5,7,8-Trimethoxycoumarin
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC50s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively.
For research use only. We do not sell to patients.
- CAS No.: 60796-65-8
- Formula: C12H12O5
- Molecular Weight:236.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
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| U-937 | CC50 |
>2 mM
Compound: BA-8
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Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
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[PMID: 19716307] |
| U-937 | IC50 |
>400 μM
Compound: BA-8
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Growth inhibition of human U937 cells assessed as [3H]5-methyl thymidine incorporation after 48 hrs by liquid scintillation counting
Growth inhibition of human U937 cells assessed as [3H]5-methyl thymidine incorporation after 48 hrs by liquid scintillation counting
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[PMID: 19716307] |
5,7,8-Trimethoxycoumarin (0-100 μM; 72 h) inhibits the proliferation of Trypanosoma cruzi and L. amazonensis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Trypanosoma cruzi (epimastigotes) and L. amazonensis (promastigote)
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Concentration:1.5, 3.1, 6.2, 12.5, 25, 50 and 100 μM
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Incubation Time:72 h
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Result:Inhibited the proliferation in a dose-dependent manner with IC50s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively.
Chemical Information
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CAS No. 60796-65-8
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Molecular Weight 236.22
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Formula C12H12O5
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SMILES
O=C1C=CC2=C(OC)C=C(OC)C(OC)=C2O1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)