Penicillin G potassium
Based on 25 publication(s) in Google Scholar
Penicillin G potassium is a fast-acting penicillin family antibiotic. Penicillin G potassium can be used for the research of bacterial infections that affect the blood, heart, lungs, joints, and genital areas.
For research use only. We do not sell to patients.
- Purity: 99.74%
- CAS No.: 113-98-4
- Formula: C16H17KN2O4S
- Molecular Weight:372.48
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Storage:
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Penicillin G potassium
More- Cancer Res. 2023 Apr 4;83(7):1048-1061. [Abstract]
- Theranostics. 2022 Jan 1;12(3):1187-1203. [Abstract]
- Genes Dis. 2025 Apr 9;13(2):101625. [Abstract]
- Adv Sci (Weinh). 2025 Jul 17:e03098. [Abstract]
- J Control Release. 2024 Oct 26:S0168-3659(24)00725-9. [Abstract]
- J Neuroinflammation. 2025 Aug 26;22(1):207. [Abstract]
- NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111. [Abstract]
- Phytomedicine. 2025 Dec:149:157553. [Abstract]
- EBioMedicine. 2022 Apr;78:103943. [Abstract]
- Eur J Med Chem. 2024 Dec 5:279:116842. [Abstract]
- Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]
- Int Immunopharmacol. 2024 Feb 15:128:111524. [Abstract]
- Cancers (Basel). 2022 Sep 28;14(19):4740. [Abstract]
- Neuropharmacology. 2026 Jul 1:292:110950. [Abstract]
- Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702. [Abstract]
- BMC Complement Med Ther. 2023 Jul 1;23(1):218. [Abstract]
- Front Physiol. 2020 Dec 23:11:605982. [Abstract]
- Microbiol Spectr. 2025 Oct 15:e0122125. [Abstract]
- Anal Bioanal Chem. 2025 Jan;417(3):615-625. [Abstract]
- BMC Cancer. 2023 Mar 14;23(1):241. [Abstract]
- Water. 2025 Jun 6.
- Oncol Lett. 2025 Jun 10;30(2):387. [Abstract]
- In Vitro Cell Dev Biol Anim. 2024 Oct;60(9):1046-1057. [Abstract]
- Eur Rev Med Pharmacol Sci. 2019 Sep;23(17):7419-7429. [Abstract]
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
All Antibiotic Isoforms
More
Biological Activity
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β-lactam |
Penicillin G (16-128 μg/mL, 0-20 h) is used in combination with promethazine (32 μg/mL) to inhibit the growth and viability of E. coli[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 113-98-4
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Appearance Solid
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Molecular Weight 372.48
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Formula C16H17KN2O4S
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Color White to off-white
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SMILES
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(CC3=CC=CC=C3)=O)N1C2=O)O[K]
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Synonyms
Benzylpenicillin potassium
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Initial Source
Penicillium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (25)
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Journal Impact Factor
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Most Recent
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Cancer Res
HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to support liver cancer progression. [Abstract]2023 Apr 4;83(7):1048-1061. PMID: 36745032 -
Theranostics
Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents. [Abstract]2022 Jan 1;12(3):1187-1203. PMID: 35154482 -
Genes Dis
Low expression of OXCT1 promote colorectal cancer liver metastasis by upregulating CDK8 and β-catenin via H3 acetylation. [Abstract]2025 Apr 9;13(2):101625. PMID: 41492470 -
Adv Sci (Weinh)
2025 Jul 17:e03098. PMID: 40673882 -
J Control Release
2024 Oct 26:S0168-3659(24)00725-9. PMID: 39490420 -
J Neuroinflammation
Disrupted betaine metabolism drives Th17 cell differentiation, mediating methamphetamine-induced depressive behaviors in male mice. [Abstract]2025 Aug 26;22(1):207. PMID: 40859333 -
NPJ Biofilms Microbiomes
Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function. [Abstract]2024 Oct 28;10(1):111. PMID: 39468065 -
Phytomedicine
Liquiritigenin attenuates thrombosis by inhibiting P2Y12R-mediated Src/PLCγ2 signaling and cytoplasmic Ca2+ mobilization in platelets. [Abstract]2025 Dec:149:157553. PMID: 41273866 -
EBioMedicine
A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria. [Abstract]2022 Apr;78:103943. PMID: 35306337 -
Eur J Med Chem
2024 Dec 5:279:116842. PMID: 39260319 -
Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2025 Dec 21:170:116080. PMID: 41429063 -
Int Immunopharmacol
Hypidone hydrochloride (YL-0919) protects mice from meningitis via Sigma1R-STAT1-NLRP3-GSDMD pathway. [Abstract]2024 Feb 15:128:111524. PMID: 38232537 -
Cancers (Basel)
LncRNA SNHG1 Facilitates Tumor Proliferation and Represses Apoptosis by Regulating PPARγ Ubiquitination in Bladder Cancer. [Abstract]2022 Sep 28;14(19):4740. PMID: 36230661 -
Neuropharmacology
Novel mechanism of hypidone hydrochloride (YL-0919) in Parkinson's disease: inhibiting neuronal ferroptosis by targeting the Sigma1R-PI3K-AKT-ACSL4 axis. [Abstract]2026 Jul 1:292:110950. PMID: 41887568 -
Appl Microbiol Biotechnol
2022 Apr;106(7):2689-2702. PMID: 35338386 -
BMC Complement Med Ther
Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis. [Abstract]2023 Jul 1;23(1):218. PMID: 37393274 -
Front Physiol
Oral Administration of Penicillin or Streptomycin May Alter Serum Serotonin Level and Intestinal Motility via Different Mechanisms. [Abstract]2020 Dec 23:11:605982. PMID: 33424630 -
Microbiol Spectr
Montelukast treats Streptococcus pneumoniae-induced sepsis via antibacterial and anti-inflammatory activities. [Abstract]2025 Oct 15:e0122125. PMID: 41090944 -
Anal Bioanal Chem
2025 Jan;417(3):615-625. PMID: 39613988 -
BMC Cancer
Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma. [Abstract]2023 Mar 14;23(1):241. PMID: 36918801 -
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Oncol Lett
Propionate metabolism-related genes demonstrate the potential to serve as prognostic and immunotherapeutic markers in osteosarcoma. [Abstract]2025 Jun 10;30(2):387. PMID: 40535100 -
In Vitro Cell Dev Biol Anim
Liraglutide ameliorates high glucose-induced vascular endothelial injury through TRIB3/NF-κB signaling pathway. [Abstract]2024 Oct;60(9):1046-1057. PMID: 39039329 -
Eur Rev Med Pharmacol Sci
Novel long non-coding RNA LBX2-AS1 indicates poor prognosis and promotes cell proliferation and metastasis through Notch signaling in non-small cell lung cancer. [Abstract]2019 Sep;23(17):7419-7429. PMID: 31539129 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
Solvent & Solubility
H2O : 100 mg/mL (268.47 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (268.47 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Roussel AJ, et al. Evaluation of the effects of penicillin G potassium and potassium chloride on the motility of the large intestine in horses. Am J Vet Res. 2003 Nov;64(11):1360-3. [Content Brief]
[2]. Byra C, et al. Decreased mortality of weaned pigs with Streptococcus suis with the use of in-water potassium penicillin G. Can Vet J. 2011 Mar;52(3):272-6. [Content Brief]
[3]. Lehtinen J, et al. Promethazine renders Escherichia coli susceptible to penicillin G: real-time measurement of bacterial susceptibility by fluoro-luminometry. Int J Antimicrob Agents. 2007 Jul;30(1):44-51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 2.6847 mL | 13.4235 mL | 26.8471 mL | 67.1177 mL |
| 5 mM | 0.5369 mL | 2.6847 mL | 5.3694 mL | 13.4235 mL | |
| 10 mM | 0.2685 mL | 1.3424 mL | 2.6847 mL | 6.7118 mL | |
| 15 mM | 0.1790 mL | 0.8949 mL | 1.7898 mL | 4.4745 mL | |
| 20 mM | 0.1342 mL | 0.6712 mL | 1.3424 mL | 3.3559 mL | |
| 25 mM | 0.1074 mL | 0.5369 mL | 1.0739 mL | 2.6847 mL | |
| 30 mM | 0.0895 mL | 0.4475 mL | 0.8949 mL | 2.2373 mL | |
| 40 mM | 0.0671 mL | 0.3356 mL | 0.6712 mL | 1.6779 mL | |
| 50 mM | 0.0537 mL | 0.2685 mL | 0.5369 mL | 1.3424 mL | |
| 60 mM | 0.0447 mL | 0.2237 mL | 0.4475 mL | 1.1186 mL | |
| 80 mM | 0.0336 mL | 0.1678 mL | 0.3356 mL | 0.8390 mL | |
| 100 mM | 0.0268 mL | 0.1342 mL | 0.2685 mL | 0.6712 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Penicillin G potassium Related Classifications
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