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Neomycin sulfate

73 Cited Publications
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Based on 73 publication(s) in Google Scholar

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca2+ release, MgATP-dependent Ca2+ uptake, and electrical excitation-evoked skeletal muscle Ca2+ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer.

For research use only. We do not sell to patients.

  • Purity: 99.86%
  • CAS No.: 1405-10-3
  • Formula: C23H52N6O25S3
  • Molecular Weight:908.88
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Neomycin sulfate Chemical Structure
    Neomycin sulfate Chemical Structure
  • Experimental Validation Results for Neomycin sulfate
  • Experimental Validation Results for Neomycin sulfate
  • Experimental Validation Results for Neomycin sulfate
  • Experimental Validation Results for Neomycin sulfate
CAS No.: 1405-10-3
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  • Neomycin sulfate Chemical Structure
    Neomycin sulfate Chemical Structure
    1/16
  • 1/16

    Neomycin sulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(16):e2415041. [Abstract]

    Customer Validation
     ABR thresholds in each group. The statistical differences were analyzed between Neomycin (100 mg/kg once daily for 14 days, ip) + PO group and Neomycin group.

  • 1/16

    Neomycin sulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(16):e2415041. [Abstract]

    Customer Validation
     Effects of different levels of UA on HCs in the apical, middle, and basal turns after Neomycin (0.5 mM) treatment for 24 h.

  • 1/16

    Neomycin sulfate purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2023 Dec;15(2):2282790. [Abstract]

    Customer Validation
     Depletion of CD8+ T cells in ABX-treated B16-F0 tumor-bearing mice dampened the antitumor effect of butyrate combined with anti-PD-1 (Figure 4b–e). Decreased serum IFN-γ and TNF-α production during the depletion of CD8+ T cells was also observed. ABX：an antibiotic cocktail of 0.5 g/L Vancomycin, 1 g/L Metronidazole, 1 g/L Neomycin and 1 g/L Ampicillin.

  • 1/16

    Neomycin sulfate purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2023 Dec;15(2):2249143. [Abstract]

    Customer Validation
     Targeted metabolomics analysis of gut microbial metabolites (AA, PA, and BA) in colon contents (feces) and serum from mice with or without ABX treatment (n = 6 per group). ABX: an antibiotic cocktail of 0.5 g/L Vancomycin, 1 g/L Metronidazole,1 g/L Neomycin and 1 g/L Ampicillin

  • Neomycin sulfate