1. Membrane Transporter/Ion Channel
    Apoptosis
  2. VDAC
    Apoptosis
  3. NSC 15364

NSC 15364 

Cat. No.: HY-108937
Handling Instructions

NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis.

For research use only. We do not sell to patients.

NSC 15364 Chemical Structure

NSC 15364 Chemical Structure

CAS No. : 4550-72-5

Size Price Stock Quantity
10 mg USD 65 In-stock
Estimated Time of Arrival: December 31
50 mg USD 185 In-stock
Estimated Time of Arrival: December 31
100 mg USD 300 In-stock
Estimated Time of Arrival: December 31
250 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis[1].

In Vitro

Mitochondrial membrane protein voltage-dependent anion channel 1 (VDAC1) oligomerization represents a prime target for agents designed to modulate apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

242.28

Formula

C₁₃H₁₄N₄O

CAS No.

4550-72-5

SMILES

O=C(NC1=CC=C(N)C=C1)NC2=CC=C(N)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (515.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1275 mL 20.6373 mL 41.2746 mL
5 mM 0.8255 mL 4.1275 mL 8.2549 mL
10 mM 0.4127 mL 2.0637 mL 4.1275 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (8.59 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NSC 15364NSC15364NSC-15364VDACApoptosisVoltage-dependent anion channel neurodegenerativediseaseParkinsonAlzheimercardiovascularVDAC1oligomerizationInhibitorinhibitorinhibit

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Product Name:
NSC 15364
Cat. No.:
HY-108937
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