Ampicillin
Based on 80 publication(s) in Google Scholar
Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 69-53-4
- Formula: C16H19N3O4S
- Molecular Weight:349.40
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ampicillin
More- Science. 2026 Mar 19;391(6791):eadu7686. [Abstract]
- Cancer Cell. 2026 Feb 9;44(2):306-320.e7. [Abstract]
- Cancer Cell. 2025 Sep 25:S1535-6108(25)00394-0. [Abstract]
- Cell Metab. 2025 Jan 7;37(1):87-103.e10. [Abstract]
- Cell Metab. 2023 Nov 7;35(11):1961-1975.e6. [Abstract]
- Immunity. 2026 Mar 27:S1074-7613(26)00086-5. [Abstract]
- Exploration. 2025 Dec 18;5(6):20240396. [Abstract]
- Cell Host Microbe. 2025 Jun 11;33(6):915-931.e9. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- Adv Sci (Weinh). 2026 Jan 8:e17257. [Abstract]
- Adv Sci (Weinh). 2025 Apr 28:e2409837. [Abstract]
- Nucleic Acids Res. 2022 Dec 9;50(22):12951-12968. [Abstract]
- J Nanobiotechnology. 2024 Nov 30;22(1):744. [Abstract]
- Sci Adv. 2023 Feb 17;9(7):eade4770. [Abstract]
- Gut Microbes. 2026 Dec 31;18(1):2620125. [Abstract]
- Gut Microbes. 2023 Dec;15(2):2282790. [Abstract]
- Gut Microbes. 2023 Dec;15(2):2249143. [Abstract]
- Nano Today. 2025 Oct.
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Cell Rep Med. 2025 Oct 21;6(10):102410. [Abstract]
- Cell Rep Med. 2023 Dec 19;4(12):101340. [Abstract]
- Pharmacol Res. 2024 May 21:205:107229. [Abstract]
- J Neuroinflammation. 2025 Nov 4;22(1):259. [Abstract]
- Genome Biol. 2023 Apr 30;24(1):98. [Abstract]
- J Pharm Anal. 2023 Oct;13(10):1153-1167. [Abstract]
- Cancer Immunol Res. 2022 Dec 2;10(12):1542-1558. [Abstract]
- Chemosphere. 2023 Dec:344:140353. [Abstract]
- Biomed Pharmacother. 2025 Jan:182:117756. [Abstract]
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- Emerg Microbes Infect. 2022 Dec;11(1):815-828. [Abstract]
- Curr Res Food Sci. 2025 May 16:10:101084. [Abstract]
- Neural Regen Res. 2024 Sep 1;19(9):2081-2088. [Abstract]
- J Agric Food Chem. 2024 Apr 10. [Abstract]
- Chin Med. 2025 Oct 3;20(1):155. [Abstract]
- Biochem Pharmacol. 2024 Dec;230(Pt 2):116593. [Abstract]
- Am J Chin Med. 2024 Aug 21:1-28. [Abstract]
- Food Funct. 2026 Apr 14;17(7):3324-3335. [Abstract]
- Life Sci. 2020 Nov 15;261:118473. [Abstract]
- Nutrients. 2023 Oct 18;15(20):4427. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- mSystems. 2023 Dec 21;8(6):e0102623. [Abstract]
- Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0037925. [Abstract]
- Front Aging Neurosci. 2022 Jul 28;14:858130. [Abstract]
- ACS Omega. 2023 Mar 6;8(10):9652-9661. [Abstract]
- Microorganisms. 2026 Mar 23;14(3):725. [Abstract]
- Microorganisms. 2025 Apr 18;13(4):938. [Abstract]
- Microorganisms. 2024 Mar 13;12(3):575. [Abstract]
- iScience. 2025 May 27;28(6):112763. [Abstract]
- iScience. 2025 May 13;28(7):112658. [Abstract]
- iScience. 2023 Oct 7;26(11):108158. [Abstract]
- iScience. 2023 Mar 11;26(4):106378. [Abstract]
- J Cell Physiol. 2022 Mar;237(3):1845-1856. [Abstract]
- Aquaculture. 2021, 736248.
- Microbiol Spectr. 2026 Mar 23:e0328925. [Abstract]
- ACS Infect Dis. 2024 Aug 9;10(8):2961-2977. [Abstract]
- ACS Infect Dis. 2023 Dec 8;9(12):2523-2537. [Abstract]
- Microbiol Spectr. 2022 Feb 23;10(1):e0099121. [Abstract]
- AMB Express. 2024 Dec 24;14(1):141. [Abstract]
- J Antimicrob Chemother. 2024 Jul 20:dkae218. [Abstract]
- J Antimicrob Chemother. 2024 Jul 13:dkae229. [Abstract]
- Heliyon. 2024 Jun 6;10(11):e32429. [Abstract]
- J Antimicrob Chemother. 2023 Apr 3;78(4):983-990. [Abstract]
- Life Metab. 2025 Oct 8.
- Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr;398(4):3681-3695. [Abstract]
- Vet Microbiol. 2024 May:292:110046. [Abstract]
- Infect Genet Evol. 2025 Sep:133:105780. [Abstract]
- Protoplasma. 2025 Nov 6. [Abstract]
- Biomed Res Int. 2018 Jul 2:2018:3579832. [Abstract]
- Biochem Biophys Res Commun. 2025 Jun 7:776:152161. [Abstract]
- Vet Res Commun. 2024 Dec;48(6):3859-3872. [Abstract]
- Anim Dis. 2021;1(1):26. [Abstract]
- Diagn Microbiol Infect Dis. 2026 Feb;114(2):117181. [Abstract]
- Res Sq. 2025 Aug 05.
- bioRxiv. 2025 February 13.
- bioRxiv. 2025 January 19.
- Res Sq. 2024 Oct 02.
- bioRxiv. 2024 May 10.
- SSRN. 2023 Sep 11.
- Research Square Preprint. 2021 Feb.
- Research Square Preprint. 2020 Jun.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Microbiological Assay
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Microbiological Assay
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PK/PD Analysis
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Bio/Physico-chemical Assay
All Antibiotic Isoforms
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Biological Activity
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β-lactam |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
10 mM
Compound: Ampicillin
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TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 25000 uM) in PEPT1-expressing CHO cells
TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 25000 uM) in PEPT1-expressing CHO cells
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[PMID: 8956326] |
| Erythrocyte | IC50 |
0.9 μM
Compound: Ampicillin
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Hemolytic activity against human RBC incubated for 1 hr by microplate reader analysis
Hemolytic activity against human RBC incubated for 1 hr by microplate reader analysis
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[PMID: 39116273] |
| HEK293 | CC50 |
>100 μM
Compound: Ampicillin
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay
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[PMID: 30392371] |
Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 69-53-4
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Appearance Solid
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Molecular Weight 349.40
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Formula C16H19N3O4S
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Color White to off-white
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SMILES
OC([C@@H]1N(C2=O)[C@]([C@@H]2NC([C@@H](C3=CC=CC=C3)N)=O)([H])SC1(C)C)=O
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Synonyms
D-(-)-α-Aminobenzylpenicillin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (80)
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Journal Impact Factor
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Most Recent
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Science
Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors. [Abstract]2026 Mar 19;391(6791):eadu7686. PMID: 41855345 -
Cancer Cell
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage. [Abstract]2026 Feb 9;44(2):306-320.e7. PMID: 41512867 -
Cancer Cell
Ketogenic diet inhibits glioma progression by promoting gut microbiota-derived butyrate production. [Abstract]2025 Sep 25:S1535-6108(25)00394-0. PMID: 41005305 -
Cell Metab
Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon. [Abstract]2025 Jan 7;37(1):87-103.e10. PMID: 39366386 -
Cell Metab
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate. [Abstract]2023 Nov 7;35(11):1961-1975.e6. PMID: 37797623 -
Immunity
NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells. [Abstract]2026 Mar 27:S1074-7613(26)00086-5. PMID: 41903549 -
Exploration
A Bioorthogonal and Programmable Bacterial Delivery System for Spatiotemporally Targeted Therapy of Solid Tumors. [Abstract]2025 Dec 18;5(6):20240396. PMID: 41476656 -
Cell Host Microbe
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy. [Abstract]2025 Jun 11;33(6):915-931.e9. PMID: 40441145 -
Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
Adv Sci (Weinh)
Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles. [Abstract]2026 Jan 8:e17257. PMID: 41504389 -
Adv Sci (Weinh)
Microbiota-Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration. [Abstract]2025 Apr 28:e2409837. PMID: 40289872 -
Nucleic Acids Res
RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation. [Abstract]2022 Dec 9;50(22):12951-12968. PMID: 36503967 -
J Nanobiotechnology
Enhancing radiotherapy in triple-negative breast cancer with hesperetin-induced ferroptosis via AURKA targeting nanocomposites. [Abstract]2024 Nov 30;22(1):744. PMID: 39614277 -
Sci Adv
Imaging of Escherichia coli K5 and glycosaminoglycan precursors via targeted metabolic labeling of capsular polysaccharides in bacteria. [Abstract]2023 Feb 17;9(7):eade4770. PMID: 36800421 -
Gut Microbes
Gut microbial ammonia as a mediator of PFOS neurotoxicity and its remediation by the flavonoid Icaritin. [Abstract]2026 Dec 31;18(1):2620125. PMID: 41629743 -
Gut Microbes
Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 mice. [Abstract]2023 Dec;15(2):2282790. PMID: 37992400
Ampicillin purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2023 Dec;15(2):2282790. [Abstract]
Depletion of CD8+ T cells in ABX-treated B16-F0 tumor-bearing mice dampened the antitumor effect of butyrate combined with anti-PD-1 (Figure 4b–e). Decreased serum IFN-γ and TNF-α production during the depletion of CD8+ T cells was also observed. ABX：an antibiotic cocktail of 0.5 g/L Vancomycin, 1 g/L Metronidazole, 1 g/L Neomycin and 1 g/L Ampicillin.
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Gut Microbes
Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell. [Abstract]2023 Dec;15(2):2249143. PMID: 37635362
Ampicillin purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2023 Dec;15(2):2249143. [Abstract]
Targeted metabolomics analysis of gut microbial metabolites (AA, PA, and BA) in colon contents (feces) and serum from mice with or without ABX treatment (n = 6 per group). ABX: an antibiotic cocktail of 0.5 g/L Vancomycin, 1 g/L Metronidazole,1 g/L Neomycin and 1 g/L Ampicillin
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657
Ampicillin purchased from MedChemExpress. Usage Cited in: J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
Optical density at 600 nm was measured for each culture and normalized to the media (e.g. Ampicillin).
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Cell Rep Med
Intestinal Lachnospiraceae bacterium-derived propionate inhibits the progression of clear cell renal cell carcinoma. [Abstract]2025 Oct 21;6(10):102410. PMID: 41067230 -
Cell Rep Med
Attenuation of allergen-specific immunotherapy for atopic dermatitis by ectopic colonization of Brevundimonas vesicularis in the intestine. [Abstract]2023 Dec 19;4(12):101340. PMID: 38118418 -
Pharmacol Res
Multi-omics approaches for the understanding of therapeutic mechanism for Huang-Qi-Long-Dan Granule against ischemic stroke. [Abstract]2024 May 21:205:107229. PMID: 38782148 -
J Neuroinflammation
The gut microbiota limits systemic inflammation during neurotrophic viral CNS infection by priming tonic type I interferon signaling. [Abstract]2025 Nov 4;22(1):259. PMID: 41189008 -
Genome Biol
Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota. [Abstract]2023 Apr 30;24(1):98. PMID: 37122023 -
J Pharm Anal
Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling. [Abstract]2023 Oct;13(10):1153-1167. PMID: 38024855 -
Cancer Immunol Res
NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy. [Abstract]2022 Dec 2;10(12):1542-1558. PMID: 36255412 -
Chemosphere
Sustainable production of Fe-doped MnO2 nanoparticles for accelerated tetracycline antibiotic detoxification. [Abstract]2023 Dec:344:140353. PMID: 37797898 -
Biomed Pharmacother
Identification of the atypical antipsychotic Asenapine as a direct survivin inhibitor with anticancer properties and sensitizing effects to conventional therapies. [Abstract]2025 Jan:182:117756. PMID: 39693907 -
Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
Emerg Microbes Infect
2022 Dec;11(1):815-828. PMID: 35191819 -
Curr Res Food Sci
Gallic acid prevents obesity in mice on a high-fat diet via the gut microbiota-adipose tissue axis. [Abstract]2025 May 16:10:101084. PMID: 40491530 -
Neural Regen Res
Gut microbiota dysbiosis contributes to α-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson's disease. [Abstract]2024 Sep 1;19(9):2081-2088. PMID: 38227539 -
J Agric Food Chem
Lactiplantibacillus plantarum-Derived Indole-3-lactic Acid Ameliorates Intestinal Barrier Integrity through the AhR/Nrf2/NF-κB Axis. [Abstract]2024 Apr 10. PMID: 38597152 -
Chin Med
Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis. [Abstract]2025 Oct 3;20(1):155. PMID: 41039626 -
Biochem Pharmacol
MNAM enhances Blautia abundance and modulates Th17/Treg balance to alleviate diabetes in T2DM mice. [Abstract]2024 Dec;230(Pt 2):116593. PMID: 39454734 -
Am J Chin Med
Astragaloside IV Ameliorates Colonic Adenomatous Polyps Development by Orchestrating Gut Bifidobacterium and Serum Metabolome. [Abstract]2024 Aug 21:1-28. PMID: 39164214 -
Food Funct
Tryptophan metabolites derived from Lactiplantibacillus plantarum Y42 regulate the AhR/Nrf2/NF-κB axis to ameliorate colitis in mice. [Abstract]2026 Apr 14;17(7):3324-3335. PMID: 41860418 -
Life Sci
Electroacupuncture preserves intestinal barrier integrity through modulating the gut microbiota in DSS-induced chronic colitis. [Abstract]2020 Nov 15;261:118473. PMID: 32971101 -
Nutrients
Ketogenic Diet Exacerbates L-Arginine-Induced Acute Pancreatitis and Reveals the Therapeutic Potential of Butyrate. [Abstract]2023 Oct 18;15(20):4427. PMID: 37892502 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
mSystems
2023 Dec 21;8(6):e0102623. PMID: 38047647 -
Antimicrob Agents Chemother
Activity of ampicillin-sulbactam, sulbactam-durlobactam, and comparators against Acinetobacter baumannii-calcoaceticus complex strains isolated from respiratory and bloodstream sources: results from ACNBio study. [Abstract]2025 Aug 6;69(8):e0037925. PMID: 40673757 -
Front Aging Neurosci
Transplantation of fecal microbiota from APP/PS1 mice and Alzheimer's disease patients enhanced endoplasmic reticulum stress in the cerebral cortex of wild-type mice. [Abstract]2022 Jul 28;14:858130. PMID: 35966768 -
ACS Omega
In Vitro Inhibition of Growth, Biofilm Formation, and Persisters of Staphylococcus aureus by Pinaverium Bromide. [Abstract]2023 Mar 6;8(10):9652-9661. PMID: 36936302 -
Microorganisms
Monosodium Glutamate Inhibits Pseudomonas aeruginosa-Induced Acute Lung Injury by Targeting the Type III Secretion Systems and Modulating Host Immunity. [Abstract]2026 Mar 23;14(3):725. PMID: 41900484 -
Microorganisms
Isolation, Antimicrobial Susceptibility, and Genotypes of Three Pasteurellaeae Species Prevalent on Pig Farms in China Between 2021 and 2023. [Abstract]2025 Apr 18;13(4):938. PMID: 40284774 -
Microorganisms
Antimicrobial Resistance and Genomic Characteristics of Escherichia coli Strains Isolated from the Poultry Industry in Henan Province, China. [Abstract]2024 Mar 13;12(3):575. PMID: 38543626
Ampicillin purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575. [Abstract]
Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.
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iScience
Gut microbiota from voluntary exercised mice protects the intestinal barrier by inhibiting neutrophil extracellular trap formation. [Abstract]2025 May 27;28(6):112763. PMID: 40585508 -
iScience
AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease. [Abstract]2025 May 13;28(7):112658. PMID: 40687779 -
iScience
Analysis of microbiota reveals the underlying mechanism of PHF11 in the development of Enterococcus-regulated endometriotic cysts. [Abstract]2023 Oct 7;26(11):108158. PMID: 37915596 -
iScience
Cinacalcet exhibits rapid bactericidal and efficient anti-biofilm activities against multidrug-resistant Gram-positive pathogens. [Abstract]2023 Mar 11;26(4):106378. PMID: 37034999 -
J Cell Physiol
Lactobacillus plantarum alleviates irradiation-induced intestinal injury by activation of FXR-FGF15 signaling in intestinal epithelia. [Abstract]2022 Mar;237(3):1845-1856. PMID: 34881818 -
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Microbiol Spectr
Antimicrobial activity of sulbactam-durlobactam against Acinetobacter baumannii-calcoaceticus complex strains causing non-respiratory and non-bloodstream infections from the United States (2023-2025). [Abstract]2026 Mar 23:e0328925. PMID: 41869812 -
ACS Infect Dis
Loratadine Derivative Lo-7: A Weapon against Drug-Resistant Enterococcus and Streptococcal Infections. [Abstract]2024 Aug 9;10(8):2961-2977. PMID: 39066703 -
ACS Infect Dis
Thiazolopyrimidinone Derivative H5-23 Enhances Daptomycin Activity against Linezolid-Resistant Enterococcus faecalis by Disrupting the Cell Membrane. [Abstract]2023 Dec 8;9(12):2523-2537. PMID: 38014911 -
Microbiol Spectr
The Mechanism of Action of Ginkgolic Acid (15:1) against Gram-Positive Bacteria Involves Cross Talk with Iron Homeostasis. [Abstract]2022 Feb 23;10(1):e0099121. PMID: 35019708 -
AMB Express
Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]2024 Dec 24;14(1):141. PMID: 39718732
Ampicillin purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]
Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.
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J Antimicrob Chemother
Ampicillin-sulbactam against Acinetobacter baumannii infections: pharmacokinetic/pharmacodynamic appraisal of current susceptibility breakpoints and dosing recommendations. [Abstract]2024 Jul 20:dkae218. PMID: 39031073 -
J Antimicrob Chemother
Defining optimal sulbactam regimens for treatment of Acinetobacter baumannii pneumonia and impact of blaOXA-23 on efficacy. [Abstract]2024 Jul 13:dkae229. PMID: 38997215 -
Heliyon
Facilitation of Sclerotinia sclerotiorum infestation by aphid feeding behaviour is not affected by aphid resistance in oilseed rape. [Abstract]2024 Jun 6;10(11):e32429. PMID: 38933983 -
J Antimicrob Chemother
In vivo efficacy & resistance prevention of cefiderocol in combination with ceftazidime/avibactam, ampicillin/sulbactam or meropenem using human-simulated regimens versus Acinetobacter baumannii. [Abstract]2023 Apr 3;78(4):983-990. PMID: 36775993 -
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Naunyn Schmiedebergs Arch Pharmacol
5-aminosalicylic acid alleviates colitis and protects intestinal barrier function by modulating gut microbiota in mice. [Abstract]2025 Apr;398(4):3681-3695. PMID: 39352537 -
Vet Microbiol
Discovery of the tigecycline resistance gene cluster tmexCD3-toprJ1 in Pasteurella multocida strains isolated from pigs in China. [Abstract]2024 May:292:110046. PMID: 38471428 -
Infect Genet Evol
Polymyxin B combined with amikacin delays the resistance of Klebsiella pneumoniae to polymyxin B by modulating the expression of NlpE. [Abstract]2025 Sep:133:105780. PMID: 40480594 -
Protoplasma
Chemical, biological, morphological, and anatomical exploration of Tripleurospermum monticolum Born. (Asteraceae): A promising medicinal plant. [Abstract]2025 Nov 6. PMID: 41193839 -
Biomed Res Int
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]2018 Jul 2:2018:3579832. PMID: 30065936 -
Biochem Biophys Res Commun
Multi-omics approaches to explore the therapeutic mechanism for ginsenoside Rg1 against MASLD. [Abstract]2025 Jun 7:776:152161. PMID: 40527176 -
Vet Res Commun
Biological characterization of lipoic acid- and heme-dependent Escherichia coli small colony variants isolated from sheep in Xinjiang, China. [Abstract]2024 Dec;48(6):3859-3872. PMID: 39325108 -
Anim Dis
Pasteurella multocida capsular: lipopolysaccharide types D:L6 and A:L3 remain to be the main epidemic genotypes of pigs in China. [Abstract]2021;1(1):26. PMID: 34778886 -
Diagn Microbiol Infect Dis
2026 Feb;114(2):117181. PMID: 41205476 -
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Solvent & Solubility
H2O : 4.9 mg/mL (14.02 mM; ultrasonic and warming and adjust pH to 9 with NaOH and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Mice: Ampicillin is dissolved in normal saline. Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral common carotid artery occlusion for 40 min. Before transient forebrain ischemia, ampicillin (200 mg/kg, intraperitoneally [i.p.]) or penicillin G (6,000 U/kg or 20,000 U/kg, i.p.) was administered daily for 5 days. In the control animals, saline was administered at the same volume and time schedule[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7. [Content Brief]
[2]. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7(2):133-5. [Content Brief]
[3]. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.8620 mL | 14.3102 mL | 28.6205 mL | 71.5512 mL |
| 5 mM | 0.5724 mL | 2.8620 mL | 5.7241 mL | 14.3102 mL | |
| 10 mM | 0.2862 mL | 1.4310 mL | 2.8620 mL | 7.1551 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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