Naringenin 4',7-dimethyl ether
Naringenin 4',7-dimethyl ether, Naringenin (HY-N0100) derivative is an anti-seizure agent. Naringenin 4',7-dimethyl ether attenuates pentylenetetrazole-induced seizures in larval zebrafish and reduces seizures in the mouse 6-Hz psychomotor seizure model. Naringenin 4',7-dimethyl ether can be used for the research of epilepsy. Naringenin 4',7-dimethyl ether is an active agent against Leishmania mexicana (17.8 µM) and Trypanosoma brucei (17.5 µM).
For research use only. We do not sell to patients.
- CAS No.: 102101-05-3
- Formula: C17H16O5
- Molecular Weight:300.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Leishmania |
Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SMMC-7721 | IC50 |
200 μg/mL
Compound: 5-hydroxy-4',7-dimethoxy-dihydroflavone
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Cytotoxicity against human SMMC7721 cells by MTT assay
Cytotoxicity against human SMMC7721 cells by MTT assay
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[PMID: 14695795] |
Naringenin 4′,7-dimethyl ether (2-25 mg/kg; i.p.; single injection 30 minutes prior to electrical stimulation) protects mice against 6-Hz psychomotor seizures, with complete protection at 6.25 mg/kg and significant reduction in seizure duration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:AB strain (7 days post-fertilization larvae)[1]
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Dosage:3.13 μM; 6.25 μM; 12.5 μM
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Administration:1 h
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Result:Reduced PTZ-induced locomotor activity of PTZ control levels at 12.5 μM.
Significantly decreased the percentage of larvae with epileptiform activity at12.5 μM.
Drastically lowered the number and cumulative duration of PTZ-induced epileptiform events at 12.5 μM.
Achieved a mean whole body concentration of 279.4 ng/mg with uptake 340-fold higher than non-methylated naringenin at 12.5 μM.
Chemical Information
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CAS No. 102101-05-3
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Molecular Weight 300.31
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Formula C17H16O5
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SMILES
O=C1C2=C(OC(C1)C3=CC=C(C=C3)OC)C=C(OC)C=C2O
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Synonyms
NRG-DM
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Copmans D, et al. Methylated flavonoids as anti-seizure agents: Naringenin 4',7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models. Neurochem Int. 2018;112:124-133. [Content Brief]
[2]. Alotaibi A, Ebiloma GU, Williams R, et al. Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana. Molecules. 2021;26(13):3912. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Naringenin 4',7-dimethyl ether Related Classifications
HY-N18014 Related Classifications
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- Naringenin 4',7-dimethyl ether
- 102101-05-3
- NRG-DM
- Drug Derivative
- Parasite
- larval zebrafish
- mouse 6-Hz psychomotor seizure model
- mouse timed i.v. pentylenetetrazole seizure model
- epileptiform brain activity
- PTZ-induced seizures
- pentylenetetrazole-induced seizures
- PTZ-induced death
- epilepsy
- 6-Hz psychomotor seizures
- zebrafish larvae
- Inhibitor
- inhibitor
- inhibit