1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Dorzolamide

Dorzolamide (Synonyms: L671152; MK507)

Cat. No.: HY-B0109
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Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity.

For research use only. We do not sell to patients.

Dorzolamide Chemical Structure

Dorzolamide Chemical Structure

CAS No. : 120279-96-1

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Description

Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1].

In Vitro

Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Swiss albino mice (EAC solid tumor)[3].
Dosage: 3, 10, or 30 mg/kg/day (synergized mitomycin C).
Administration: IP, daily for 3 weeks.
Result: Upregulated TXNIP and p53 while downregulated bcl-2.
Effective in retarding the growth of EAC in mice.
Clinical Trial
Molecular Weight

324.44

Formula

C₁₀H₁₆N₂O₄S₃

CAS No.

120279-96-1

SMILES

O=S(C(S1)=CC2=C1S([[email protected]@H](C)C[[email protected]@H]2NCC)(=O)=O)(N)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DorzolamideL671152 MK507L 671152L-671152MK507MK 507MK-507Carbonic AnhydraseCarbonate dehydrataseCA-IIanti-tumorEACsolidtumorInhibitorinhibitorinhibit

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Dorzolamide
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HY-B0109
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