1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. COX
    MMP
    Toll-like Receptor (TLR)
  3. Isofraxidin

Isofraxidin 

Cat. No.: HY-N0774 Purity: 98.14%
Handling Instructions

Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation.

For research use only. We do not sell to patients.

Isofraxidin Chemical Structure

Isofraxidin Chemical Structure

CAS No. : 486-21-5

Size Price Stock Quantity
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
20 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells[1]. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation[2].

IC50 & Target[1][2]

COX-2

 

TLR4

 

MMP-7

 

In Vitro

Isofraxidin inhibits expression of MMP-7 and in vitro cell invasion at a non-toxic level through inhibiting ERK1/2 phosphorylation in hepatoma cell lines[1].
Isofraxidin competitively inhibits TLR4/MD-2 complex formation, and thus TLR4/NF-κB signalling cascades.Isofraxidin has potential in the treatment of Osteoarthritis (OA)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

222.19

Formula

C₁₁H₁₀O₅

CAS No.

486-21-5

SMILES

O=C1C=CC2=CC(OC)=C(O)C(OC)=C2O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1125.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5007 mL 22.5033 mL 45.0065 mL
5 mM 0.9001 mL 4.5007 mL 9.0013 mL
10 mM 0.4501 mL 2.2503 mL 4.5007 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.36 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.36 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

IsofraxidinCOXMMPToll-like Receptor (TLR)CyclooxygenaseMatrix metalloproteinasesMMP-7hepatomacellinvasionERK1/2iNOSCOX-2TLR4MD-2Inhibitorinhibitorinhibit

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Product Name:
Isofraxidin
Cat. No.:
HY-N0774
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