1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Dorzolamide hydrochloride

Dorzolamide hydrochloride (Synonyms: L671152 hydrochloride; MK507 hydrochloride)

Cat. No.: HY-B0109A Purity: 99.47%
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Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.

For research use only. We do not sell to patients.

Dorzolamide hydrochloride Chemical Structure

Dorzolamide hydrochloride Chemical Structure

CAS No. : 130693-82-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 110 In-stock
Estimated Time of Arrival: December 31
100 mg USD 170 In-stock
Estimated Time of Arrival: December 31
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Description

Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor. Target: carbonic anhydrase (CA) Dorzolamide hydrochloride is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent, and acts by decreasing the production of aqueous humour [1]. Glaucoma was induced in the right eye of adult Wistar rats by episcleral venous occlusion. One experimental group was administered dorzolamide hydrochloride 2%-timolol 0.5% combination eye drops, while the other experimental group was administered dorzolamide hydrochloride2% eye drops. Control groups had surgery without drug administration. Drug application was initiated either 2 weeks before surgery (Group A), from the day of surgery (Group B), 2 weeks after surgery (Group C), or 4 weeks after surgery (Group D). RGCs were labeled by intratectal Fluorogold injections and counted from flat-mount preparations, and IOP was measured using Tonopen. Both dorzolamide-timolol combination and dorzolamide hydrochloride, when applied topically, significantly reduced IOP and improved RGC densities in experimental eyes when compared to control eyes. Earlier initiation, as well as longer duration of drug application, resulted in higher RGC densities [2]. Clinical indications: Glaucoma; Ocular hypertension FDA Approved Date: 1995 Toxicity: Dizziness, headache, shortness of breath, slow heartbeat, severe asthma, cardiac arrest

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 14 mg/mL (38.79 mM; Need ultrasonic and warming)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7709 mL 13.8543 mL 27.7085 mL
5 mM 0.5542 mL 2.7709 mL 5.5417 mL
10 mM 0.2771 mL 1.3854 mL 2.7709 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

360.90

Formula

C₁₀H₁₇ClN₂O₄S₃

CAS No.

130693-82-2

SMILES

O=S(C(S1)=CC2=C1S([[email protected]@H](C)C[[email protected]@H]2NCC)(=O)=O)(N)=O.Cl

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Room temperature in continental US; may vary elsewhere

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Product Name:
Dorzolamide hydrochloride
Cat. No.:
HY-B0109A
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Dorzolamide hydrochloride

Cat. No.: HY-B0109A