102101-05-3
Chemical Structure
Naringenin 4',7-dimethyl ether
Synonym(s): NRG-DM
- CAS No.: 102101-05-3
- Formula:C17H16O5
- Molecular Weight:300.31
InChIKey: CKEXCBVNKRHAMX-UHFFFAOYSA-N
SMILES: O=C1C2=C(OC(C1)C3=CC=C(C=C3)OC)C=C(OC)C=C2O
Biological Activity: Naringenin 4',7-dimethyl ether, Naringenin (HY-N0100) derivative is an anti-seizure agent. Naringenin 4',7-dimethyl ether attenuates pentylenetetrazole-induced seizures in larval zebrafish and reduces seizures in the mouse 6-Hz psychomotor seizure model. Naringenin 4',7-dimethyl ether can be used for the research of epilepsy[1]. Naringenin 4',7-dimethyl ether is an active agent against Leishmania mexicana (17.8 µM) and Trypanosoma brucei (17.5 µM)[2].
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Naringenin 4',7-dimethyl ether | Naringenin 4',7-dimethyl ether, Naringenin (HY-N0100) derivative is an anti-seizure agent. Naringenin 4',7-dimethyl ether attenuates pentylenetetrazole-induced seizures in larval zebrafish and reduces seizures in the mouse 6-Hz psychomotor seizure model. Naringenin 4',7-dimethyl ether can be used for the research of epilepsy. Naringenin 4',7-dimethyl ether is an active agent against Leishmania mexicana (17.8 µM) and Trypanosoma brucei (17.5 µM). | |||||||||||||||||||||
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- [1]. Copmans D, et al. Methylated flavonoids as anti-seizure agents: Naringenin 4',7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models. Neurochem Int. 2018;112:124-133. [Content Brief]
- [2]. Alotaibi A, Ebiloma GU, Williams R, et al. Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana. Molecules. 2021;26(13):3912. [Content Brief]
Keywords
