1038620-68-6
Chemical Structure
Purfalcamine
- CAS No.: 1038620-68-6
- Formula:C29H33FN8O
- Molecular Weight:528.62
IUPAC Name: (4-((2-(((1r,4r)-4-aminocyclohexyl)amino)-9-(3-fluorophenyl)-9H-purin-6-yl)amino)phenyl)(piperidin-1-yl)methanone
InChIKey: KRCOMOOXOZSNAJ-AFARHQOCSA-N
SMILES: O=C(C1=CC=C(NC2=C3N=CN(C4=CC=CC(F)=C4)C3=NC(N[C@H]5CC[C@H](N)CC5)=N2)C=C1)N6CCCCC6
Biological Activity: Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Purfalcamine | 99.64% | Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage. | ||||||||||||||||||||
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- [1]. Nobutaka Kato, et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol. 2008 Jun;4(6):347-56. [Content Brief]
- [2]. Rajshekhar Y Gaji, et al. Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs. Antimicrob Agents Chemother. 2014 May;58(5):2598-607. [Content Brief]
Keywords
