Art. -Nr.: HY-B0035A

Sulfamethazine sodium

Name: Sulfamethazine sodium
Brand: MedChemExpress
SKU: HY-B0035A
Price: 30.00 USD
Availability: InStock
Rating: 5 (3 reviews)

(Synonyms: Sulfadimidine sodium; Sulfadimerazine sodium)

3 Cited Publications

Kundenbewertung

Based on 3 publication(s) in Google Scholar

Sulfamethazine (Sulfadimidine) sodium is a brain-penetrant sulfonamide antibiotic. Sulfamethazine sodium inhibits bacterial growth by blocking the synthesis of folic acid. Sulfamethazine sodium can be used for research on bacterial infections.

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Reinheit: 99.95%
CAS. Nr.: 1981-58-4
Formel: C₁₂H₁₃N₄NaO₂S
Molecular Weight:300.31

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Sulfamethazine sodium Chemical Structure

CAS. Nr.: 1981-58-4

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HY-B0035AR
Sulfamethazine sodium (Standard)

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Bacterial^[1]

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vivo

Sulfamethazine (0.3 g/kg; i.m.; single dose) sodium demonstrates restricted passage across the blood-brain barrier in adult pregnant and non-pregnant Wistar rats, with brain levels consistently reaching 30-37% of corresponding blood levels^[1].
Sulfamethazine (80 mg/kg; i.v.; single dose) sodium treatment significantly reduced α, β and AUC_0-∞, and significantly increased t_1/2α, V_d and CIB, with an absolute bioavailability of 1.01^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (adult female, pregnant and non-pregnant)^[2]
Dosage:

0.3 g/kg
Administration:

i.m.; single dose
Result:

Measured blood sulfamethazine level of 17.27 mg/100 mL and brain level of 5.71 mg/100 mL (33% of blood level) at 60 minutes in gestational day 10 pregnant rats receiving carbadox.
Reached peak blood sulfamethazine level of 22.23 mg/100 mL and brain level of 8.30 mg/100 mL (37% of blood level) at 120 minutes in gestational day 10 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 15.55 mg/100 mL and brain level of 5.11 mg/100 mL (32% of blood level) at 240 minutes in gestational day 10 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 23.44 mg/100 mL and brain level of 7.35 mg/100 mL (31% of blood level) at 60 minutes in gestational day 20 pregnant rats receiving carbadox.
Reached peak blood sulfamethazine level of 31.51 mg/100 mL and brain level of 11.11 mg/100 mL (35% of blood level) at 120 minutes in gestational day 20 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 25.20 mg/100 mL and brain level of 8.30 mg/100 mL (32% of blood level) at 240 minutes in gestational day 20 pregnant rats receiving carbadox.
Measured blood sulfamethazine level of 17.24 mg/100 mL and brain level of 5.15 mg/100 mL (30% of blood level) at 60 minutes in gestational day 10 pregnant rats not receiving carbadox.
Reached peak blood sulfamethazine level of 22.75 mg/100 mL and brain level of 8.25 mg/100 mL (36% of blood level) at 120 minutes in gestational day 10 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 15.80 mg/100 mL and brain level of 5.15 mg/100 mL (32% of blood level) at 240 minutes in gestational day 10 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 23.78 mg/100 mL and brain level of 8.05 mg/100 mL (33% of blood level) at 60 minutes in gestational day 20 pregnant rats not receiving carbadox.
Reached peak blood sulfamethazine level of 30.72 mg/100 mL and brain level of 10.83 mg/100 mL (35% of blood level) at 120 minutes in gestational day 20 pregnant rats not receiving carbadox.
Measured blood sulfamethazine level of 25.68 mg/100 mL and brain level of 8.77 mg/100 mL (34% of blood level) at 240 minutes in gestational day 20 pregnant rats not receiving carbadox.
Observed slightly higher blood sulfamethazine levels in pregnant rats than non-pregnant counterparts, and higher levels in 20-day pregnant rats than 10-day pregnant rats.
Detected no significant difference in sulfamethazine levels in blood and brain between rats receiving carbadox and those that did not.

Chemical Information

CAS. Nr. 1981-58-4
Appearance Solid
Molecular Weight 300.31
Formel C₁₂H₁₃N₄NaO₂S
Color White to off-white
SMILES

O=S(C1=CC=C(N)C=C1)([N-]C2=NC(C)=CC(C)=N2)=O.[Na+]
Synonyms

Sulfadimidine sodium; Sulfadimerazine sodium
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (3)

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Journal Impact Factor

ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Chemosphere

Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]

2019 Jun:225:378-387. PMID: 30884299

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 250 mg/mL (832.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (332.99 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3299 mL

16.6495 mL

33.2989 mL

5 mM

0.6660 mL

3.3299 mL

6.6598 mL

10 mM

0.3330 mL

1.6649 mL

3.3299 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (6.93 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. VAN Poucke LSG, et al. Pharmacokinetics and Tissue Residues of Sulfathiazole and Sulfamethazine in Pigs. J Food Prot. 1994 Sep;57(9):796-801. [Content Brief]

[2]. Sheng Y J, et al. Production of chicken yolk IgY to sulfamethazine: comparison with rabbit antiserum IgG. Food and Agricultural Immunology. 2015, 26(3):305-316.

[3]. Siddique A B, et al. Effect of Carbadox on the Passage of Sulfamethazine through the Blood-Brain Barrier in Rat[J]. Acta Veterinaria Brno, 1979, 48(1-4): 79-84.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	3.3299 mL	16.6495 mL	33.2989 mL	83.2473 mL
	5 mM	0.6660 mL	3.3299 mL	6.6598 mL	16.6495 mL
	10 mM	0.3330 mL	1.6649 mL	3.3299 mL	8.3247 mL
	15 mM	0.2220 mL	1.1100 mL	2.2199 mL	5.5498 mL
	20 mM	0.1665 mL	0.8325 mL	1.6649 mL	4.1624 mL
	25 mM	0.1332 mL	0.6660 mL	1.3320 mL	3.3299 mL
	30 mM	0.1110 mL	0.5550 mL	1.1100 mL	2.7749 mL
	40 mM	0.0832 mL	0.4162 mL	0.8325 mL	2.0812 mL
	50 mM	0.0666 mL	0.3330 mL	0.6660 mL	1.6649 mL
	60 mM	0.0555 mL	0.2775 mL	0.5550 mL	1.3875 mL
	80 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0406 mL
	100 mM	0.0333 mL	0.1665 mL	0.3330 mL	0.8325 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

Sulfamethazine sodium

3 Cited Publications

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Sulfamethazine sodium

Publications Citing Use of MedChemExpress (MCE) Sulfamethazine sodium

Alle Antibiotic Isoform-spezifische Produkte anzeigen