1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. U-104

U-104 (Synonyms: SLC-0111)

Cat. No.: HY-13513 Purity: 99.91%
Handling Instructions

U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model.

For research use only. We do not sell to patients.

U-104 Chemical Structure

U-104 Chemical Structure

CAS No. : 178606-66-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 175 In-stock
Estimated Time of Arrival: December 31
100 mg USD 320 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Description

U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model[1][2].

IC50 & Target

Ki: 45.1 nM (CA IX) and 4.5 nM (CA XII)[1]
EC50: 0.2 μM (exosome)[3]

In Vitro

U-104 (SLC-0111) is a potent exosome inhibitor[3].
U-104 has low inhibition for CA I (Ki=5080 nM) and CA II (Ki=9640 nM)[1].
U-104 (50 μM; for 72 hours) blocks the mesenchymal phenotype in the cancer stem cells population in hypoxia condition of 4T1 cells. U-104 (<50 μM) significantly reduces migration in a dose-dependent manner in metastatic MDA-MB-231 LM2-4Luc+ cells , with cells growing as compact colonies similar to parental MDA-MB-231 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

U-104 (19, 38 mg/kg; daily; for 27 days) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg; daily; for 5 days) inhibits metastases formation in the 4T1 experimental metastasis mice model[1].
U-104 (38 mg/kg; i.p.; from 11 to 27 days) significantly delays primary tumor growth and reduces cancer stem cell population in NOD/SCID mice orthotopically implanted with MDA-MB-231 LM2-4Luc+ cells[2].
U-104 (50 mg/kg; oral gavage; continuously for 4 days and suspended for 1 day; from 10 to 30 days) shows a significant delay in tumor growth in Balb/c mice orthotopically implanted with 4T1 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

309.32

Formula

C₁₃H₁₂FN₃O₃S

CAS No.
SMILES

O=S(C1=CC=C(NC(NC2=CC=C(F)C=C2)=O)C=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (323.29 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2329 mL 16.1645 mL 32.3290 mL
5 mM 0.6466 mL 3.2329 mL 6.4658 mL
10 mM 0.3233 mL 1.6164 mL 3.2329 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

U-104SLC-0111U104U 104SLC0111SLC 0111Carbonic AnhydraseCarbonate dehydrataseCAIXCAXIIexosomeCAICAII4T1MDA-MB-231LM2-4Inhibitorinhibitorinhibit

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Product Name:
U-104
Cat. No.:
HY-13513
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