2. Anti-infection
  3. Antibiotic Bacterial
  4. Sulfamethazine 100 µg/mL in acetonitrile

Sulfamethazine 100 µg/mL in acetonitrile  (Synonyms: Sulfadimidine 100 µg/mL in acetonitrile; Sulfadimerazine 100 µg/mL in acetonitrile)

Cat. No.: HY-B0035B
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Sulfamethazine (Sulfadimidine) 100 µg/mL in acetonitrile is a brain-penetrant sulfonamide antibiotic. Sulfamethazine 100 µg/mL in acetonitrile inhibits bacterial growth by blocking the synthesis of folic acid. Sulfamethazine 100 µg/mL in acetonitrile can be used for research on bacterial infections.

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Sulfamethazine 100 µg/mL in acetonitrile

Sulfamethazine 100 µg/mL in acetonitrile Chemical Structure

CAS No. : 57-68-1

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Description

Sulfamethazine (Sulfadimidine) 100 µg/mL in acetonitrile is a brain-penetrant sulfonamide antibiotic. Sulfamethazine 100 µg/mL in acetonitrile inhibits bacterial growth by blocking the synthesis of folic acid. Sulfamethazine 100 µg/mL in acetonitrile can be used for research on bacterial infections[1][2].

Parmacokinetics
Species Dose Route Vd AUC0-∞
Pig[3] 80 mg/kg i.v. 0.77 L/kg 1485 mg/h/L
In Vivo

Sulfamethazine (0.3 g/kg; i.m.; single dose) demonstrates restricted passage across the blood-brain barrier in adult pregnant and non-pregnant Wistar rats, with brain levels consistently reaching 30-37% of corresponding blood levels[1].
Sulfamethazine (80 mg/kg; i.v.; single dose) treatment significantly reduced α, β and AUC0-∞, and significantly increased t1/2α, Vd and CIB, with an absolute bioavailability of 1.01[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (adult female, pregnant and non-pregnant)[2]
Dosage: 0.3 g/kg
Administration: i.m.; single dose
Result: Measured blood sulfamethazine level of 17.27 mg/100 mL and brain level of 5.71 mg/100 mL (33% of blood level) at 60 minutes in gestational day 10 pregnant rats receiving carbadox.
Reached peak blood sulfamethazine level of 22.23 mg/100 mL and brain level of 8.30 mg/100 mL (37% of blood level) at 120 minutes in gestational day 10 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 15.55 mg/100 mL and brain level of 5.11 mg/100 mL (32% of blood level) at 240 minutes in gestational day 10 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 23.44 mg/100 mL and brain level of 7.35 mg/100 mL (31% of blood level) at 60 minutes in gestational day 20 pregnant rats receiving carbadox.
Reached peak blood sulfamethazine level of 31.51 mg/100 mL and brain level of 11.11 mg/100 mL (35% of blood level) at 120 minutes in gestational day 20 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 25.20 mg/100 mL and brain level of 8.30 mg/100 mL (32% of blood level) at 240 minutes in gestational day 20 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 17.24 mg/100 mL and brain level of 5.15 mg/100 mL (30% of blood level) at 60 minutes in gestational day 10 pregnant rats not receiving carbadox.
Reached peak blood sulfamethazine level of 22.75 mg/100 mL and brain level of 8.25 mg/100 mL (36% of blood level) at 120 minutes in gestational day 10 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 15.80 mg/100 mL and brain level of 5.15 mg/100 mL (32% of blood level) at 240 minutes in gestational day 10 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 23.78 mg/100 mL and brain level of 8.05 mg/100 mL (33% of blood level) at 60 minutes in gestational day 20 pregnant rats not receiving carbadox.
Reached peak blood sulfamethazine level of 30.72 mg/100 mL and brain level of 10.83 mg/100 mL (35% of blood level) at 120 minutes in gestational day 20 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 25.68 mg/100 mL and brain level of 8.77 mg/100 mL (34% of blood level) at 240 minutes in gestational day 20 pregnant rats not receiving carbadox.
Observed slightly higher blood sulfamethazine levels in pregnant rats than non-pregnant counterparts, and higher levels in 20-day pregnant rats than 10-day pregnant rats.
Detected no significant difference in sulfamethazine levels in blood and brain between rats receiving carbadox and those that did not.
Molecular Weight

278.33

Formula

C12H14N4O2S
CAS No.
SMILES

O=S(C1=CC=C(N)C=C1)(NC2=NC(C)=CC(C)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sulfamethazine 100 µg/mL in acetonitrile Related Classifications

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Keywords:

Sulfamethazine 100 µg/mL in acetonitrile57-68-1Sulfadimidine 100 µg/mL in acetonitrile Sulfadimerazine 100 µg/mL in acetonitrileAntibioticBacterialthyroid follicular hyperplasiaAmes testthyroid follicular hypertrophychromosomal aberration testthyroid peroxidaseunscheduled DNA synthesis testrodent tumorthyroid cancer cellthyroxinepituitary thyroid-stimulating hormoneInhibitorinhibitorinhibit

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