Cat. No.: HY-N3031

Grosvenorine

Customer Review

Based on 1 Customer Validation

Grosvenorine is an orally active flavonoid glycoside found in S. grosvenorii. Grosvenorine exhibits antibacterial, antioxidant and antiinflammation activities. Grosvenorine can induce apoptosis and increases anti-apoptotic Bcl-2 protein expression and reduces pro-apoptotic P53 protein expression in gastric tissues. Grosvenorine enhances mucin/glycoprotein secretion, regulates gastric pH, and reduces gastric lesion incidence.Grosvenorine increases glutathione peroxidase, catalase, and SOD levels, reduces lipid peroxidation (MDA), and lowers TNF-α and IL-6 levels. Grosvenorine can be used for the researches of bacterial infection and Gastric ulcer.

For research use only. We do not sell to patients.

Purity: 99.64%
CAS No.: 156980-60-8
Formula: C₃₃H₄₀O₁₉
Molecular Weight:740.66

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Grosvenorine Chemical Structure

CAS No.: 156980-60-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Bcl-2

IL-6

All Bcl-2 Family Isoforms :

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

In Vitro

Grosvenorine exhibits in vitro inhibitory activity against Gram-positive bacteria with a MIC of less than 70 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Grosvenorine (30-60 mg/kg; I.g.; single pretreatment dose) exhibits dose-dependent gastroprotective activity against Indomethacin (HY-14397)-induced gastric ulcers in SD rats, with 60 mg/kg providing 74.89% lesion inhibition and 30 mg/kg providing 69.03% lesion inhibition via modulation of apoptotic, antioxidant, and inflammatory pathways^[1].
Grosvenorine (250-500 mg/kg; p.o.; single dose) administered orally up to 500 mg/kg is non-toxic in SD rats, with no observed adverse effects on behavior, organ function, or tissue architecture over a 2-week period^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male and female, 7-8 weeks old, 190-200 g; indomethacin-induced gastropathy)^[1]
Dosage:

30 mg/kg; 60 mg/kg
Administration:

I.g.; single pretreatment dose
Result:

Inhibited gastric lesion incidence by 69.03% (30 mg/kg) and 74.89% (60 mg/kg).
Reduced ulcer area and increased gastric mucus weigh.
Lowered total stomach acidity and increased Alcian blue binding capacity.
Elevated gastric tissue superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and reduced malondialdehyde (MDA.
Reduced serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and increased interleukin-10 (IL-10).
Reduced mucosal injury, edema, and inflammatory cell infiltration.
Upregulated anti-apoptotic Bcl-2 protein and downregulated pro-apoptotic P53 protein in gastric tissues.

Chemical Information

CAS No. 156980-60-8
Appearance Solid
Molecular Weight 740.66
Formula C₃₃H₄₀O₁₉
Color Off-white to light yellow
SMILES

O=C1C(O[C@H]2[C@@H]([C@@H]([C@@H](O)[C@H](C)O2)O)O)=C(C3=CC=C(O)C=C3)OC4=CC(O[C@H]5[C@@H]([C@@H]([C@@H](O)[C@H](C)O5)O)O[C@]6([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)CO)=CC(O)=C41
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (135.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3501 mL

6.7507 mL

13.5015 mL

5 mM

0.2700 mL

1.3501 mL

2.7003 mL

10 mM

0.1350 mL

0.6751 mL

1.3501 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ahmed K A A, et al. Grosvenorine (Monk fruit flavonoid) attenuates Indomethacin-mediated gastropathy in vivo: role of P53/Bcl-2, Antioxidant, and inflammatory mediators[J]. Journal of Pharmaceutical Innovation, 2025, 20(5): 203.

[2]. Wu J, et al. A review of the phytochemistry and pharmacology of the fruit of Siraitia grosvenorii (Swingle): A traditional Chinese medicinal food[J]. Molecules, 2022, 27(19): 6618.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.3501 mL	6.7507 mL	13.5015 mL	33.7537 mL
	5 mM	0.2700 mL	1.3501 mL	2.7003 mL	6.7507 mL
	10 mM	0.1350 mL	0.6751 mL	1.3501 mL	3.3754 mL
	15 mM	0.0900 mL	0.4500 mL	0.9001 mL	2.2502 mL
	20 mM	0.0675 mL	0.3375 mL	0.6751 mL	1.6877 mL
	25 mM	0.0540 mL	0.2700 mL	0.5401 mL	1.3501 mL
	30 mM	0.0450 mL	0.2250 mL	0.4500 mL	1.1251 mL
	40 mM	0.0338 mL	0.1688 mL	0.3375 mL	0.8438 mL
	50 mM	0.0270 mL	0.1350 mL	0.2700 mL	0.6751 mL
	60 mM	0.0225 mL	0.1125 mL	0.2250 mL	0.5626 mL
	80 mM	0.0169 mL	0.0844 mL	0.1688 mL	0.4219 mL
	100 mM	0.0135 mL	0.0675 mL	0.1350 mL	0.3375 mL

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Grosvenorine

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All Bcl-2 Family Isoforms

All Glutathione Peroxidase Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Grosvenorine Related Classifications

HY-N3031 Related Classifications