1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Dorzolamide hydrochloride

Dorzolamide hydrochloride (Synonyms: L671152 hydrochloride; MK507 hydrochloride)

Cat. No.: HY-B0109A Purity: 99.91%
Handling Instructions

Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity.

For research use only. We do not sell to patients.

Dorzolamide hydrochloride Chemical Structure

Dorzolamide hydrochloride Chemical Structure

CAS No. : 130693-82-2

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 110 In-stock
Estimated Time of Arrival: December 31
100 mg USD 170 In-stock
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Based on 3 publication(s) in Google Scholar

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Description

Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1].

In Vitro

Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Swiss albino mice (EAC solid tumor)[3].
Dosage: 3, 10, or 30 mg/kg/day (synergized mitomycin C).
Administration: IP, daily for 3 weeks.
Result: Upregulated TXNIP and p53 while downregulated bcl-2.
Effective in retarding the growth of EAC in mice.
Clinical Trial
Molecular Weight

360.90

Formula

C₁₀H₁₇ClN₂O₄S₃

CAS No.

130693-82-2

SMILES

O=S(C(S1)=CC2=C1S([[email protected]@H](C)C[[email protected]@H]2NCC)(=O)=O)(N)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (277.09 mM; Need ultrasonic)

H2O : 12.5 mg/mL (34.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7709 mL 13.8543 mL 27.7085 mL
5 mM 0.5542 mL 2.7709 mL 5.5417 mL
10 mM 0.2771 mL 1.3854 mL 2.7709 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.93 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 11 mg/mL (30.48 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

DorzolamideL671152MK507L 671152L-671152MK 507MK-507Carbonic AnhydraseCarbonate dehydrataseCA-IIanti-tumorEACsolidtumorInhibitorinhibitorinhibit

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Product Name:
Dorzolamide hydrochloride
Cat. No.:
HY-B0109A
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