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Cat. No.: HY-B0035B

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Sulfamethazine 100 µg/mL in acetonitrile

Name: Sulfamethazine 100 µg/mL in acetonitrile
Brand: MedChemExpress
SKU: HY-B0035B
Availability: PreOrder

(Synonyms: Sulfadimidine 100 µg/mL in acetonitrile; Sulfadimerazine 100 µg/mL in acetonitrile)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Sulfamethazine (Sulfadimidine) 100 µg/mL in acetonitrile is a brain-penetrant sulfonamide antibiotic. Sulfamethazine 100 µg/mL in acetonitrile inhibits bacterial growth by blocking the synthesis of folic acid. Sulfamethazine 100 µg/mL in acetonitrile can be used for research on bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 57-68-1
Formula: C₁₂H₁₄N₄O₂S
Molecular Weight:278.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Sulfamethazine 100 µg/mL in acetonitrile Chemical Structure

CAS No.: 57-68-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Parmacokinetics
- In Vivo
Chemical Information
Publications (3)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Antibiotic Isoforms :

Parmacokinetics

Species	Dose	Route	V_d	AUC_0-∞
Pig^[3]	80 mg/kg	i.v.	0.77 L/kg	1485 mg/h/L

In Vivo

Sulfamethazine (0.3 g/kg; i.m.; single dose) 100 µg/mL in acetonitrile demonstrates restricted passage across the blood-brain barrier in adult pregnant and non-pregnant Wistar rats, with brain levels consistently reaching 30-37% of corresponding blood levels^[1].
Sulfamethazine (80 mg/kg; i.v.; single dose) 100 µg/mL in acetonitrile treatment significantly reduced α, β and AUC_0-∞, and significantly increased t_1/2α, V_d and CIB, with an absolute bioavailability of 1.01^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (adult female, pregnant and non-pregnant)^[2]
Dosage:

0.3 g/kg
Administration:

i.m.; single dose
Result:

Measured blood sulfamethazine level of 17.27 mg/100 mL and brain level of 5.71 mg/100 mL (33% of blood level) at 60 minutes in gestational day 10 pregnant rats receiving carbadox.
Reached peak blood sulfamethazine level of 22.23 mg/100 mL and brain level of 8.30 mg/100 mL (37% of blood level) at 120 minutes in gestational day 10 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 15.55 mg/100 mL and brain level of 5.11 mg/100 mL (32% of blood level) at 240 minutes in gestational day 10 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 23.44 mg/100 mL and brain level of 7.35 mg/100 mL (31% of blood level) at 60 minutes in gestational day 20 pregnant rats receiving carbadox.
Reached peak blood sulfamethazine level of 31.51 mg/100 mL and brain level of 11.11 mg/100 mL (35% of blood level) at 120 minutes in gestational day 20 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 25.20 mg/100 mL and brain level of 8.30 mg/100 mL (32% of blood level) at 240 minutes in gestational day 20 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 17.24 mg/100 mL and brain level of 5.15 mg/100 mL (30% of blood level) at 60 minutes in gestational day 10 pregnant rats not receiving carbadox.
Reached peak blood sulfamethazine level of 22.75 mg/100 mL and brain level of 8.25 mg/100 mL (36% of blood level) at 120 minutes in gestational day 10 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 15.80 mg/100 mL and brain level of 5.15 mg/100 mL (32% of blood level) at 240 minutes in gestational day 10 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 23.78 mg/100 mL and brain level of 8.05 mg/100 mL (33% of blood level) at 60 minutes in gestational day 20 pregnant rats not receiving carbadox.
Reached peak blood sulfamethazine level of 30.72 mg/100 mL and brain level of 10.83 mg/100 mL (35% of blood level) at 120 minutes in gestational day 20 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 25.68 mg/100 mL and brain level of 8.77 mg/100 mL (34% of blood level) at 240 minutes in gestational day 20 pregnant rats not receiving carbadox.
Observed slightly higher blood sulfamethazine levels in pregnant rats than non-pregnant counterparts, and higher levels in 20-day pregnant rats than 10-day pregnant rats.
Detected no significant difference in sulfamethazine levels in blood and brain between rats receiving carbadox and those that did not.

Chemical Information

CAS No. 57-68-1
Molecular Weight 278.33
Formula C₁₂H₁₄N₄O₂S
SMILES

O=S(C1=CC=C(N)C=C1)(NC2=NC(C)=CC(C)=N2)=O
Synonyms

Sulfadimidine 100 µg/mL in acetonitrile; Sulfadimerazine 100 µg/mL in acetonitrile
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Journal Impact Factor

ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Chemosphere

Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]

2019 Jun:225:378-387. PMID: 30884299

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Siddique AB, et al. Effect of Carbadox on the Passage of Sulfamethazine through the Blood-Brain Barrier in Rat. Acta Vet. Brno. 1979 Jan;48(1):79-84.

[2]. VAN Poucke LSG, et al. Pharmacokinetics and Tissue Residues of Sulfathiazole and Sulfamethazine in Pigs. J Food Prot. 1994;57(9):796-801. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Sulfamethazine 100 µg/mL in acetonitrile

3 Cited Publications

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Biological Activity
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Publications (3)
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References

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Sulfamethazine 100 µg/mL in acetonitrile

Publications Citing Use of MedChemExpress (MCE) Sulfamethazine 100 µg/mL in acetonitrile

All Antibiotic Isoforms