84-79-7
84-79-7
Chemical Structure
Lapachol
- CAS. Nr.: 84-79-7
- Formula:C15H14O3
- Molecular Weight:242.27
IUPAC Name: 2-hydroxy-3-(3-methylbut-2-en-1-yl)naphthalene-1,4-dione
InChIKey: CIEYTVIYYGTCCI-UHFFFAOYSA-N
SMILES: O=C(C(CC=C(C)C)=C1O)C2=CC=CC=C2C1=O
Biological Activity: Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Lapachol | 99.49% | Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity. | ||||||||||||||||||||
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Lapachol (Standard) | ≥98% | Lapachol (Standard) is the analytical standard of Lapachol. This product is intended for research and analytical applications. Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity. | ||||||||||||||||||||
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DMNQ | 98.69% | DMNQ is a redox cycling agent. DMNQ produces hydrogen peroxide in cells in a concentration-dependent manner. DMNQ can induce the increase of ROS production. | ||||||||||||||||||||
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Vitamin K2(5) | Vitamin K2(5) is an isoprenyl homologue of the Vitamin K2 (HY-109569) series. Vitamin K2(5) occurs in the heartwood of Tabebuia avellanedae. | |||||||||||||||||||||
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Buparvaquone | 99.64% | Buparvaquone is a hydroxynaphthoquinone antiprotozoal agent related to parvaquone and atovaquone. | ||||||||||||||||||||
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Hydrolapachol | Hydrolapachol is a mitochondrial respiratory chain inhibitor that targets the site between cytochrome b and c1, and inhibits succinate oxidation in rat liver mitochondria. Hydrolapachol can be used in studies related to mitochondrial respiration. | |||||||||||||||||||||
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Anti-infective agent 13 | Anti-infective agent 13 is a naphthoquinone-based insecticide/acaricide. Anti-infective agent 13 exhibits insecticidal activity against Bemisia tabaci (sweetpotato whitefly) and Tetranychus urticae (two-spotted spider mite). Anti-infective agent 13 can be used in research related to insect and mite control. | |||||||||||||||||||||
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12-Hydroxysapriparaquinone | 12-Hydroxysapriparaquinone (compound 8) is a rearranged 4,5-seco-abietane diterpenoid isolated from the petroleum ether extract of the root of Salvia rhytidea. | |||||||||||||||||||||
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α-Lapachone | 99.51% | α-Lapachone shows trypanocidal activity. | ||||||||||||||||||||
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Deoxylapachol | 99.50% | Deoxylapachol is a major cytotoxic component of New Zealand brown alga, Landsburgia quercifolia. Deoxylapachol has antifungal and anti-cancer activity. | ||||||||||||||||||||
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2-Amino-3-carboxy-1,4-naphthoquinone | 99.59% | 2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria. | ||||||||||||||||||||
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Parvaquone | Parvaquone is an antiparasite agent with an in vitro ED50 of 0.006 mg/L. Parvaquone reduces the proportion of Theileria parva schizont-infected cells. Parvaquone can be used for the research of east coast fever (Theileria parva infection). | |||||||||||||||||||||
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References
- [1]. Raphael S Peres, et al. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. Arthritis Res Ther. 2017 Mar 7;19(1):47. [Content Brief]
- [2]. Masayo Maeda, et al. Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol. Toxicol Appl Pharmacol. 2008 Jun 1;229(2):232-8. [Content Brief]
- [3]. Iasmin Aparecida Cunha Araújo, et al. Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis. Exp Parasitol. 2019 Apr:199:67-73. [Content Brief]
