1. Anti-infection
  2. Bacterial

Ampicillin sodium (Synonyms: D-(-)-α-Aminobenzylpenicillin sodium salt)

Cat. No.: HY-B0522A Purity: 95.16%
Data Sheet SDS Handling Instructions

Ampicillin sodium is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

For research use only. We do not sell to patients.
Ampicillin sodium Chemical Structure

Ampicillin sodium Chemical Structure

CAS No. : 69-52-3

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Other Forms of Ampicillin sodium:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Ampicillin sodium is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

In Vitro

Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL[1].

In Vivo

Ampicillin is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig[1]. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood[2]. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia[3].

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01433757 University of Florida|Tyler's Hope for a Dystonia Cure, Inc DYT-1|Dystonia September 2011 Phase 1
NCT02427932 Stanford University|David Drover, MD Drug Metabolism During Pregnancy May 2015
NCT01138852 Attikon Hospital Surgical Site Infections July 2004 Phase 4
NCT00887276 University of Ulm|CAPNETZ Stiftung Community Acquired Pneumonia November 2008 Phase 4
NCT02007603 Medical University of Vienna Infection During Hemodialysis August 2013 Phase 3
NCT00952796 Kaohsiung Medical University Chung-Ho Memorial Hospital Intra-abdominal Infection January 2009 Phase 4
NCT00879190 Stanford University Chorioamnionitis May 2009 Phase 2|Phase 3
NCT00368537 Wyeth is now a wholly owned subsidiary of Pfizer Skin Diseases, Bacterial September 2006 Phase 4
NCT00630513 University of Bologna|St. Orsola Hospital Intra-Abdominal Infection January 2008 Phase 4
NCT00137007 Pfizer Pneumonia November 2003 Phase 4
NCT01189487 Pfizer Pneumonia, Bacterial October 2010 Phase 3
NCT00356148 Marmara University Breast Cancer October 2003 Phase 4
NCT00002052 University of Southern California|NIH AIDS Clinical Trials Information Service HIV Infections|Salmonella Infections
NCT01045902 Bayer Pneumonia, Aspiration|Lung Abscess February 2001 Phase 3
NCT01888822 University of Roma La Sapienza Cholelithiasis June 2013 Phase 4
NCT01678365 HaEmek Medical Center, Israel Complicated Appendicitis July 2008 Phase 4
NCT01793688 Pfizer Pneumonia|Lung Abscess|Peritonitis March 12, 2013
NCT01551394 PENTA Foundation|Chiesi Farmaceutici S.p.A. Sepsis September 2012 Phase 3
NCT01945450 Hadassah Medical Organization Endometritis January 2014
NCT00814905 United States Naval Medical Center, Portsmouth Chorioamnionitis June 2009
NCT01633294 Hospital de Santa Maria, Portugal Chorioamnionitis|Puerperal Endometritis|Neonatal Early Onset Sepsis|Neonatal Meningitis|Neonatal Pneumonia October 2008 Phase 2|Phase 3
NCT03060473 The University of Texas Medical Branch, Galveston Preterm Premature Rupture of Membranes (PPROM) February 23, 2017 Phase 3
NCT01312792 International Centre for Diarrhoeal Disease Research, Bangladesh|UNICEF Pneumonia August 2010
NCT01994993 Michael Cohen-Wolkowiez|The EMMES Corporation|Duke University Complicated Intra Abdominal Infections December 2013 Phase 2|Phase 3
NCT02477423 University of Chicago Premature Birth of Newborn|Enterocolitis, Necrotizing July 2015
NCT02819570 Western Galilee Hospital-Nahariya Premature Rupture of Membrane November 2015 Phase 4
NCT02865564 University Medical Centre Ljubljana|University of Ljubljana Gastrointestinal Diseases|Colic September 2016
NCT00195923 Children's Mercy Hospital Kansas City Perforated Appendicitis April 2005 Phase 4
NCT02960919 Save the Children|University of Washington|University of North Carolina, Project Lilongwe Medical Relief Trust Fund|Kamuzu Central Hospital|College of Medicine at the University of Malawi Pneumonia October 2016
NCT02384200 University of California, San Diego|Mayo Clinic|University of British Columbia|The Cleveland Clinic|Duke University|Ohio State University|Dartmouth-Hitchcock Medical Center|Vanderbilt University|New York University Nephrolithiasis|Urinary Tract Infections March 2015 Phase 4
NCT00462020 Children's Mercy Hospital Kansas City Perforated Appendicitis March 2007
NCT02829060 University of California, San Diego Nephrolithiasis|Urinary Tract Infection (UTI)|Sepsis January 2016
NCT02784821 University of Florida Enterocolitis, Necrotizing|Bacteremia|Bronchopulmonary Dysplasia January 2017 Phase 2
NCT00021671 National Institute of Allergy and Infectious Diseases (NIAID)|National Institute of Mental Health (NIMH)|National Institute on Drug Abuse (NIDA) HIV Infections Phase 3
NCT00491426 Duke University|Pediatric Pharmacology Research Units Network Infection January 2006 Phase 1
NCT01433757 University of Florida|Tyler's Hope for a Dystonia Cure, Inc DYT-1|Dystonia September 2011 Phase 1
NCT02427932 Stanford University|David Drover, MD Drug Metabolism During Pregnancy May 2015
NCT01138852 Attikon Hospital Surgical Site Infections July 2004 Phase 4
NCT00887276 University of Ulm|CAPNETZ Stiftung Community Acquired Pneumonia November 2008 Phase 4
NCT02007603 Medical University of Vienna Infection During Hemodialysis August 2013 Phase 3
NCT00952796 Kaohsiung Medical University Chung-Ho Memorial Hospital Intra-abdominal Infection January 2009 Phase 4
NCT00879190 Stanford University Chorioamnionitis May 2009 Phase 2|Phase 3
NCT00368537 Wyeth is now a wholly owned subsidiary of Pfizer Skin Diseases, Bacterial September 2006 Phase 4
NCT00630513 University of Bologna|St. Orsola Hospital Intra-Abdominal Infection January 2008 Phase 4
NCT00137007 Pfizer Pneumonia November 2003 Phase 4
NCT01189487 Pfizer Pneumonia, Bacterial October 2010 Phase 3
NCT00356148 Marmara University Breast Cancer October 2003 Phase 4
NCT00002052 University of Southern California|NIH AIDS Clinical Trials Information Service HIV Infections|Salmonella Infections
NCT01045902 Bayer Pneumonia, Aspiration|Lung Abscess February 2001 Phase 3
NCT01888822 University of Roma La Sapienza Cholelithiasis June 2013 Phase 4
NCT01678365 HaEmek Medical Center, Israel Complicated Appendicitis July 2008 Phase 4
NCT01793688 Pfizer Pneumonia|Lung Abscess|Peritonitis March 12, 2013
NCT01551394 PENTA Foundation|Chiesi Farmaceutici S.p.A. Sepsis September 2012 Phase 3
NCT01945450 Hadassah Medical Organization Endometritis January 2014
NCT00814905 United States Naval Medical Center, Portsmouth Chorioamnionitis June 2009
NCT01633294 Hospital de Santa Maria, Portugal Chorioamnionitis|Puerperal Endometritis|Neonatal Early Onset Sepsis|Neonatal Meningitis|Neonatal Pneumonia October 2008 Phase 2|Phase 3
NCT03060473 The University of Texas Medical Branch, Galveston Preterm Premature Rupture of Membranes (PPROM) February 23, 2017 Phase 3
NCT01312792 International Centre for Diarrhoeal Disease Research, Bangladesh|UNICEF Pneumonia August 2010
NCT01994993 Michael Cohen-Wolkowiez|The EMMES Corporation|Duke University Complicated Intra Abdominal Infections December 2013 Phase 2|Phase 3
NCT02477423 University of Chicago Premature Birth of Newborn|Enterocolitis, Necrotizing July 2015
NCT02819570 Western Galilee Hospital-Nahariya Premature Rupture of Membrane November 2015 Phase 4
NCT02865564 University Medical Centre Ljubljana|University of Ljubljana Gastrointestinal Diseases|Colic September 2016
NCT00195923 Children's Mercy Hospital Kansas City Perforated Appendicitis April 2005 Phase 4
NCT02960919 Save the Children|University of Washington|University of North Carolina, Project Lilongwe Medical Relief Trust Fund|Kamuzu Central Hospital|College of Medicine at the University of Malawi Pneumonia October 2016
NCT02384200 University of California, San Diego|Mayo Clinic|University of British Columbia|The Cleveland Clinic|Duke University|Ohio State University|Dartmouth-Hitchcock Medical Center|Vanderbilt University|New York University Nephrolithiasis|Urinary Tract Infections March 2015 Phase 4
NCT00462020 Children's Mercy Hospital Kansas City Perforated Appendicitis March 2007
NCT02829060 University of California, San Diego Nephrolithiasis|Urinary Tract Infection (UTI)|Sepsis January 2016
NCT02784821 University of Florida Enterocolitis, Necrotizing|Bacteremia|Bronchopulmonary Dysplasia January 2017 Phase 2
NCT00021671 National Institute of Allergy and Infectious Diseases (NIAID)|National Institute of Mental Health (NIMH)|National Institute on Drug Abuse (NIDA) HIV Infections Phase 3
NCT00491426 Duke University|Pediatric Pharmacology Research Units Network Infection January 2006 Phase 1
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References
Animal Administration
[3]

Mouse: Ampicillin is dissolved in normal saline. Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral common carotid artery occlusion for 40 min. Before transient forebrain ischemia, ampicillin (200 mg/kg, intraperitoneally [i.p.]) or penicillin G (6,000 U/kg or 20,000 U/kg, i.p.) was administered daily for 5 days. In the control animals, saline was administered at the same volume and time schedule[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

371.39

Formula

C₁₆H₁₈N₃NaO₄S

CAS No.

69-52-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 200 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Ampicillin sodium
Cat. No.:
HY-B0522A
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