2. PROTAC Metabolic Enzyme/Protease
  3. Molecular Glues Carbonic Anhydrase
  4. Indisulam

Indisulam  (Synonyms: E 7070)

Cat. No.: HY-13650 Purity: 99.60%
COA Handling Instructions

Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15.

For research use only. We do not sell to patients.

Indisulam Chemical Structure

Indisulam Chemical Structure

CAS No. : 165668-41-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 84 In-stock
Solution
10 mM * 1 mL in DMSO USD 84 In-stock
Solid
1 mg USD 36 In-stock
5 mg USD 77 In-stock
10 mg USD 110 In-stock
25 mg USD 176 In-stock
50 mg USD 275 In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Indisulam Related Antibodies

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CA I CA Ⅱ CA Ⅸ CA XII

  • Biological Activity

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  • References

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Description

Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15[1][2].

IC50 & Target

Carbonic anhydrase[1].
In Vitro

Indisulam (E7070, 0-50 μg/mL, 12-48 h) causes cell cycle perturbation in the G1 phase in a time- and dose-dependent manner, potentially leading to cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Indisulam Related Antibodies

Cell Cycle Analysis[1]

Cell Line: P388 murine leukaemia cells.
Concentration: 0-50 μg/mL.
Incubation Time: 12-48 h.
Result: Accumulated P388 cells in the G1 phase.
In Vivo

Indisulam (E7070, 12.5, 25, 50 (100) mg/kg) shows an antitumour spectrum in human cancer models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nu/nu mice aged 7 weeks (HCT116 colon, LX-1 lung, SW620 colon, HCT115 colon, PC-9 lung, DLD-1 colon and WiDr colon models)[1].
Dosage: 12.5, 25, 50 (100) mg/kg.
Administration: IV daily for 4 days.
Result: Exhibited anti-tumor activity.
Clinical Trial
Molecular Weight

385.85

Appearance

Solid

Formula

C14H12ClN3O4S2
CAS No.
SMILES

O=S(C1=CC=C(S(=O)(N)=O)C=C1)(NC2=CC=CC3=C2NC=C3Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (259.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5917 mL 12.9584 mL 25.9168 mL
5 mM 0.5183 mL 2.5917 mL 5.1834 mL
10 mM 0.2592 mL 1.2958 mL 2.5917 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.17 mg/mL (5.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.17 mg/mL (5.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.17 mg/mL (5.62 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.60%

COA (254 KB) HNMR (263 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References
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Indisulam Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Indisulam165668-41-7E 7070E7070E-7070Molecular GluesCarbonic AnhydraseCarbonate dehydrataseInhibitorinhibitorinhibit

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