301-19-9
301-19-9
Chemical Structure
Robinin
- CAS No.: 301-19-9
- Formula:C33H40O19
- Molecular Weight:740.66
IUPAC Name: 5-hydroxy-2-(4-hydroxyphenyl)-3-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-7-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChIKey: PEFASEPMJYRQBW-HKWQTAEVSA-N
SMILES: O=C1C(O[C@H]2[C@@H]([C@H]([C@H]([C@@H](CO[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)O2)O)O)O)=C(C4=CC=C(O)C=C4)OC5=CC(O[C@H]6[C@@H]([C@@H]([C@H]([C@H](C)O6)O)O)O)=CC(O)=C15
Biological Activity: Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Robinin | 99.96% | Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Robinin (Standard) | ≥98% | Robinin (Standard) is the analytical standard of Robinin. This product is intended for research and analytical applications. Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Alaternin | Alaternin (Catharticin) is an anthraquinone compound with antioxidant and hepatoprotective activities. Alaternin has an inhibitory activity against hydroxyl radicals generated in a cell-free chemical system (FeSO4/H2O2) with an IC50 value of 3.05 μM. Alaternin exhibits hepatoprotective activity against Tacrine (HY-111338)-induced toxicity in human hepatic HepG2 cells with an EC50 value of 4.02 μM. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Kaempferol-3-O-robinoside-7-O-glucoside | Kaempferol-3-O-robinoside-7-Oglucoside is a double-chain flavonol triglycoside can be extracted from Withania somnifera. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Oxytroflavoside G | Oxytroflavoside G (compound 5) can be isolated from Magnolia utilis. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Kaempferol-3-O-β-D-Glucose-7-O- β-D-Gentianoside | Kaempferol-3-O-β-D-Glucose-7-O-β-D-Gentianoside is a kaempferol glycoside found in the seeds of Lepidium apetalum Willd. Kaempferol-3-O-β-D-Glucose-7-O-β-D-Gentianoside shows no obvious inhibitory effect on Sodium oleate (HY-N1446B)-induced triglyceride overloading in liver cells. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Grosvenorine | 99.64% | Grosvenorine is an orally active flavonoid glycoside found in S. grosvenorii. Grosvenorine exhibits antibacterial, antioxidant and antiinflammation activities. Grosvenorine can induce apoptosis and increases anti-apoptotic Bcl-2 protein expression and reduces pro-apoptotic P53 protein expression in gastric tissues. Grosvenorine enhances mucin/glycoprotein secretion, regulates gastric pH, and reduces gastric lesion incidence.Grosvenorine increases glutathione peroxidase, catalase, and SOD levels, reduces lipid peroxidation (MDA), and lowers TNF-α and IL-6 levels. Grosvenorine can be used for the researches of bacterial infection and Gastric ulcer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Mauritianin | 99.83% | Mauritianin is an orally active kaempferol glycoside. Mauritianin can be isolated from the flowers and leaves of Acalypha indica. Mauritianin is a topoisomerase I inhibitor. Mauritianin has hepatoprotective, neuroprotective, and renoprotective activities. Mauritianin increases vascular tone when used in combination with Alcesefoliside (HY-N5049). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Clovin | Clovin is a flavonoid can be isolated from Melilotus alba. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Clitorin | 99.45% | Clitorin is an orally active flavonoid compound that can be isolated from Carica papaya. Clitorin is an inhibitor of EGFR (IC50: 89.58 nM) and aromatase (IC50: 77.41 nM). Clitorin has antioxidant and anti-tumor activities. In the DPPH and ABTS radical scavenging assays, Clitorin has IC50 values of 91.96 ppm and 250.45 ppm, respectively. In addition, Clitorin can regulate lipogenesis and fatty acid oxidation and can be used in the research of non-alcoholic fatty liver disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Kaempferol 3-O-rutinoside 7-O-glucoside | 99.67% | Kaempferol 3-O-rutinoside-7-O-glucoside is a kaempferol triglycoside found in the ripe fruits of transgenic tomatoes. Kaempferol 3-O-rutinoside-7-O-glucoside belongs to the flavonol glycosides, a class of plant secondary metabolites, and can be used in research related to flavonoid metabolism and foodomics. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Kaempferol 3-O-rhamninoside | Kaempferol 3-O-rhamninoside is a Flavonoids product that can be isolated from the seeds of Patrinia villosa (Thunb.) Juss.. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Janeesh PA, et al. Robinin modulates TLR/NF-κB signaling pathway in oxidized LDL induced human peripheral blood mononuclear cells. Int Immunopharmacol. 2014 Jan;18(1):191-7. [Content Brief]
- [2]. wenwen Zhang, et al. Robinin inhibits pancreatic cancer cell proliferation, EMT and inflammation via regulating TLR2-PI3k-AKT signaling pathway, 10 May 2023.
- [3]. Tsiklauri L, et al. Bioflavonoid Robinin from Astragalus falcatus Lam. Mildly Improves the Effect of Metothrexate in Rats with Adjuvant Arthritis. Nutrients. 2021 Apr 13;13(4):1268. [Content Brief]
- [4]. Janeesh PA, et al. Robinin modulates doxorubicin-induced cardiac apoptosis by TGF-β1 signaling pathway in Sprague Dawley rats. Biomed Pharmacother. 2014 Oct;68(8):989-98. [Content Brief]
