Sulfamethoxazole sodium
Based on 25 publication(s) in Google Scholar
Sulfamethoxazole (Ro 4-2130) sodium is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole sodium inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole sodium can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis.
For research use only. We do not sell to patients.
- Purity: 99.45%
- CAS No.: 4563-84-2
- Formula: C10H10N3NaO3S
- Molecular Weight:275.26
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Sulfamethoxazole sodium
More- Signal Transduct Target Ther. 2023 Sep 18;8(1):353. [Abstract]
- Autophagy. 2023 Oct;19(10):2702-2718. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- Water Res. 2023 Jul 15:240:120110. [Abstract]
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Food Chem X. 2026 Feb 8:34:103646. [Abstract]
- Int J Biol Macromol. 2026 Mar:352:151224. [Abstract]
- Clin Chem. 2019 Dec;65(12):1522-1531. [Abstract]
- Emerg Contam. 2026 Feb 23.
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Pharmaceutics. 2025 Mar 26;17(4):423. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]
- Antibiotics (Basel). 2026 Mar 10;15(3):283. [Abstract]
- Clean Technol Environ Policy. 2025 May 22.
- Bioresour Technol Rep. 2023 Dec, 24, 101619.
- Microorganisms. 2025 Apr 18;13(4):938. [Abstract]
- Water. 2025 Jun 6.
- Infect Drug Resist. 2026 May 8;19.
- Eur J Clin Microbiol Infect Dis. 2025 Sep 29. [Abstract]
- Res Sq. 2026 Mar 9.
- bioRxiv. 2025 January 19.
- bioRxiv. 2024 May 10.
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
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All Antibiotic Isoforms
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Biological Activity
Sulfamethoxazole (0.01-1.28 mg/mL; 120 h) sodium inhibits P. lutzii mitochondrial activity[1].
Sulfamethoxazole (0.01 mg/mL; 1-2 h) sodium acts in P. lutzii as a competitor for amino acid, nucleic acids and folate cofactor biosynthesis, disrupting mitochondrial functions[1].
Sulfamethoxazole sodium at different concentrations, by using the whole-cell patch clamp recording method, inhibits the KATP channel currents in mouse pancreatic β cells in a dose-dependent manner, and the IC50 is 0.46 mM[3].
Sulfamethoxazole sodium at different concentrations, through the static incubation assay of islets, stimulates insulin secretion in mouse islets. It can stimulate insulin secretion at a low concentration (0.1 mM) under high-glucose (10 mM) conditions and only at a high concentration (10 mM) under low-glucose (2 mM) conditions[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:P. lutzii yeast cells
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Concentration:1.28 mg/mL, 0.64 mg/mL, 0.32 mg/mL, 0.16 mg/mL, 0.08 mg/mL, 0.04 mg/mL, 0.02 mg/mL, and 0.01 mg/mL
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Incubation Time:120 h
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Result:Produced a marked dose-dependent adverse effect on P. lutzii.
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Cell Line:P. lutzii yeast cells
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Concentration:0.01 mg/mL
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Incubation Time:1 or 2 h
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Result:The up-regulated genes included those for HSP70, HSP60, and HSP30.
The down-regulated genes included betaine aldehyde dehydrogenase (BADH), carnitine/acyl carnitine carrier (ACUH), guanine nucleotide binding protein α-1 subunit (GPA2), C6 transcription factor (CTF1B) and pleckstrin homology domain (PH).
Chemical Information
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CAS No. 4563-84-2
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Appearance Solid
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Molecular Weight 275.26
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Formula C10H10N3NaO3S
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Color White to off-white
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SMILES
O=S(C1=CC=C(N)C=C1)([N-]C2=NOC(C)=C2)=O.[Na+]
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Synonyms
Ro 4-2130 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (25)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension. [Abstract]2023 Sep 18;8(1):353. PMID: 37718359 -
Autophagy
2023 Oct;19(10):2702-2718. PMID: 37312409 -
Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
Water Res
Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. [Abstract]2023 Jul 15:240:120110. PMID: 37247434 -
J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Food Chem X
Machine learning prioritization of antibiotic residues in aquatic foods reveals exposure-driven genotoxic risk mediated by BCL2. [Abstract]2026 Feb 8:34:103646. PMID: 41756597 -
Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543 -
Clin Chem
Discovering Cross-Reactivity in Urine Drug Screening Immunoassays through Large-Scale Analysis of Electronic Health Records. [Abstract]2019 Dec;65(12):1522-1531. PMID: 31578215 -
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Pharmaceutics
Plasma Protein Binding, Biostability, Metabolite Profiling, and CYP450 Phenotype of TPB15 Across Different Species: A Novel Smoothened Inhibitor for TNBC Therapy. [Abstract]2025 Mar 26;17(4):423. PMID: 40284418 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Ecotoxicol Environ Saf
Microbial profiles and immune responses in seahorse gut and brood pouch under chronic exposure to environmental antibiotics. [Abstract]2023 Mar 15:253:114711. PMID: 36868035
Sulfamethoxazole sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]
Heat map of several key genes involved in immunity, metabolism, and circadian rhythm within the gut of juvenile and adult seahorses treated with Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) was constructed using Tbtools software.
Sulfamethoxazole sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]
Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) increased the relative abundance of Proteobacteria, whereas decreased the relative abundance of Actinobacteria and Acidobacteria.
Sulfamethoxazole sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]
Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) significantly increased the ACE index, but significantly reduced the Simpson's index.
Sulfamethoxazole sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]
Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) considerably increased the relative abundances of potential pathogens.
Sulfamethoxazole sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711. [Abstract]
Sulfamethoxazole (SMX) (1 μg/L; 4 weeks). Heat map of some of representative genes related to immunity and drug metabolism in seahorse brood pouches.
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Antibiotics (Basel)
Revitalizing Trimethoprim/Sulfamethoxazole via Nanotechnology for Improved Pharmacokinetics and Antibacterial Efficacy. [Abstract]2026 Mar 10;15(3):283. PMID: 41892445 -
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Microorganisms
Isolation, Antimicrobial Susceptibility, and Genotypes of Three Pasteurellaeae Species Prevalent on Pig Farms in China Between 2021 and 2023. [Abstract]2025 Apr 18;13(4):938. PMID: 40284774 -
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Eur J Clin Microbiol Infect Dis
Evaluation of EUCAST rapid antimicrobial susceptibility testing (RAST) for carbapenemase-producing Klebsiella pneumoniae with focus on KPC variants. [Abstract]2025 Sep 29. PMID: 41023358 -
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Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
Solvent & Solubility
H2O : ≥ 100 mg/mL (363.29 mM)
DMSO : 50 mg/mL (181.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Zambuzzi-Carvalho et al. Transcriptional profile of the human pathogenic fungus Paracoccidioides lutzii in response to sulfamethoxazole. Med Mycol. 2015;53(5):477-492. [Content Brief]
[2]. Choonara BF, et al. A menthol-based solid dispersion technique for enhanced solubility and dissolution of sulfamethoxazole from an oral tablet matrix. AAPS PharmSciTech. 2015 Aug;16(4):771-86. [Content Brief]
[3]. Ogata H, et al. Dose Dependent Effect of Sulfamethoxazole on Inhibiting KATP Channel of Mouse Pancreatic β Cell. Dose Response. 2023 Sep 28;21(3):15593258231203611. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.6329 mL | 18.1646 mL | 36.3293 mL | 90.8232 mL |
| 5 mM | 0.7266 mL | 3.6329 mL | 7.2659 mL | 18.1646 mL | |
| 10 mM | 0.3633 mL | 1.8165 mL | 3.6329 mL | 9.0823 mL | |
| 15 mM | 0.2422 mL | 1.2110 mL | 2.4220 mL | 6.0549 mL | |
| 20 mM | 0.1816 mL | 0.9082 mL | 1.8165 mL | 4.5412 mL | |
| 25 mM | 0.1453 mL | 0.7266 mL | 1.4532 mL | 3.6329 mL | |
| 30 mM | 0.1211 mL | 0.6055 mL | 1.2110 mL | 3.0274 mL | |
| 40 mM | 0.0908 mL | 0.4541 mL | 0.9082 mL | 2.2706 mL | |
| 50 mM | 0.0727 mL | 0.3633 mL | 0.7266 mL | 1.8165 mL | |
| 60 mM | 0.0605 mL | 0.3027 mL | 0.6055 mL | 1.5137 mL | |
| 80 mM | 0.0454 mL | 0.2271 mL | 0.4541 mL | 1.1353 mL | |
| 100 mM | 0.0363 mL | 0.1816 mL | 0.3633 mL | 0.9082 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sulfamethoxazole sodium Related Classifications
HY-B0322A Related Classifications
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