Structure activity studies of a novel cytotoxic benzodiazepine

  • Bioorg Med Chem Lett. 2003 Oct 6;13(19):3327-30. doi: 10.1016/s0960-894x(03)00683-8.
Anthony Boitano  1 ,  Cory D Emal ,  Francesco Leonetti ,  Neal B Blatt ,  Thomas A Dineen ,  Jonathan A Ellman ,  William R Roush ,  Anthony W Opipari ,  Gary D Glick
Affiliations
  • 1. Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109-1055, USA.
PMID: 12951119 DOI: 10.1016/s0960-894x(03)00683-8
Abstract

Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. The results of these experiments have defined the structural elements of this new cytotoxic agent required for activity.