2. Anti-infection
  3. Antibiotic Bacterial
  4. Sulfamethazine 100 µg/mL in acetonitrile

Sulfamethazine 100 µg/mL in acetonitrile  (Synonyms: Sulfadimidine 100 µg/mL in acetonitrile; Sulfadimerazine 100 µg/mL in acetonitrile)

製品番号: HY-B0035B
取扱説明書 Technical Support

Sulfamethazine (Sulfadimidine) 100 µg/mL in acetonitrile is a brain-penetrant sulfonamide antibiotic. Sulfamethazine 100 µg/mL in acetonitrile inhibits bacterial growth by blocking the synthesis of folic acid. Sulfamethazine 100 µg/mL in acetonitrile can be used for research on bacterial infections.

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Sulfamethazine 100 µg/mL in acetonitrile

Sulfamethazine 100 µg/mL in acetonitrile 構造式

CAS 番号 : 57-68-1

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Sulfamethazine 100 µg/mL in acetonitrile 関連抗体

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製品説明

Sulfamethazine (Sulfadimidine) 100 µg/mL in acetonitrile is a brain-penetrant sulfonamide antibiotic. Sulfamethazine 100 µg/mL in acetonitrile inhibits bacterial growth by blocking the synthesis of folic acid. Sulfamethazine 100 µg/mL in acetonitrile can be used for research on bacterial infections[1][2].

Parmacokinetics
Species Dose Route Vd AUC0-∞
Pig[3] 80 mg/kg i.v. 0.77 L/kg 1485 mg/h/L
体内実験

Sulfamethazine (0.3 g/kg; i.m.; single dose) demonstrates restricted passage across the blood-brain barrier in adult pregnant and non-pregnant Wistar rats, with brain levels consistently reaching 30-37% of corresponding blood levels[1].
Sulfamethazine (80 mg/kg; i.v.; single dose) treatment significantly reduced α, β and AUC0-∞, and significantly increased t1/2α, Vd and CIB, with an absolute bioavailability of 1.01[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (adult female, pregnant and non-pregnant)[2]
Dosage: 0.3 g/kg
Administration: i.m.; single dose
Result: Measured blood sulfamethazine level of 17.27 mg/100 mL and brain level of 5.71 mg/100 mL (33% of blood level) at 60 minutes in gestational day 10 pregnant rats receiving carbadox.
Reached peak blood sulfamethazine level of 22.23 mg/100 mL and brain level of 8.30 mg/100 mL (37% of blood level) at 120 minutes in gestational day 10 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 15.55 mg/100 mL and brain level of 5.11 mg/100 mL (32% of blood level) at 240 minutes in gestational day 10 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 23.44 mg/100 mL and brain level of 7.35 mg/100 mL (31% of blood level) at 60 minutes in gestational day 20 pregnant rats receiving carbadox.
Reached peak blood sulfamethazine level of 31.51 mg/100 mL and brain level of 11.11 mg/100 mL (35% of blood level) at 120 minutes in gestational day 20 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 25.20 mg/100 mL and brain level of 8.30 mg/100 mL (32% of blood level) at 240 minutes in gestational day 20 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 17.24 mg/100 mL and brain level of 5.15 mg/100 mL (30% of blood level) at 60 minutes in gestational day 10 pregnant rats not receiving carbadox.
Reached peak blood sulfamethazine level of 22.75 mg/100 mL and brain level of 8.25 mg/100 mL (36% of blood level) at 120 minutes in gestational day 10 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 15.80 mg/100 mL and brain level of 5.15 mg/100 mL (32% of blood level) at 240 minutes in gestational day 10 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 23.78 mg/100 mL and brain level of 8.05 mg/100 mL (33% of blood level) at 60 minutes in gestational day 20 pregnant rats not receiving carbadox.
Reached peak blood sulfamethazine level of 30.72 mg/100 mL and brain level of 10.83 mg/100 mL (35% of blood level) at 120 minutes in gestational day 20 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 25.68 mg/100 mL and brain level of 8.77 mg/100 mL (34% of blood level) at 240 minutes in gestational day 20 pregnant rats not receiving carbadox.
Observed slightly higher blood sulfamethazine levels in pregnant rats than non-pregnant counterparts, and higher levels in 20-day pregnant rats than 10-day pregnant rats.
Detected no significant difference in sulfamethazine levels in blood and brain between rats receiving carbadox and those that did not.
分子量

278.33

分子式

C12H14N4O2S
CAS 番号
SMILES

O=S(C1=CC=C(N)C=C1)(NC2=NC(C)=CC(C)=N2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献
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Sulfamethazine 100 µg/mL in acetonitrile Related Classifications

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Keywords:

Sulfamethazine 100 µg/mL in acetonitrile57-68-1Sulfadimidine 100 µg/mL in acetonitrile Sulfadimerazine 100 µg/mL in acetonitrileAntibioticBacterialthyroid follicular hyperplasiaAmes testthyroid follicular hypertrophychromosomal aberration testthyroid peroxidaseunscheduled DNA synthesis testrodent tumorthyroid cancer cellthyroxinepituitary thyroid-stimulating hormoneInhibitorinhibitorinhibit

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Sulfamethazine 100 µg/mL in acetonitrile
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