67-03-8
67-03-8
Chemical Structure
Thiamine hydrochloride
Synonym(s): Thiamine chloride hydrochloride; Vitamin B1 hydrochloride
- CAS No.: 67-03-8
- Formula:C12H18Cl2N4OS
- Molecular Weight:337.27
IUPAC Name: 3-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride hydrochloride
InChIKey: DPJRMOMPQZCRJU-UHFFFAOYSA-M
SMILES: CC1=C(CCO)SC=[N+]1CC2=CN=C(C)N=C2N.[Cl-].Cl
Biological Activity: Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thiamine hydrochloride | 99.97% | Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis. | ||||||||||||||||||||
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Thiamine hydrochloride (Standard) | 99.84% | Thiamine (hydrochloride) (Standard) is the analytical standard of Thiamine (hydrochloride). This product is intended for research and analytical applications. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. | ||||||||||||||||||||
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Thiamine-d3 hydrochloride | 98.92% | Thiamine-d3 (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. | ||||||||||||||||||||
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Thiamine-d4 hydrochloride | 97.30% | Thiamine-d4 (hydrochloride) is deuterium labeled Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. | ||||||||||||||||||||
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Thiamine monochloride-13C4 hydrochloride | 98.39% | Thiamine monochloride-13C4 (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. | ||||||||||||||||||||
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Thiamine-13C3 hydrochloride | 99.9% | Thiamine-13C3 (hydrochloride) is the 13C-labeled Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. | ||||||||||||||||||||
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Oxythiamine | 96.28% | Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation. | ||||||||||||||||||||
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Oxythiamine chloride hydrochloride | 96.11% | Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation. | ||||||||||||||||||||
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Oxythiamine chloride | Oxythiamine (Hydroxythiamin) chloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride inhibits cancer cell apoptosis and inhibits cell proliferation. | |||||||||||||||||||||
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Thiamine pyrophosphate (Standard) | 98.40% | Thiamine pyrophosphate (Standard) is the analytical standard of Thiamine pyrophosphate. This product is intended for research and analytical applications. Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases. | ||||||||||||||||||||
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Pyrithiamine hydrobromide | 96.61% | Pyrithiamine (hydrobromide) is an inhibitor of thiamine kinase and thiamine pyrophosphate kinase. Pyrithiamine (hydrobromide) competitively inhibits thiamine transport and reduces intracellular levels of thiamine and its phosphates. Pyrithiamine (hydrobromide) is used to study thiamine deficiency with polyneuritic symptoms and Wernicke's encephalopathy. | ||||||||||||||||||||
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N3PT | 98.63% | N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an Kd value of 22 nM (Apo-TK, transketolase lacking bound thiamine). | ||||||||||||||||||||
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Thiamine monochloride (Standard) | 99.38% | Thiamine monochloride (Standard) (Vitamin B1 (Standard)) is the analytical standard of Thiamine monochloride (HY-A0100). This product is intended for research and analytical applications. Thiamine monochloride (Vitamin B1) is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives. | ||||||||||||||||||||
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Vitamin B1 monophosphate chloride | 99.27% | Vitamin B1 monophosphate (Thiamine monophosphate) chloride is a source of vitamin B1 and can be used in food supplements to enhance nutrition. | ||||||||||||||||||||
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Thiamine nitrate | 99.84% | Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives. | ||||||||||||||||||||
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References
- [1]. Moulin M, et al. Analysis of Chlamydomonas thiamin metabolism in vivo reveals riboswitch plasticity. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14622-7. [Content Brief]
- [2]. Liu X, et al. The Effects of Thiamine on Breast Cancer Cells. Molecules. 2018 Jun 16;23(6):1464. [Content Brief]
- [3]. Hanberry BS, Berger R, Zastre JA. High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer Chemother Pharmacol. 2014 Mar;73(3):585-94. [Content Brief]
- [4]. Avena R, et al. Thiamine (Vitamin B1) protects against glucose- and insulin-mediated proliferation of human infragenicular arterial smooth muscle cells. Ann Vasc Surg. 2000 Jan;14(1):37-43. [Content Brief]
- [5]. Nasir A, et al. Vitamin B1 via Nrf-2/TLR4 signaling pathway ameliorates scopolamine-induced memory dysfunction in adult mice. Arabian Journal of Chemistry, 2024, 17(1): 105350.
- [6]. Zaringhalam J, et al. Long-Term Treatment by Vitamin B1 and Reduction of Serum Proinflammatory Cytokines, Hyperalgesia, and Paw Edema in Adjuvant-Induced Arthritis. Basic Clin Neurosci. 2016 Oct;7(4):331-340. [Content Brief]
- [7]. Dalayeli N, et al. Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats. Int J Prev Med. 2024 Nov 28;15:61. [Content Brief]
