2. Anti-infection
  3. Bacterial Antibiotic
  4. Sulfamethoxazole

Sulfamethoxazole  (Synonyms: Ro 4-2130)

Cat. No.: HY-B0322 Purity: 99.91%
COA Handling Instructions

Sulfamethoxazole (Ro 4-2130) is a sulfonamide bacteriostatic antibiotic, used for bacterial infections. Sulfonamides is a competitive antagonists of para-aminobenzoic acid (PABA).

For research use only. We do not sell to patients.

Sulfamethoxazole Chemical Structure

Sulfamethoxazole Chemical Structure

CAS No. : 723-46-6

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Solution
10 mM * 1 mL in DMSO USD 87 In-stock
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10 mM * 1 mL
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Solid
100 mg USD 79 In-stock
500 mg USD 119 In-stock
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Based on 8 publication(s) in Google Scholar

Other Forms of Sulfamethoxazole:

Sulfamethoxazole Related Antibodies

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Description

Sulfamethoxazole (Ro 4-2130) is a sulfonamide bacteriostatic antibiotic, used for bacterial infections. Sulfonamides is a competitive antagonists of para-aminobenzoic acid (PABA)[1].

IC50 & Target

Antibacterial
In Vitro

Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis.? The effects seen are usually bacteriostatic in nature. Folic acid is not synthesized in humans, but is instead a dietary requirement. This allows for the selective toxicity to bacterial cells (or any cell dependent on synthesizing folic acid) over human cells. Bacterial resistance to sulfamethoxazole is caused by mutations in the enzymes involved in folic acid synthesis that prevent the drug from binding to it.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfamethoxazole Related Antibodies
Clinical Trial
Molecular Weight

253.28

Appearance

Solid

Formula

C10H11N3O3S
CAS No.
SMILES

O=S(C1=CC=C(N)C=C1)(NC2=NOC(C)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (394.82 mM)

H2O : 0.1 mg/mL (0.39 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9482 mL 19.7410 mL 39.4820 mL
5 mM 0.7896 mL 3.9482 mL 7.8964 mL
10 mM 0.3948 mL 1.9741 mL 3.9482 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.87 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Sulfamethoxazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Sulfamethoxazole723-46-6Ro 4-2130BacterialAntibioticInhibitorinhibitorinhibit

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