Amprolium hydrochloride
Based on 1 Customer Validation
Amprolium hydrochloride is an anti-parasitic drug that's kind of taken orally, and it acts as an antagonist to thiamine in intestinal absorption.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.79%
- CAS. Nr.: 137-88-2
- Formel: C14H20Cl2N4
- Molecular Weight:315.24
-
Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-B0937AR
Amprolium hydrochloride (Standard) -
HY-B0511
Biotin -
HY-B0166
L-Ascorbic acid -
HY-N0150
Monensin sodium -
HY-16637
Folic acid -
HY-B1342
Vitamin A -
HY-32351A
Calcifediol monohydrate -
HY-N0684
Vitamin K1 -
HY-B0511R
Biotin (Standard) -
HY-B2156
Menaquinone-4 -
HY-B0166G
L-Ascorbic acid (GMP) -
HY-B0166R
L-Ascorbic acid (Standard)
Alle Parasite Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
IC50 & Target
|
Coccidia |
In Vivo
Amprolium hydrochloride (8 mg-2 g, taken orally or injected subcutaneously, daily, for 4-34 days) exerts an antagonistic effect with thiamine primarily at the level of the intestinal epithelial cells, impacting thiamine absorption. Once administered directly bypassing the gut, it does not significantly affect thiamine's entry into other tissue cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rabbits of white and California white breeds[1]
-
Dosage:1 g/L; daily; 7 days
-
Administration:Oral
-
Result:Had a good effect when used as preventive measures or combined with other antibody-resistant drugs.
-
Animal Model:Rat with lack of thiamine[2]
-
Dosage:8 mg, daily, 4 days
-
Administration:Oral
-
Result:prevented the normal accumulation of thiamine in the tissue, and the antagonistic effect on the absorption of thumine was only existed at the intestinal level.
-
Animal Model:Rat with lack of thiamine[2]
-
Dosage:2 g, daily, 34 days
-
Administration:Subcutaneous injection (s.c.)
-
Result:Did not prevent the deposition of thumine in the organs, and its level was close to the level reached by separate injection of thiamine.
Chemical Information
-
CAS. Nr. 137-88-2
-
Appearance Solid
-
Molecular Weight 315.24
-
Formel C14H20Cl2N4
-
Color White to off-white
-
SMILES
CC1=CC=CC=[N+]1CC2=CN=C(CCC)N=C2N.[Cl-].Cl
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
H2O : ≥ 200 mg/mL (634.44 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (317.22 mM); Clear solution; Need ultrasonic
Reinheit & Dokumentation
-
Data Sheet (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Kennedy O Ogolla, et al. Efficacy of Sulphachloropyrazine, Amprolium Hydrochloride, Trimethoprim-Sulphamethoxazole, and Diclazuril against Experimental and Natural Rabbit Coccidiosis. J Vet Med. 2018 Oct 23:2018:5402469. [Content Brief]
[2]. G Rindi, et al. Action of Amprolium on the thiamine content of rat tissues. J Nutr. 1966 Jun;89(2):197-202. [Content Brief]
[3]. Iqbal A, et al. Antiparasitic efficacy of Artemisia absinthium, toltrazuril and amprolium against intestinal coccidiosis in goats. J Parasit Dis. 2013 Apr;37(1):88-93. [Content Brief]
[4]. Lindsay DS, et al. Effects of sulfadiazine and amprolium on Neospora caninum (Protozoa: Apicomplexa) infections in mice. J Parasitol. 1990 Apr;76(2):177-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.1722 mL | 15.8609 mL | 31.7219 mL | 79.3047 mL |
| 5 mM | 0.6344 mL | 3.1722 mL | 6.3444 mL | 15.8609 mL | |
| 10 mM | 0.3172 mL | 1.5861 mL | 3.1722 mL | 7.9305 mL | |
| 15 mM | 0.2115 mL | 1.0574 mL | 2.1148 mL | 5.2870 mL | |
| 20 mM | 0.1586 mL | 0.7930 mL | 1.5861 mL | 3.9652 mL | |
| 25 mM | 0.1269 mL | 0.6344 mL | 1.2689 mL | 3.1722 mL | |
| 30 mM | 0.1057 mL | 0.5287 mL | 1.0574 mL | 2.6435 mL | |
| 40 mM | 0.0793 mL | 0.3965 mL | 0.7930 mL | 1.9826 mL | |
| 50 mM | 0.0634 mL | 0.3172 mL | 0.6344 mL | 1.5861 mL | |
| 60 mM | 0.0529 mL | 0.2643 mL | 0.5287 mL | 1.3217 mL | |
| 80 mM | 0.0397 mL | 0.1983 mL | 0.3965 mL | 0.9913 mL | |
| 100 mM | 0.0317 mL | 0.1586 mL | 0.3172 mL | 0.7930 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Amprolium hydrochloride Related Classifications
HY-B0937A Related Classifications
Powered by Bioz