1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Tioxolone

Tioxolone 

Cat. No.: HY-B0483 Purity: >98.0%
Handling Instructions

Tioxolone, a metalloenzyme carbonic anhydrase I inhibitor, is an anti-acne preparation.

For research use only. We do not sell to patients.

Tioxolone Chemical Structure

Tioxolone Chemical Structure

CAS No. : 4991-65-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
1 g USD 72 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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Description

Tioxolone, a metalloenzyme carbonic anhydrase I inhibitor, is an anti-acne preparation. Target: Carbonic Anhydrase Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. Tioxolone lacks sulfonamide, sulfamate, or hydroxamate functional groups that are typically found in therapeutic carbonic anhydrase (CA) inhibitors, such as acetazolamide. Tioxolone is proposed to be a prodrug inhibitor that is cleaved via a CA II zinc-hydroxide mechanism known to catalyze the hydrolysis of esters. When tioxolone binds in the active site of CA II, it is cleaved and forms 4-mercaptobenzene-1,3-diol via the intermediate S-(2,4-thiophenyl) hydrogen thiocarbonate. The esterase cleavage product binds to the zinc active site via the thiol group and is therefore the active CA inhibitor, while the intermediate is located at the rim of the active-site cavity. From Wikipedia.

Molecular Weight

168.17

Formula

C₇H₄O₃S

CAS No.

4991-65-5

SMILES

O=C1OC2=CC(O)=CC=C2S1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (594.64 mM)

H2O : 0.67 mg/mL (3.98 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9464 mL 29.7318 mL 59.4636 mL
5 mM 1.1893 mL 5.9464 mL 11.8927 mL
10 mM 0.5946 mL 2.9732 mL 5.9464 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (14.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (14.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (14.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Tioxolone
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HY-B0483
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