Sulfamerazine sodium
Based on 4 publication(s) in Google Scholar
Sulfamerazine (RP2632) sodium is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine sodium inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine sodium inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine sodium can be used for the research of Parkinson’s disease and bacterial infection.
For research use only. We do not sell to patients.
- CAS No.: 127-58-2
- Formula: C11H11N4NaO2S
- Molecular Weight:286.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Sulfamerazine sodium
MoreAll Antibiotic Isoforms
MoreAll α-synuclein Isoforms
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Biological Activity
Sulfamerazine (5-25 μM) sodium reproducibly inhibits α-Syn fibrillation[1].
Sulfamerazine (25-100 μM) sodium exhibits a significant reduction in α-Syn aggregation and associated toxicity in Caenorhabditis elegans model of PD[1].
Sulfamerazine (25-200 μM; 24-48 h) sodium is nontoxic to human neuroblastoma SH-SY5Y cells at concentrations up to 100 μM over 24-48 h, with reduced viability observed only at 200 μM[1].
Sulfamerazine (0.31 μM; 24 h) sodium reduces the accumulation of α-Syn aggregates in neuronal SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human neuroblastoma SH-SY5Y cells
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Concentration:25 μM; 50 μM; 100 μM; 200 μM
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Incubation Time:24 h; 48 h
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Result:Showed no significant toxicity up to 100 μM after 24 h and 48 h.
Decreased cell viability to ~70% at 200 μM after 24 h and ~40% at 200 μM after 48 h.
Chemical Information
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CAS No. 127-58-2
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Molecular Weight 286.29
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Formula C11H11N4NaO2S
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SMILES
O=S([N-]C1=NC=CC(C)=N1)(C2=CC=C(N)C=C2)=O.[Na+]
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Synonyms
RP2632 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380 -
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sulfamerazine sodium Related Classifications
HY-B0512A Related Classifications
Powered by Bioz
- Sulfamerazine
- 127-58-2
- RP2632
- RP 2632
- RP-2632
- Antibiotic
- Bacterial
- α-synuclein
- Parkinson’s disease
- Ure2
- Caenorhabditis elegans
- bacillus coli urinary tract infections
- meningococcic meningitis
- gonococcic infections
- beta-hemolytic streptococcus infections
- staphylococcic infections
- pneumococcic infections
- Inhibitor
- inhibitor
- inhibit