1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Kanamycin sulfate

Kanamycin sulfate (Synonyms: Kanamycin A monosulfate)

Cat. No.: HY-16566A Purity: >98.0%
Handling Instructions

Kanamycin sulfate is an aminoglycoside bacteriocidal antibiotic which acts by binding to the bacterial 30S ribosomes.

For research use only. We do not sell to patients.

Kanamycin sulfate Chemical Structure

Kanamycin sulfate Chemical Structure

CAS No. : 25389-94-0

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10 mM * 1  mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
200 mg USD 50 In-stock
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5 g USD 80 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Kanamycin sulfate is an aminoglycoside bacteriocidal antibiotic which acts by binding to the bacterial 30S ribosomes.

In Vitro

Kanamycin sulfate at the concentration above 0.0025% has a significant inhibition on the growth of B. bifidum and has no influence on the other four probiotics at incubation 12 h or 24 h. The optimum selective concentration of kanamycin sulfate in MRS media is 0.005% for selective enumeration of B.bifidum[3].

In Vivo

The neurons damage of the DCN caused by kanamycin (500 mg/kg/day) is reversible and autophagy is upregulated in the neurotoxic course of kanamycin on DCN through JNK1-mediated phosphorylation of Bcl-2 pathway in rats. The serum BUN and Cr levels are both increased at the 1st day after the period of kanamycin administration. The neurons expressing LC3 are increased at 1, 7 and 14 days after kanamycin administration in comparison to the control group. Kanamycin treatment results in the increase of autophagy in a time-dependent manner[1]. Kanamycin sulfate (5 mg/kg) and sodium ampicillin (10 mg/kg) administered intramuscularly (i.m.) separately, and then together, to five pony mares, and the ampicillin concentration exceeds 5 mg/mL in inflamed synovial fluid for some 2.5 h after injection, and kanamycin sulfate concentration exceeds 2 mg/mL for 7 h in the pony[2].

Clinical Trial
Molecular Weight

582.58

Formula

C₁₈H₃₈N₄O₁₅S

CAS No.

25389-94-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (171.65 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7165 mL 8.5825 mL 17.1650 mL
5 mM 0.3433 mL 1.7165 mL 3.4330 mL
10 mM 0.1717 mL 0.8583 mL 1.7165 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Sixty-six male Sprague-Dawley rats (initial body weight 125-150 g, 5-6 weeks old) have free access to water and a regular diet, and are allowed 1 week of acclimation before the first treatment. The animals are divided randomly into one control group and seven experimental groups. Control group rats (n=10) are injected subcutaneously with an equal volume of vehicle (0.9% saline) for 10 days as those in the groups of kanamycin treatment, but without kanamycin. The experimental groups (n=56, 8 for each group: 1, 7, 14, 28, 56, 70 and 140 days after kanamycin administration, respectively) receive 500 mg of kanamycin sulfate/kg/day by subcutaneous injection for 10 days. The animal body weight is monitored every day and the injection dosage of kanamycin is adjusted accordingly. Auditory thresholds are tested by ABR. The tests are taken twice for each animal, first prior to the beginning of administration and then at different observing time points after kanamycin treatment. Details for the ABR measurement is described elsewhere.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: >98.0%

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Keywords:

KanamycinKanamycin A monosulfateBacterialAntibioticInhibitorinhibitorinhibit

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Kanamycin sulfate
Cat. No.:
HY-16566A
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