1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Ampicillin sodium

Ampicillin sodium (Synonyms: D-(-)-α-Aminobenzylpenicillin sodium salt)

Cat. No.: HY-B0522A Purity: >98.0%
Handling Instructions

Ampicillin sodium (D-(-)-α-Aminobenzylpenicillin sodium salt) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria.

For research use only. We do not sell to patients.

Ampicillin sodium Chemical Structure

Ampicillin sodium Chemical Structure

CAS No. : 69-52-3

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Customer Review

Based on 4 publication(s) in Google Scholar

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Description

Ampicillin sodium (D-(-)-α-Aminobenzylpenicillin sodium salt) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria[1].

IC50 & Target

Bacterial[1]

In Vitro

Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ampicillin is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig[1]. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood[2]. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

371.39

Formula

C₁₆H₁₈N₃NaO₄S

CAS No.

69-52-3

SMILES

O=C([[email protected]@H]1N(C2=O)[[email protected]]([[email protected]@H]2NC([[email protected]@H](C3=CC=CC=C3)N)=O)([H])SC1(C)C)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 200 mg/mL (538.52 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6926 mL 13.4629 mL 26.9259 mL
5 mM 0.5385 mL 2.6926 mL 5.3852 mL
10 mM 0.2693 mL 1.3463 mL 2.6926 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[3]

Mice: Ampicillin is dissolved in normal saline. Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral common carotid artery occlusion for 40 min. Before transient forebrain ischemia, ampicillin (200 mg/kg, intraperitoneally [i.p.]) or penicillin G (6,000 U/kg or 20,000 U/kg, i.p.) was administered daily for 5 days. In the control animals, saline was administered at the same volume and time schedule[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: >98.0%

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Keywords:

AmpicillinD-(-)-α-AminobenzylpenicillinBacterialAntibioticInhibitorinhibitorinhibit

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Ampicillin sodium
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