486-21-5
486-21-5
Chemical Structure
Isofraxidin
- CAS. Nr.: 486-21-5
- Formula:C11H10O5
- Molecular Weight:222.19
IUPAC Name: 7-hydroxy-6,8-dimethoxy-2H-chromen-2-one
InChIKey: HOEVRHHMDJKUMZ-UHFFFAOYSA-N
SMILES: O=C1C=CC2=CC(OC)=C(O)C(OC)=C2O1
Biological Activity: Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells[1]. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation[2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Isofraxidin | 99.94% | Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Isofraxidin (Standard) | ≥98% | Isofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Dimethylfraxetin | 99.81% | Dimethylfraxetin is a Carbonic anhydrase inhibitor, with a Ki value of 0.0097 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Arteminin | Arteminin is a coumarin that can be found in Artemisia apiacea. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Tomentin | Tomentin is a compound isolated from Sphaeralcea angustifolia. Tomentin inhibits the formation of λ-carrageenan footpad edema at 58 %. Tomentin inhibits the phorbol ester-induced auricular edema formation by 57 %. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Leptodactylone | Leptodactylone is a compound isolated from the stem bark of Citrus medica L. var. sarcodactylis SWINGLE. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Puberulin | Puberulin is a coumarin compound and an orally effective analgesic. Puberulin is present in Choisya ternata var. Sundance. Puberulin exerts analgesic activity against chemical and heat-induced pain agents in mouse models, and this activity does not involve opioid receptors or muscarinic receptors. Puberulin can be used in the research of neuropathic pain. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fraxinol | 98.82% | Fraxinol is isolated from Lobelia chinensis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
5,7,8-Trimethoxycoumarin | 5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC50s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fraxidin | 99.95% | Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Umckalin (Standard) | ≥98% | Umckalin (Standard) is the analytical standard of Umckalin (HY-N8712). Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE2 production. Umckalin can be used for the research of chronic inflammatory diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
5-Hydroxy-6,7,8-trimethoxycoumarin | 5-Hydroxy-6,7,8-trimethoxycoumarin is a Coumarins product that can be isolated from the herbs of Viola yedonensis Makino. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Yamazaki T, et al. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.Biol Pharm Bull. 2010;33(10):1716-22. [Content Brief]
- [2]. Jin J , et al. Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development.Food Funct. 2018 Nov 14;9(11):5641-5652. [Content Brief]
