1. Anti-infection
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Bacterial
    Calcium Channel
  3. Neomycin sulfate

Neomycin sulfate 

Cat. No.: HY-B0470 Purity: >98.0%
Handling Instructions

Neomycin sulfate is an aminoglycoside antibiotic used for preventing or treating bacterial infections.

For research use only. We do not sell to patients.

Neomycin sulfate Chemical Structure

Neomycin sulfate Chemical Structure

CAS No. : 1405-10-3

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Based on 1 publication(s) in Google Scholar

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Description

Neomycin sulfate is an aminoglycoside antibiotic used for preventing or treating bacterial infections.

In Vitro

Neomycin inhibits thrombin-stimulated release of inositol 1,4,5-trisphosphate (IP3), by selectively binding PIP2, but does not inhibit 32P incorporation into PI or initiation of DNA synthesis[1]. Neomycin (10 μM-1 mM) induces considerable release of [3H]arachidonic acid from phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine in saponin-permeabilized human platelets prelabeled with [3H]arachidonic acid. Moreover, neomycin enhances arachidonic acid release induced by thrombin. Addition of neomycin (100 μM) to 45Ca2+-preloaded platelets elicits 45Ca2+ mobilizatioin from intracellular stores[2]. Neomycin (0-10 mM) inhibits guanosine 5'-[gamma-thio]triphosphate-stimulated PLD activity in digitonin-permeabilized NG108-15 cells in a concentration-dependent manner (50% inhibition at 100 μM). Neomycin similarly inhibits PLD activity present in rat brain membranes and assayed in vitro with [3H]phosphatidylcholine as substrate (50% inhibition at 65 μM)[3]. Neomycin (5 mM) causes reversible reductions in the level of intracellular Ca2+, but PtdIns(4,5)P2 is not required for the channel activity[4].

Molecular Weight

908.88

Formula

C₂₃H₅₂N₆O₂₅S₃

CAS No.

1405-10-3

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 31 mg/mL (34.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1003 mL 5.5013 mL 11.0026 mL
5 mM 0.2201 mL 1.1003 mL 2.2005 mL
10 mM 0.1100 mL 0.5501 mL 1.1003 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

NeomycinBacterialCalcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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Neomycin sulfate
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