1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Methazolamide

Methazolamide (Synonyms: L584601)

Cat. No.: HY-B0553 Purity: 97.72%
Handling Instructions

Methazolamide is a carbonic anhydrase inhibitor used to treat glaucoma.

For research use only. We do not sell to patients.

Methazolamide Chemical Structure

Methazolamide Chemical Structure

CAS No. : 554-57-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 84 In-stock
Estimated Time of Arrival: December 31
1 g USD 108 In-stock
Estimated Time of Arrival: December 31
5 g USD 324 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Description

Methazolamide is a carbonic anhydrase inhibitor used to treat glaucoma. Target: Carbonic Anhydrase Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively [1]. Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles. Methazolamide does not impair respiratory work performance in anesthetized rabbits [2]. Oral administration of methazolamide decreases IOPs and AHFRs in clinically normal dogs, with effectiveness diminishing in the evening [3].

Clinical Trial
Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (211.62 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2324 mL 21.1622 mL 42.3245 mL
5 mM 0.8465 mL 4.2324 mL 8.4649 mL
10 mM 0.4232 mL 2.1162 mL 4.2324 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

236.27

Formula

C₅H₈N₄O₃S₂

CAS No.

554-57-4

SMILES

CC(/N=C1SC(S(=O)(N)=O)=NN/1C)=O

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Methazolamide
Cat. No.:
HY-B0553
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Methazolamide

Cat. No.: HY-B0553