [Abstract]2024 Oct;60(9):1046-1057. PMID: 39039329 -
Eur Rev Med Pharmacol Sci
Novel long non-coding RNA LBX2-AS1 indicates poor prognosis and promotes cell proliferation and metastasis through Notch signaling in non-small cell lung cancer. [Abstract]2019 Sep;23(17):7419-7429. PMID: 31539129
Purity & Documentation
References
[1]. Li D, et al. Determination of penicillin G and its degradation products in a penicillin production wastewater treatment plant and the receiving river. Water Res. 2008 Jan;42(1-2):307-17. [Content Brief]
[2]. Lehtinen J, et al. Promethazine renders Escherichia coli susceptible to penicillin G: real-time measurement of bacterial susceptibility by fluoro-luminometry. Int J Antimicrob Agents. 2007 Jul;30(1):44-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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