1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Sulfamethazine

Sulfamethazine (Synonyms: Sulfadimidine; Sulfadimerazine)

Cat. No.: HY-B0035 Purity: 99.78%
Handling Instructions

Sulfamethazine (Sulfadimidine) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine in animal product is set at 100 µg/kg.

For research use only. We do not sell to patients.

Sulfamethazine Chemical Structure

Sulfamethazine Chemical Structure

CAS No. : 57-68-1

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10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Sulfamethazine:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sulfamethazine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sulfamethazine (Sulfadimidine) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine in animal product is set at 100 µg/kg[1][2].

IC50 & Target

Bacterial[1]

In Vivo

Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 19 healthy female pigs (6-week-old, 4.5-6.2 kg)[1]
Dosage: 80 mg/kg
Administration: Intravenous injection (Pharmacokinetic study)
Result: The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.
Molecular Weight

278.33

Formula

C12H14N4O2S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (359.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5929 mL 17.9643 mL 35.9286 mL
5 mM 0.7186 mL 3.5929 mL 7.1857 mL
10 mM 0.3593 mL 1.7964 mL 3.5929 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.78%

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Product Name:
Sulfamethazine
Cat. No.:
HY-B0035
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