1554691-37-0
1554691-37-0
Chemical Structure
LASSBio-1736
- CAS No.: 1554691-37-0
- Formula:C16H11Cl2F3N4O2
- Molecular Weight:419.19
InChIKey: SSHIDDOGLXOLSC-GZIVZEMBSA-N
SMILES: O=C(NNC(C1=CC=C(Cl)C=C1Cl)=O)N/N=C/C2=CC=C(C(F)(F)F)C=C2
Biological Activity: LASSBio-1736 is a Cysteine protease inhibitor and antimalarial agent. LASSBio-1736 targets the promastigote form of Leishmania major. LASSBio-1736 can be used in the research of leishmaniasis[1][2][3].
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LASSBio-1736 | LASSBio-1736 is a Cysteine protease inhibitor and antimalarial agent. LASSBio-1736 targets the promastigote form of Leishmania major. LASSBio-1736 can be used in the research of leishmaniasis. | |||||||||||||||||||||
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References
- [1]. Moraes BS, et al. Leishmanicidal candidate LASSBio-1736, a cysteine protease inhibitor with favorable pharmacokinetics: low clearance and good distribution. Xenobiotica. 2018 Dec;48(12):1258-1267. [Content Brief]
- [2]. de Queiroz AC, et al. Pre-clinical evaluation of LASSBio-1491: From in vitro pharmacokinetic study to in vivo leishmanicidal activity. PLoS One. 2022 Jun 6;17(6):e0269447. [Content Brief]
- [3]. Moraes BKS, et al. Simple HPLC-UV for the quantification of a new leishmanicidal candidate (E)-1-4(trifluoromethyl) benzylidene)-5-(2-4-dichlorozoyl) carbonylhydrazine (LASSBio-1736) in rat plasma for pharmacokinetics assessment. Biomed Chromatogr. 2016 Jul;30(7):1029-1035. [Content Brief]
Keywords
