Sulfamethoxazole 1000 µg/mL in methanol (Synonyms: Ro 4-2130 1000 µg/mL in methanol)

Name: Sulfamethoxazole 1000 µg/mL in methanol
Brand: MedChemExpress
SKU: HY-B0322B
Rating: 5.0 (22 reviews)

Cat. No.: HY-B0322B: Data Sheet
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Sulfamethoxazole (Ro 4-2130) 1000 μg/mL in methanol is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole 1000 μg/mL in methanol inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole 1000 μg/mL in methanol can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis.

For research use only. We do not sell to patients.

CAS No. : 723-46-6

Size	Stock	Quantity
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
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10 g	In-stock	Estimated Time of Arrival: December 31
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Based on 22 publication(s) in Google Scholar

Other Forms of Sulfamethoxazole 1000 µg/mL in methanol:

22 Publications Citing Use of MCE Sulfamethoxazole 1000 µg/mL in methanol

Bio/Physico-chemical Assay

: Sulfamethoxazole 1000 µg/mL in methanol purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]; Heat map of several key genes involved in immunity, metabolism, and circadian rhythm within the gut of juvenile and adult seahorses treated with Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) was constructed using Tbtools software.

: Sulfamethoxazole 1000 µg/mL in methanol purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]; Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) increased the relative abundance of Proteobacteria, whereas decreased the relative abundance of Actinobacteria and Acidobacteria.

: Sulfamethoxazole 1000 µg/mL in methanol purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]; Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) significantly increased the ACE index, but significantly reduced the Simpson's index.

: Sulfamethoxazole 1000 µg/mL in methanol purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]; Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) considerably increased the relative abundances of potential pathogens.

: Sulfamethoxazole 1000 µg/mL in methanol purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]; Sulfamethoxazole (SMX) (1 μg/L; 4 weeks). Heat map of some of representative genes related to immunity and drug metabolism in seahorse brood pouches.

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Description

In Vitro

Sulfamethoxazole (0.01-1.28 mg/mL; 120 h) inhibits P. lutzii mitochondrial activity^[1].
Sulfamethoxazole (0.01 mg/mL; 1-2 h) acts in P. lutzii as a competitor for amino acid, nucleic acids and folate cofactor biosynthesis, disrupting mitochondrial functions^[1].
Sulfamethoxazole at different concentrations, by using the whole-cell patch clamp recording method, inhibits the K_ATP channel currents in mouse pancreatic β cells in a dose-dependent manner, and the IC₅₀ is 0.46 mM^[3].
Sulfamethoxazole at different concentrations, through the static incubation assay of islets, stimulates insulin secretion in mouse islets. It can stimulate insulin secretion at a low concentration (0.1 mM) under high-glucose (10 mM) conditions and only at a high concentration (10 mM) under low-glucose (2 mM) conditions^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	P. lutzii yeast cells
Concentration:	1.28 mg/mL, 0.64 mg/mL, 0.32 mg/mL, 0.16 mg/mL, 0.08 mg/mL, 0.04 mg/mL, 0.02 mg/mL, and 0.01 mg/mL
Incubation Time:	120 h
Result:	Produced a marked dose-dependent adverse effect on P. lutzii.

RT-PCR^[1]

Cell Line:	P. lutzii yeast cells
Concentration:	0.01 mg/mL
Incubation Time:	1 or 2 h
Result:	The up-regulated genes included those for HSP70, HSP60, and HSP30. The down-regulated genes included betaine aldehyde dehydrogenase (BADH), carnitine/acyl carnitine carrier (ACUH), guanine nucleotide binding protein α-1 subunit (GPA2), C6 transcription factor (CTF1B) and pleckstrin homology domain (PH).

Clinical Trial

Molecular Weight

253.28

Formula

C₁₀H₁₁N₃O₃S

CAS No.

723-46-6

Appearance

Solid

Color

White to off-white

SMILES

O=S(NC1=NOC(C)=C1)(C2=CC=C(C=C2)N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥90.0%

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Data Sheet (275 KB) SDS (563 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Zambuzzi-Carvalho et al. Transcriptional profile of the human pathogenic fungus Paracoccidioides lutzii in response to sulfamethoxazole. Med Mycol. 2015;53(5):477-492. [Content Brief]

[2]. Choonara BF, et al. A menthol-based solid dispersion technique for enhanced solubility and dissolution of sulfamethoxazole from an oral tablet matrix. AAPS PharmSciTech. 2015 Aug;16(4):771-86. [Content Brief]

[3]. Ogata H, et al. Dose Dependent Effect of Sulfamethoxazole on Inhibiting KATP Channel of Mouse Pancreatic β Cell. Dose Response. 2023 Sep 28;21(3):15593258231203611. [Content Brief]

Sulfamethoxazole 1000 µg/mL in methanol Related Classifications

Infection

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Sulfamethoxazole 1000 µg/mL in methanol723-46-6Ro 4-2130 1000 µg/mL in methanolAntibioticBacterialInhibitorinhibitorinhibit

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Sulfamethoxazole 1000 µg/mL in methanol (Synonyms: Ro 4-2130 1000 µg/mL in methanol)

Customer Review

Other Forms of Sulfamethoxazole 1000 µg/mL in methanol:

Sulfamethoxazole 1000 µg/mL in methanol Related Antibodies

22 Publications Citing Use of MCE Sulfamethoxazole 1000 µg/mL in methanol

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Sulfamethoxazole 1000 µg/mL in methanol Related Antibodies

Sulfamethoxazole 1000 µg/mL in methanol Related Classifications

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