1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Dimethylfraxetin

Dimethylfraxetin (Synonyms: 6,7,8-Trimethoxycoumarin; Fraxetin dimethyl ether)

Cat. No.: HY-N0085 Purity: 99.97%
Handling Instructions

Dimethylfraxetin is a Carbonic anhydrase inhibitor, with a Ki value of 0.0097 μM.

For research use only. We do not sell to patients.

Dimethylfraxetin Chemical Structure

Dimethylfraxetin Chemical Structure

CAS No. : 6035-49-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
5 mg USD 156 In-stock
Estimated Time of Arrival: December 31
10 mg USD 276 In-stock
Estimated Time of Arrival: December 31
25 mg USD 552 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Dimethylfraxetin is a Carbonic anhydrase inhibitor, with a Ki value of 0.0097 μM.

IC50 & Target

Ki: 0.0097 μM (Carbonic anhydrase)[1]

In Vitro

At CA I there is one stand out compound being Dimethylfraxetin (compound 17), a nanomolar CA I inhibitor. This trimethoxy coumarin is the most potent of any of the NP coumarins across the six CA isozymes of the present study[1].

Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (529.17 mM; Need ultrasonic and warming)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2333 mL 21.1667 mL 42.3334 mL
5 mM 0.8467 mL 4.2333 mL 8.4667 mL
10 mM 0.4233 mL 2.1167 mL 4.2333 mL
*Please refer to the solubility information to select the appropriate solvent.
Kinase Assay

Inhibitor (including Dimethylfraxetin) and enzyme solutions are preincubated together for 6 h at room temperature prior to assay, in order to allow for the formation of the enzyme-inhibitor complex[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


Dimethylfraxetin6,7,8-TrimethoxycoumarinFraxetin dimethyl etherCarbonic AnhydraseCarbonate dehydrataseInhibitorinhibitorinhibit

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