4563-84-2
4563-84-2
Chemical Structure
Sulfamethoxazole sodium
Synonym(s): Ro 4-2130 sodium
- CAS. Nr.: 4563-84-2
- Formula:C10H10N3NaO3S
- Molecular Weight:275.26
IUPAC Name: sodium ((4-aminophenyl)sulfonyl)(5-methylisoxazol-3-yl)amide
InChIKey: LARLNXOUTTUXPN-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N)C=C1)([N-]C2=NOC(C)=C2)=O.[Na+]
Biological Activity: Sulfamethoxazole (Ro 4-2130) sodium is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole sodium inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole sodium can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Sulfamethoxazole sodium | 99.18% | Sulfamethoxazole (Ro 4-2130) sodium is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole sodium inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole sodium can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis. | ||||||||||||||||||||
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Sulfamethoxazole sodium (Standard) | 99.71% | Sulfamethoxazole (Standard) (Ro 4-2130 (Standard)) sodium is the analytical standard of Sulfamethoxazole sodium (HY-B0322A). This product is intended for research and analytical applications. Sulfamethoxazole (Ro 4-2130) sodium is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole sodium inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole sodium can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis. | ||||||||||||||||||||
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Sulfatroxazole | Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of ETA receptor (IC50=0.26 μM). | |||||||||||||||||||||
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Sulfamethazine sodium | 99.95% | Sulfamethazine (Sulfadimidine) sodium is a brain-penetrant sulfonamide antibiotic. Sulfamethazine sodium inhibits bacterial growth by blocking the synthesis of folic acid. Sulfamethazine sodium can be used for research on bacterial infections. | ||||||||||||||||||||
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Sulfamethoxazole (Standard) | 99.98% | Sulfamethoxazole (Standard) (Ro 4-2130 (Standard)) is the analytical standard of Sulfamethoxazole (HY-B0322). This product is intended for research and analytical applications. Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis. | ||||||||||||||||||||
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Sulfamethoxazole-13C6 | 99.91% | Sulfamethoxazole-13C6 (Ro 4-2130-13C6) is a 13C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis. | ||||||||||||||||||||
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Sulfathiazole sodium (Standard) | ≥98% | Sulfathiazole sodium (Standard) is the analytical standard of Berberine sodium (HY-B0507A). This product is intended for research and analytical applications. Sulfathiazole sodium is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole sodium increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish. Sulfathiazole sodium is also a cathodic corrosion inhibitor. Sulfathiazole sodium inhibits the corrosion of copper by chloride ions through chemical and physical adsorption on the copper surface, reduces the corrosion current density and shifts the corrosion potential negatively. | ||||||||||||||||||||
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Sulfamerazine sodium | Sulfamerazine (RP2632) sodium is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine sodium inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine sodium inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine sodium can be used for the research of Parkinson’s disease and bacterial infection. | |||||||||||||||||||||
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Sulfachloropyridazine sodium | 99.34% | Sulfachloropyridazine (sodium) is a sulfonamide antibiotic that inhibits bacterial growth. | ||||||||||||||||||||
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N4-Acetylsulfamethoxazole | 99.72% | N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is the N4-acetylated metabolite of Sulfamethoxazole (HY-B0322). | ||||||||||||||||||||
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Sulfamonomethoxine sodium (Standard) | ≥98% | Sulfamonomethoxine sodium (Standard) is the analytical standard of Sulfamonomethoxine sodium. This product is intended for research and analytical applications. Sulfamonomethoxine sodium is an orally active broad-spectrum synthetic sulfonamide antibiotic that inhibits dihydropteroate synthetase. Sulfamonomethoxine sodium increases blood glucose levels, induces anxiety-related activities and impairs spatial learning and memory. Sulfamonomethoxine sodium can be used for the research of anxiety, spatial memory impairment, colisepticemia, salmonellosis, and staphylococcus infection. | ||||||||||||||||||||
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Sulfamethoxazole-NO | Sulfamethoxazole-NO (SMX-NO) is a haptenizing immunogen. Sulfamethoxazole-NO reduces NF-kB signaling, induces AP-1 signaling, and depletes cysteine, glutathione, and ascorbic acid. Sulfamethoxazole-NO forms covalently haptenized proteins and antigens, activates MHC-restricted T cells and CD4+ T cells, and upregulates dendritic cell CD40. Sulfamethoxazole-NO induces apoptosis, necrosis, methemoglobin formation, and cytotoxicity accompanied by loss of membrane integrity. Sulfamethoxazole-NO inhibits neutrophil function and oxidative metabolism. Sulfamethoxazole-NO can be used for research on hypersensitivity reactions. | |||||||||||||||||||||
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References
- [1]. Zambuzzi-Carvalho et al. Transcriptional profile of the human pathogenic fungus Paracoccidioides lutzii in response to sulfamethoxazole. Med Mycol. 2015;53(5):477-492. [Content Brief]
- [2]. Choonara BF, et al. A menthol-based solid dispersion technique for enhanced solubility and dissolution of sulfamethoxazole from an oral tablet matrix. AAPS PharmSciTech. 2015 Aug;16(4):771-86. [Content Brief]
- [3]. Ogata H, et al. Dose Dependent Effect of Sulfamethoxazole on Inhibiting KATP Channel of Mouse Pancreatic β Cell. Dose Response. 2023 Sep 28;21(3):15593258231203611. [Content Brief]
