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  4. Naringenin 4',7-dimethyl ether

Naringenin 4',7-dimethyl ether, Naringenin (HY-N0100) derivative is an anti-seizure agent. Naringenin 4',7-dimethyl ether attenuates pentylenetetrazole-induced seizures in larval zebrafish and reduces seizures in the mouse 6-Hz psychomotor seizure model. Naringenin 4',7-dimethyl ether can be used for the research of epilepsy.

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Naringenin 4',7-dimethyl ether

Naringenin 4',7-dimethyl ether Chemical Structure

CAS No. : 102101-05-3

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Description

Naringenin 4',7-dimethyl ether, Naringenin (HY-N0100) derivative is an anti-seizure agent. Naringenin 4',7-dimethyl ether attenuates pentylenetetrazole-induced seizures in larval zebrafish and reduces seizures in the mouse 6-Hz psychomotor seizure model. Naringenin 4',7-dimethyl ether can be used for the research of epilepsy[1].

In Vivo

Naringenin 4′,7-dimethyl ether (Compound NRG-DM) (12.5 μM; 1 h) potently attenuates PTZ-induced seizures in Danio rerio larvae, and nearly eliminating epileptiform brain activity[1].
Naringenin 4′,7-dimethyl ether (2-25 mg/kg; i.p.; single injection 30 minutes prior to electrical stimulation) protects mice against 6-Hz psychomotor seizures, with complete protection at 6.25 mg/kg and significant reduction in seizure duration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AB strain (7 days post-fertilization larvae)[1]
Dosage: 3.13 μM; 6.25 μM; 12.5 μM
Administration: 1 h
Result: Reduced PTZ-induced locomotor activity of PTZ control levels at 12.5 μM.
Significantly decreased the percentage of larvae with epileptiform activity at12.5 μM.
Drastically lowered the number and cumulative duration of PTZ-induced epileptiform events at 12.5 μM.
Achieved a mean whole body concentration of 279.4 ng/mg with uptake 340-fold higher than non-methylated naringenin at 12.5 μM.
Molecular Weight

300.31

Formula

C17H16O5
CAS No.
SMILES

O=C1C2=C(OC(C1)C3=CC=C(C=C3)OC)C=C(OC)C=C2O
Structure Classification
Initial Source
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Naringenin 4',7-dimethyl ether Related Classifications

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Keywords:

Naringenin 4',7-dimethyl ether102101-05-3Drug DerivativeDrug derivativelarval zebrafishmouse 6-Hz psychomotor seizure modelmouse timed i.v. pentylenetetrazole seizure modelepileptiform brain activityPTZ-induced seizurespentylenetetrazole-induced seizuresPTZ-induced deathepilepsy6-Hz psychomotor seizureszebrafish larvaeInhibitorinhibitorinhibit

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Naringenin 4',7-dimethyl ether
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HY-N18014
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