Thiamine monochloride-13C4 hydrochloride
Based on 1 Customer Validation
Thiamine monochloride-13C4 (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.
For research use only. We do not sell to patients.
- Purity: 98.39%
- CAS No.: 1257525-77-1
- Formula: C813C4H18Cl2N4OS
- Molecular Weight:341.24
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1257525-77-1
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Unlabeled Cas 67-03-8
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Appearance Solid
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Molecular Weight 341.24
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Formula C813C4H18Cl2N4OS
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Color White to off-white
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SMILES
[13CH3][13C]([N+](CC(C(N)=N1)=CN=C1C)=[13CH]S2)=[13C]2CCO.[Cl-].Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (293.05 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Moulin M, et al. Analysis of Chlamydomonas thiamin metabolism in vivo reveals riboswitch plasticity. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14622-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.9305 mL | 14.6524 mL | 29.3049 mL | 73.2622 mL |
| 5 mM | 0.5861 mL | 2.9305 mL | 5.8610 mL | 14.6524 mL | |
| 10 mM | 0.2930 mL | 1.4652 mL | 2.9305 mL | 7.3262 mL | |
| 15 mM | 0.1954 mL | 0.9768 mL | 1.9537 mL | 4.8841 mL | |
| 20 mM | 0.1465 mL | 0.7326 mL | 1.4652 mL | 3.6631 mL | |
| 25 mM | 0.1172 mL | 0.5861 mL | 1.1722 mL | 2.9305 mL | |
| 30 mM | 0.0977 mL | 0.4884 mL | 0.9768 mL | 2.4421 mL | |
| 40 mM | 0.0733 mL | 0.3663 mL | 0.7326 mL | 1.8316 mL | |
| 50 mM | 0.0586 mL | 0.2930 mL | 0.5861 mL | 1.4652 mL | |
| 60 mM | 0.0488 mL | 0.2442 mL | 0.4884 mL | 1.2210 mL | |
| 80 mM | 0.0366 mL | 0.1832 mL | 0.3663 mL | 0.9158 mL | |
| 100 mM | 0.0293 mL | 0.1465 mL | 0.2930 mL | 0.7326 mL |
Thiamine monochloride-13C4 hydrochloride Related Classifications
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