127-58-2
Chemical Structure
Sulfamerazine sodium
Synonym(s): RP2632 sodium
- CAS No.: 127-58-2
- Formula:C11H11N4NaO2S
- Molecular Weight:286.29
IUPAC Name: sodium ((4-aminophenyl)sulfonyl)(4-methylpyrimidin-2-yl)amide
InChIKey: BSFJGCCAXDCMOX-UHFFFAOYSA-N
SMILES: O=S([N-]C1=NC=CC(C)=N1)(C2=CC=C(N)C=C2)=O.[Na+]
Biological Activity: Sulfamerazine (RP2632) sodium is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine sodium inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine sodium inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine sodium can be used for the research of Parkinson’s disease and bacterial infection[1][2].
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Sulfamerazine sodium | Sulfamerazine (RP2632) sodium is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine sodium inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine sodium inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine sodium can be used for the research of Parkinson’s disease and bacterial infection. | |||||||||||||||||||||
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- [1]. Singh P, et al. Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity. ACS Chem Neurosci. 2025 Mar 5;16(5):880-894. [Content Brief]
- [2]. Hageman PO, et al. Sulfamerazine: A Clinical Study of Its Pharmacodynamics, Therapeutic Value and Toxicity. JAMA. 1943 Oct 9;123(6):325-330.
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