1. Anti-infection Metabolic Enzyme/Protease
  2. Bacterial Antibiotic Phospholipase
  3. Neomycin sulfate

Neomycin sulfate 

Cat. No.: HY-B0470 Purity: ≥98.0%
COA Handling Instructions

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis.

For research use only. We do not sell to patients.

Neomycin sulfate Chemical Structure

Neomycin sulfate Chemical Structure

CAS No. : 1405-10-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 33 In-stock
Solution
10 mM * 1 mL in Water USD 33 In-stock
Solid
500 mg USD 30 In-stock
1 g USD 35 In-stock
5 g USD 52 In-stock
10 g USD 60 In-stock
50 g   Get quote  

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Customer Review

Based on 22 publication(s) in Google Scholar

Other Forms of Neomycin sulfate:

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Description

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis[1][2].

IC50 & Target

Aminoglycoside

 

In Vitro

Neomycin is effective against most gram-negative organisms except Pseudomonas aeruginosa and anaerobic bacteria. Its activity against gram-positive microorganisms is more or less limited to staphylococci, but bacterial resistance supervenes after prolonged use[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

908.88

Formula

C23H52N6O25S3

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]1[C@H](O)[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)O[C@@H]1CN.[3H2SO4]

Structure Classification
Initial Source

Micromonospora species

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (275.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1003 mL 5.5013 mL 11.0026 mL
5 mM 0.2201 mL 1.1003 mL 2.2005 mL
10 mM 0.1100 mL 0.5501 mL 1.1003 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (55.01 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Neomycin sulfate
Cat. No.:
HY-B0470
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