2. Anti-infection
  3. Bacterial Antibiotic
  4. Sulfamethazine sodium

Sulfamethazine sodium  (Synonyms: Sulfadimidine sodium; Sulfadimerazine sodium)

Cat. No.: HY-B0035A Purity: 99.90%
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Sulfamethazine sodium (Sulfadimidine sodium) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg.

For research use only. We do not sell to patients.

Sulfamethazine sodium Chemical Structure

Sulfamethazine sodium Chemical Structure

CAS No. : 1981-58-4

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Based on 1 publication(s) in Google Scholar

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Sulfamethazine sodium Related Antibodies

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Description

Sulfamethazine sodium (Sulfadimidine sodium) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg[1][2].

IC50 & Target

Bacterial[1]
In Vivo

Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 19 healthy female pigs (6-week-old, 4.5-6.2 kg)[1]
Dosage: 80 mg/kg
Administration: Intravenous injection (Pharmacokinetic study)
Result: The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.
Molecular Weight

300.31

Formula

C12H13N4NaO2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(N)C=C1)([N-]C2=NC(C)=CC(C)=N2)=O.[Na+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (832.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (332.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3299 mL 16.6495 mL 33.2989 mL
5 mM 0.6660 mL 3.3299 mL 6.6598 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (6.93 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.3299 mL 16.6495 mL 33.2989 mL 83.2473 mL
5 mM 0.6660 mL 3.3299 mL 6.6598 mL 16.6495 mL
10 mM 0.3330 mL 1.6649 mL 3.3299 mL 8.3247 mL
15 mM 0.2220 mL 1.1100 mL 2.2199 mL 5.5498 mL
20 mM 0.1665 mL 0.8325 mL 1.6649 mL 4.1624 mL
25 mM 0.1332 mL 0.6660 mL 1.3320 mL 3.3299 mL
30 mM 0.1110 mL 0.5550 mL 1.1100 mL 2.7749 mL
40 mM 0.0832 mL 0.4162 mL 0.8325 mL 2.0812 mL
50 mM 0.0666 mL 0.3330 mL 0.6660 mL 1.6649 mL
60 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3875 mL
80 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0406 mL
100 mM 0.0333 mL 0.1665 mL 0.3330 mL 0.8325 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sulfamethazine sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfamethazine1981-58-4SulfadimidineSulfadimerazineBacterialAntibioticInhibitorinhibitorinhibit

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