2. Anti-infection Neuronal Signaling
  3. Antibiotic Bacterial α-synuclein
  4. Sulfamerazine sodium

Sulfamerazine (RP2632) sodium is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine sodium inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine sodium inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine sodium can be used for the research of Parkinson’s disease and bacterial infection.

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Sulfamerazine sodium

Sulfamerazine sodium Chemical Structure

CAS No. : 127-58-2

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Sulfamerazine sodium Related Antibodies

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Description

Sulfamerazine (RP2632) sodium is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine sodium inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine sodium inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine sodium can be used for the research of Parkinson’s disease and bacterial infection[1][2].

In Vitro

Sulfamerazine (5-25 μM) sodium reproducibly inhibits α-Syn fibrillation[1].
Sulfamerazine (25-100 μM) sodium exhibits a significant reduction in α-Syn aggregation and associated toxicity in Caenorhabditis elegans model of PD[1].
Sulfamerazine (25-200 μM; 24-48 h) sodium is nontoxic to human neuroblastoma SH-SY5Y cells at concentrations up to 100 μM over 24-48 h, with reduced viability observed only at 200 μM[1].
Sulfamerazine (0.31 μM; 24 h) sodium reduces the accumulation of α-Syn aggregates in neuronal SH-SY5Y cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfamerazine sodium Related Antibodies

Cell Viability Assay[1]

Cell Line: human neuroblastoma SH-SY5Y cells
Concentration: 25 μM; 50 μM; 100 μM; 200 μM
Incubation Time: 24 h; 48 h
Result: Showed no significant toxicity up to 100 μM after 24 h and 48 h.
Decreased cell viability to ~70% at 200 μM after 24 h and ~40% at 200 μM after 48 h.
Molecular Weight

286.29

Formula

C11H11N4NaO2S
CAS No.
SMILES

O=S([N-]C1=NC=CC(C)=N1)(C2=CC=C(N)C=C2)=O.[Na+]
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Sulfamerazine sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfamerazine127-58-2RP2632RP 2632RP-2632AntibioticBacterialα-synucleinα-SynParkinson’s diseaseUre2Caenorhabditis elegansbacillus coli urinary tract infectionsmeningococcic meningitisgonococcic infectionsbeta-hemolytic streptococcus infectionsstaphylococcic infectionspneumococcic infectionsInhibitorinhibitorinhibit

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