1. Anti-infection
  2. Parasite

PK-11195 (Synonyms: RP-52028)

Cat. No.: HY-19567
Handling Instructions

PK-11195 is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.

For research use only. We do not sell to patients.

PK-11195 Chemical Structure

PK-11195 Chemical Structure

CAS No. : 85532-75-8

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

PK-11195 is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.

IC50 & Target

IC50: 14.2 μM (L. amazonensis), 8.2 μM (L. major), 3.5 μM (L. braziliensis)[1].

In Vitro

Median IC50 values for PK-11195 are 14.2 μM for L. amazonensis, 8.2 μM for L. major, and 3.5 μM for L. braziliensis. The selective index value for L. amazonensis is 13.7, indicating the safety of PK-11195 for future testing in mammals. Time-and dose-dependent reductions in the percentage of infected macrophages, the number of parasites per infected macrophage, and the number of viable intracellular parasites are observed. Electron microscopy reveals some morphological alterations suggestive of autophagy. Interestingly, MCP-1 and superoxide levels are reduced in L. amazonensis-infected macrophages treated with PK-11195[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8340 mL 14.1699 mL 28.3399 mL
5 mM 0.5668 mL 2.8340 mL 5.6680 mL
10 mM 0.2834 mL 1.4170 mL 2.8340 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

352.86

Formula

C₂₁H₂₁ClN₂O

CAS No.

85532-75-8

SMILES

O=C(N(C(CC)C)C)C1=CC2=CC=CC=C2C(C3=CC=CC=C3Cl)=N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
PK-11195
Cat. No.:
HY-19567
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PK-11195

Cat. No.: HY-19567