1201652-50-7
1201652-50-7
Chemical Structure
Retro-2
- CAS No.: 1201652-50-7
- Formula:C19H16N2OS
- Molecular Weight:320.41
IUPAC Name: (E)-2-(((5-methylthiophen-2-yl)methylene)amino)-N-phenylbenzamide
InChIKey: QEGJLRIARJEIPG-DEDYPNTBSA-N
SMILES: O=C(NC1=CC=CC=C1)C2=CC=CC=C2/N=C/C3=CC=C(C)S3
Biological Activity: Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Retro-2 | 98.0% | Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy. | ||||||||||||||||||||
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References
- [1]. Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42. [Content Brief]
- [2]. Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464. [Content Brief]
- [3]. Olena Shtanko, et al. Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection. Antiviral Res. 2018 Jan;149:154-163. [Content Brief]
