1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Dichlorphenamide

Dichlorphenamide (Synonyms: Diclofenamide)

Cat. No.: HY-B0397 Purity: >98.0%
Handling Instructions

Dichlorphenamide(Diclofenamide) is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.

For research use only. We do not sell to patients.

Dichlorphenamide Chemical Structure

Dichlorphenamide Chemical Structure

CAS No. : 120-97-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
50 mg USD 144 In-stock
Estimated Time of Arrival: December 31
100 mg USD 250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Dichlorphenamide(Diclofenamide) is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma. Target: Carbonic Anhydrase Dichlorphenamide is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class. This drug has the same side-effects as acetazolamide, for which it is a useful substitute, except for a lesser tendency to cause dermatitis, renal calculi and metabolic acidosis. It may induce a more pronounced renal loss of potassium [1]. An average daily dose of 33 mg of diclofenamide, a carbonic-anhydrase inhibitor, was added to the anti-epileptic medication already employed in 105 cases of severe epilepsy which had shown insufficient clinical improvement. A favourable action on seizures, often accompanied by an improvement in the EEG tracing, was observed in 83 cases. The effect was of long duration in 47 cases in that it lasted for more than a year. It persisted for one to twelve months in a further 17 cases, while in 19 patients, who had reacted favourably to the treatment, medication had to be suspended because of intolerance [2].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 28 mg/mL (91.76 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2770 mL 16.3848 mL 32.7697 mL
5 mM 0.6554 mL 3.2770 mL 6.5539 mL
10 mM 0.3277 mL 1.6385 mL 3.2770 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

305.16

Formula

C₆H₆Cl₂N₂O₄S₂

CAS No.

120-97-8

SMILES

O=S(C1=CC(Cl)=C(Cl)C(S(=O)(N)=O)=C1)(N)=O

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Room temperature in continental US; may vary elsewhere

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Product Name:
Dichlorphenamide
Cat. No.:
HY-B0397
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Dichlorphenamide

Cat. No.: HY-B0397