547-32-0
Chemical Structure
Sulfadiazine sodium
- CAS No.: 547-32-0
- Formula:C10H9N4NaO2S
- Molecular Weight:272.26
IUPAC Name: sodium ((4-aminophenyl)sulfonyl)(pyrimidin-2-yl)amide
InChIKey: JLDCNMJPBBKAHH-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N)C=C1)(N([Na])C2=NC=CC=N2)=O
Biological Activity: Sulfadiazine sodium is an orally active sulfonamide antibiotic. Sulfadiazine sodium competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine sodium persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine sodium targets Toxoplasma gondii DHPS enzyme. Sulfadiazine sodium can be used for the research of congenital toxoplasmosis and bacterial infection[1][2][3][4].
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Sulfadiazine sodium | 98.38% | Sulfadiazine sodium is an orally active sulfonamide antibiotic. Sulfadiazine sodium competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine sodium persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine sodium targets Toxoplasma gondii DHPS enzyme. Sulfadiazine sodium can be used for the research of congenital toxoplasmosis and bacterial infection. | ||||||||||||||||||||
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Sulfadiazine sodium (Standard) | ≥98% | Sulfadiazine sodium (Standard) is the analytical standard of Sulfadiazine sodium (HY-B20273A). This product is intended for research and analytical applications. Sulfadiazine sodium is an orally active sulfonamide antibiotic. Sulfadiazine sodium competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine sodium persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine sodium targets Toxoplasma gondii DHPS enzyme. Sulfadiazine sodium can be used for the research of congenital toxoplasmosis and bacterial infection. | ||||||||||||||||||||
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References
- [1]. Kopmann C, et al. Abundance and transferability of antibiotic resistance as related to the fate of sulfadiazine in maize rhizosphere and bulk soil. FEMS Microbiol Ecol. 2013 Jan;83(1):125-34. [Content Brief]
- [2]. Silva LA, et al. Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil. Exp Parasitol. 2019 Jul;202:7-14. [Content Brief]
