178606-66-1
178606-66-1
Chemical Structure
U-104
Synonym(s): SLC-0111
- CAS No.: 178606-66-1
- Formula:C13H12FN3O3S
- Molecular Weight:309.32
IUPAC Name: 4-(3-(4-fluorophenyl)ureido)benzenesulfonamide
InChIKey: YJQZNWPYLCNRLP-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(NC(NC2=CC=C(F)C=C2)=O)C=C1)(N)=O
Biological Activity: U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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U-104 | 99.95% | U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model. | ||||||||||||||||||||
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References
- [1]. Lou Y, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 May 1;71(9):3364-76. [Content Brief]
- [2]. Lock FE, et al. Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene. 2013 Oct 31;32(44):5210-9. [Content Brief]
Keywords
