1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Ampicillin

Ampicillin (Synonyms: D-(-)-α-Aminobenzylpenicillin)

Cat. No.: HY-B0522 Purity: 98.27%
Handling Instructions

Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

For research use only. We do not sell to patients.

Ampicillin Chemical Structure

Ampicillin Chemical Structure

CAS No. : 69-53-4

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Ampicillin:

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Description

Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

In Vitro

Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ampicillin is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig[1]. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood[2]. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

349.40

Formula

C₁₆H₁₉N₃O₄S

CAS No.

69-53-4

SMILES

OC([[email protected]@H]1N(C2=O)[[email protected]]([[email protected]@H]2NC([[email protected]@H](C3=CC=CC=C3)N)=O)([H])SC1(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

0.1 M NaOH : 25 mg/mL (71.55 mM; Need ultrasonic)

H2O : 5 mg/mL (14.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8620 mL 14.3102 mL 28.6205 mL
5 mM 0.5724 mL 2.8620 mL 5.7241 mL
10 mM 0.2862 mL 1.4310 mL 2.8620 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[3]

Mice: Ampicillin is dissolved in normal saline. Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral common carotid artery occlusion for 40 min. Before transient forebrain ischemia, ampicillin (200 mg/kg, intraperitoneally [i.p.]) or penicillin G (6,000 U/kg or 20,000 U/kg, i.p.) was administered daily for 5 days. In the control animals, saline was administered at the same volume and time schedule[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 98.27%

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Keywords:

AmpicillinD-(-)-α-AminobenzylpenicillinBacterialAntibioticInhibitorinhibitorinhibit

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