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N3PT (Synonyms: N3-pyridyl thiamine)

Cat. No.: HY-16339 Purity: 98.98%
Handling Instructions

N3PT(N3-pyridyl thiamine) is a potent and selective transketolase(TKT) inhibitor (IC50= 22 nM for Apo-TK) both in vitro and in vivo.

For research use only. We do not sell to patients.

N3PT Chemical Structure

N3PT Chemical Structure

CAS No. : 13860-66-7

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5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 456 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1080 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

N3PT(N3-pyridyl thiamine) is a potent and selective transketolase(TKT) inhibitor (IC50= 22 nM for Apo-TK) both in vitro and in vivo. IC50 Value: 22 nM( Apo-TK) ; 26 nM (EC50, Cellular TK) [1] Target: transketolase in vitro: N3PT inhibits transketolase activity in a cell based assay. Competitive inhibition of TK by N3PT in cells treated with increasing doses of thiamine, expressed as percentage enzymatic activity (the slope of initial linear range) of controls not treated with compounds [1]. in vivo: Tumors were induced in mice at day 0 and mice were then treated at day 7 with vehicle alone or with N3PT [2]. Low-thiamine diet enhances the sensitivity to N3PT inhibition of TK in spleen. Animals were switched to diets containing 16.5 mg/kg (unchanged), 5 mg/kg, 1 mg/kg, or 0 mg/kg thiamine, from a normal chow containing 16.5mg/kg thiamine [1].

Molecular Weight

336.28

Formula

C₁₃H₁₉Cl₂N₃OS

CAS No.
SMILES

CC1=C(CCO)SC=[N+]1CC2=CC=C(C)N=C2N.[H]Cl.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2.86 mg/mL (8.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9737 mL 14.8686 mL 29.7371 mL
5 mM 0.5947 mL 2.9737 mL 5.9474 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

N3PTN3-pyridyl thiamineOthersInhibitorinhibitorinhibit

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N3PT
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