Sulfamerazine-13C6
Based on 1 Customer Validation
Sulfamerazine-13C6 (RP2632-13C6) is 13C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP2632) is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine can be used for the research of Parkinson’s disease and bacterial infection.
For research use only. We do not sell to patients.
- Purity: 99.11%
- CAS No.: 1196157-80-8
- Formula: C513C6H12N4O2S
- Molecular Weight:270.26
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1196157-80-8
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Unlabeled Cas 127-79-7
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Appearance Solid
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Molecular Weight 270.26
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Formula C513C6H12N4O2S
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Color White to off-white
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SMILES
O=S([13C]1=[13CH][13CH]=[13C](N)[13CH]=[13CH]1)(NC2=NC=CC(C)=N2)=O
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Synonyms
RP2632-13C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Aday B, et al. Synthesis of novel sulfonamide analogs containing sulfamerazine/sulfaguanidine and their biological activities. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1005-10. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sulfamerazine-13C6 Related Classifications
HY-B0512S1 Related Classifications
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- Sulfamerazine-13C6
- 1196157-80-8
- RP2632-13C6
- Isotope-Labeled Compounds
- Antibiotic
- Bacterial
- Parkinson’s disease
- meningococcal meningitis
- yeast Ure2 protein
- transgenic C. elegans
- pneumococcal infections
- gonococcal infections
- α-synuclein
- beta-hemolytic streptococcus infections
- urinary tract infections
- human neuroblastoma SH-SY5Y cells
- Inhibitor
- inhibitor
- inhibit