1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. COX
    MMP
    Toll-like Receptor (TLR)
  3. Isofraxidin

Isofraxidin 

Cat. No.: HY-N0774
Handling Instructions

Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation.

For research use only. We do not sell to patients.

Isofraxidin Chemical Structure

Isofraxidin Chemical Structure

CAS No. : 486-21-5

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Description

Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells[1]. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation[2].

IC50 & Target

COX-2

 

TLR4

 

MMP-7

 

In Vitro

Isofraxidin inhibits expression of MMP-7 and in vitro cell invasion at a non-toxic level through inhibiting ERK1/2 phosphorylation in hepatoma cell lines[1].
Isofraxidin competitively inhibits TLR4/MD-2 complex formation, and thus TLR4/NF-κB signalling cascades.Isofraxidin has potential in the treatment of Osteoarthritis (OA)[2].

Molecular Weight

222.19

Formula

C₁₁H₁₀O₅

CAS No.

486-21-5

SMILES

O=C1C=CC2=CC(OC)=C(O)C(OC)=C2O1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IsofraxidinCOXMMPToll-like Receptor (TLR)CyclooxygenaseMatrix metalloproteinasesMMP-7hepatomacellinvasionERK1/2iNOSCOX-2TLR4MD-2Inhibitorinhibitorinhibit

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