Diclazuril-d4
Based on 1 Customer Validation
Diclazuril-d4 is deuterium labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.
For research use only. We do not sell to patients.
- Purity: 97.62%
- CAS No.: 1632495-80-7
- Formula: C17H5D4Cl3N4O2
- Molecular Weight:411.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Coccidia |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1632495-80-7
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Unlabeled Cas 101831-37-2
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Appearance Solid
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Molecular Weight 411.66
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Formula C17H5D4Cl3N4O2
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Color White to yellow
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SMILES
O=C1N(N=CC(N1)=O)C2=CC(Cl)=C(C(Cl)=C2)C(C3=C([2H])C([2H])=C(C([2H])=C3[2H])Cl)C#N
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Synonyms
R-64433-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (60.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (399 KB)
- English - EN (399 KB)
- Français - FR (399 KB)
- Deutsch - DE (399 KB)
- Norwegian - NO (399 KB)
- Español - ES (399 KB)
- Swedish - SV (399 KB)
- Italian - IT (399 KB)
- Korean - KR (399 KB)
- Portuguese - PT (399 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Diaferia, M., et al., Efficacy of toltrazuril 5 % suspension (Baycox(R), Bayer) and diclazuril (Vecoxan(R), Janssen-Cilag) in the control of Eimeria spp. in lambs. Parasitol Res, 2013. 112 Suppl 1: p. 163-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4292 mL | 12.1459 mL | 24.2919 mL | 60.7297 mL |
| 5 mM | 0.4858 mL | 2.4292 mL | 4.8584 mL | 12.1459 mL | |
| 10 mM | 0.2429 mL | 1.2146 mL | 2.4292 mL | 6.0730 mL | |
| 15 mM | 0.1619 mL | 0.8097 mL | 1.6195 mL | 4.0486 mL | |
| 20 mM | 0.1215 mL | 0.6073 mL | 1.2146 mL | 3.0365 mL | |
| 25 mM | 0.0972 mL | 0.4858 mL | 0.9717 mL | 2.4292 mL | |
| 30 mM | 0.0810 mL | 0.4049 mL | 0.8097 mL | 2.0243 mL | |
| 40 mM | 0.0607 mL | 0.3036 mL | 0.6073 mL | 1.5182 mL | |
| 50 mM | 0.0486 mL | 0.2429 mL | 0.4858 mL | 1.2146 mL | |
| 60 mM | 0.0405 mL | 0.2024 mL | 0.4049 mL | 1.0122 mL |
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