1. Anti-infection
    Membrane Transporter/Ion Channel
  2. Bacterial
    Calcium Channel

Neomycin sulfate 

Cat. No.: HY-B0470 Purity: >98.0%
Handling Instructions

Neomycin sulfate is an aminoglycoside antibiotic and calcium channel inhibitor.

For research use only. We do not sell to patients.
Neomycin sulfate Chemical Structure

Neomycin sulfate Chemical Structure

CAS No. : 1405-10-3

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Neomycin sulfate is an aminoglycoside antibiotic and calcium channel inhibitor.

In Vitro

Neomycin inhibits thrombin-stimulated release of inositol 1,4,5-trisphosphate (IP3), by selectively binding PIP2, but does not inhibit 32P incorporation into PI or initiation of DNA synthesis[1]. Neomycin (10 μM-1 mM) induces considerable release of [3H]arachidonic acid from phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine in saponin-permeabilized human platelets prelabeled with [3H]arachidonic acid. Moreover, neomycin enhances arachidonic acid release induced by thrombin. Addition of neomycin (100 μM) to 45Ca2+-preloaded platelets elicits 45Ca2+ mobilizatioin from intracellular stores[2]. Neomycin (0-10 mM) inhibits guanosine 5'-[gamma-thio]triphosphate-stimulated PLD activity in digitonin-permeabilized NG108-15 cells in a concentration-dependent manner (50% inhibition at 100 μM). Neomycin similarly inhibits PLD activity present in rat brain membranes and assayed in vitro with [3H]phosphatidylcholine as substrate (50% inhibition at 65 μM)[3]. Neomycin (5 mM) causes reversible reductions in the level of intracellular Ca2+, but PtdIns(4,5)P2 is not required for the channel activity[4].

References
Molecular Weight

908.88

Formula

C₂₃H₅₂N₆O₂₅S₃

CAS No.

1405-10-3

SMILES

O[[email protected]]1[[email protected]](O)[[email protected]@H](N)[[email protected]@H](O[[email protected]@H]2[[email protected]@H](N)C[[email protected]@H](N)[[email protected]](O)[[email protected]]2O[[email protected]@H]3O[[email protected]](CO)[[email protected]@H](O[[email protected]]4O[[email protected]@H](CN)[[email protected]@H](O)[[email protected]](O)[[email protected]]4N)[[email protected]]3O)O[[email protected]@H]1CN.[3H2SO4]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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Product Name:
Neomycin sulfate
Cat. No.:
HY-B0470
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